Eleven COVID-19 Outbreaks with Local Transmissions Caused by the Imported SARS-CoV-2 Delta VOC — China, July–August, 2021

Zhou, Lei; Nie, Kai; Zhao, Hongqun; Zhao, Xiang; Ye, Bixiong; Wang, Ji; Chen, Cao; Wang, Hong; Di, Jiangli; Li, Jinsong; Li, Chao; Chen, Zhixiao; Ren, Ruiqi; Niu, Peihua; Chen, Hui; Chen, Tao; Wang, Yali; Li, Lili; Han, Bingfeng; Ruhan, A; Chen, Si; Li, Dan; Jin, Chunxia; Zhang, Xin; Liu, Jiangmei; Xu, Chunyu; Yao, Yecheng; Feng, Yenan; Li, Zhili; Zhang, Bike; Song, Yang; Hao, Peter; Zhang, Yanping; Li, Hao; Li, Qun; Gao, George F.; Shi, Guoqing; Xu, Wenbo

doi:10.46234/ccdcw2021.213

Cited by 23 publications

(25 citation statements)

References 10 publications

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“…These patients were in the wild-type cohort. In parallel, 336 patients with COVID-19 in the delta variant cohort were admitted and hospitalized at the Third People's Hospital of Yangzhou City (TPHYC), Jiangsu Province, China, in August 2021, where the delta variant of SARS-CoV-2 has been identified as the responsible pathogen ( 21 ). No ICU patients were reported in this cohort.…”

Section: Methodsmentioning

confidence: 99%

Differences in Clinical Characteristics Between Delta Variant and Wild-Type SARS-CoV-2 Infected Patients

Huang

Zhang

et al. 2022

Front. Med.

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Background: As delta variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) prevailed in the current coronavirus disease 2019 (COVID-19) pandemic, its clinical characteristics with the difference from those of wild-type strains have been little studied.Methods: We reported one cohort of 341 wild-type patients with COVID-19 admitted at Wuhan, China in 2020 and the other cohort of 336 delta variant patients with COVID-19 admitted at Yangzhou, China in 2021, with comparisons of their demographic information, medical history, clinical manifestation, and hematological data. Furthermore, within the delta variant cohort, patients with none, partial, and full vaccination were also compared to assess vaccine effectiveness.Findings: For a total of 677 patients with COVID-19 included in this study, their median age was 53.0 years [interquartile range (IQR): 38.0–66.0] and 46.8% were men. No difference was found in age, gender, and percentage of patients with the leading comorbidity between wild-type and delta variant cohorts, but delta variant cohort showed a lessened time interval between disease onset to hospitalization, a reduced portion of patients with smoking history, and a lowered frequency of clinical symptoms. For hematological parameters, most values demonstrated significant differences between wild-type and delta variant cohorts, while full vaccination rather than partial vaccination alleviated the disease condition. This reflected the viremic effect of delta variant when vaccination succeeds or fails to protect.Interpretation: Delta variant of SARS-CoV-2 may cause severe disease profiles, but timely diagnosis and full vaccination could protect patients with COVID-19 from worsened disease progression.

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Section: Methodsmentioning

confidence: 99%

Differences in Clinical Characteristics Between Delta Variant and Wild-Type SARS-CoV-2 Infected Patients

Huang

Zhang

et al. 2022

Front. Med.

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“…Since its outbreak in late 2019, coronavirus disease 2019 (COVID-19) has remained a global pandemic for nearly two years, which poses a huge test on the resilience of global public health system (1). After experiencing the large-scale epidemic in February 2020, China has entered a normalization stage of prevention and control since May 2020 (2). In response to the spread of the highly transmissible Delta variant, China adopted a new strategy called "Dynamic COVID-zero" from August 2021.…”

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confidence: 99%

The Dynamic COVID-Zero Strategy in China

Liu¹,

Liu²,

Wan³

2022

China CDC Weekly

107

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“…For COVID-19 patients admitted at Yangzhou, China in August 2021 (Table 2), the epidemiological investigation confirmed that their infections were due to the spreading of delta variant SARS-CoV-2 (6). Their hematological profiles were divided into groups of patients with no, partial (one-dose), and full (two-dose) vaccinations, and then unvaccinated delta variant COVID-19 patients in Yangzhou were compared to (unvaccinated) patients in Wuhan as well as the partially or fully vaccinated patients, respectively.…”

Section: Resultsmentioning

confidence: 84%

“…We here report a total of 677 COVID-19 patients admitted at separate centers in China, where a cohort of 341 patients was hospitalized in Wuhan, Hubei Province during January-April 2020, and a cohort of 336 patients was hospitalized in Yangzhou, Jiangsu Province on August 2021 where the infections were identified to be caused by delta variant of SARS-CoV-2 ( 6 ). Clinical characteristics centered on RBC features were elaborated and compared between two cohorts of COVID-19 patients, to distinguish its delta variant from wild-type SARS-CoV-2 in their infection profiles.…”

Section: Resultsmentioning

confidence: 99%

Association Between Red Blood Cell Distribution Width and COVID-19 Severity in Delta Variant SARS-CoV-2 Infection

Zhang

Huang

et al. 2022

Front. Med.

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Studies have discovered that wild-type SARS-CoV-2 infections are commonly linked to abnormalities in the hematological profiles of COVID-19 patients, one such abnormality being characterized by elevations in red blood cell distribution width (RDW). Whether this linkage reoccurs in delta variant SARS-CoV-2 infection remains unexamined. Here we compared baseline blood parameters in COVID-19 patients infected by wild type and its delta variant, respectively. Our results here point to that although the delta variant has shown increased virulence, transmissibility, and vaccine escape, it has a minimally negative impact on RDW values that were previously found prognostic for COVID-19 severity.

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Eleven COVID-19 Outbreaks with Local Transmissions Caused by the Imported SARS-CoV-2 Delta VOC — China, July–August, 2021

Cited by 23 publications

References 10 publications

Differences in Clinical Characteristics Between Delta Variant and Wild-Type SARS-CoV-2 Infected Patients

Differences in Clinical Characteristics Between Delta Variant and Wild-Type SARS-CoV-2 Infected Patients

The Dynamic COVID-Zero Strategy in China

Association Between Red Blood Cell Distribution Width and COVID-19 Severity in Delta Variant SARS-CoV-2 Infection

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