Association Between Red Blood Cell Distribution Width and COVID-19 Severity in Delta Variant SARS-CoV-2 Infection

Zhang, Jianguo; Hu, Jianhui; Huang, Xing; Fu, Shixiang; Ding, Daoyin; Tao, Zhimin

doi:10.3389/fmed.2022.837411

Cited by 6 publications

(6 citation statements)

References 12 publications

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“…In the earlier reports we analyzed and compared the clinical characteristics between patients infected by the wild-type or delta variant SARS-CoV-2 ( 14 , 15 ). Herein we investigated the demographic information and baseline characteristics of confirmed COVID-19 patients infected with the omicron variants during the recent coronavirus flareup in the city of Suzhou, China, in February and March 2022.…”

Section: Introductionmentioning

confidence: 99%

Clinical Characteristics of COVID-19 Patients Infected by the Omicron Variant of SARS-CoV-2

et al. 2022

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BackgroundCurrently, as the omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) surges amid the coronavirus disease 2019 (COVID-19) pandemic, its clinical characteristics with intrinsic severity and the protection from vaccination have been understudied.MethodsWe reported 169 COVID-19 patients that were infected with the omicron variant of SARS-CoV-2 and hospitalized in Suzhou, China, from February to March 2022, with their demographic information, medical/immunization history, clinical symptom, and hematological profile. At the same time, patients with none/partial (one-dose), full (two-dose) and three–dose vaccination were also compared to assess the vaccine effectiveness.FindingsFor the omicron COVID-19 patients included in this study, their median age was 33.0 [interquartile range (IQR): 24.0–45.5], 53.3% were male and the median duration from illness onset to hospitalization was 2 days. Hypertension, bronchitis, and diabetes were the leading comorbidities among patients. While the common clinical symptoms included cough, fever, expectoration, and fatigue, etc., asymptomatic patients took up a significant portion (46.7%). For hematological parameters, most values revealed the alleviated pathogenicity induced by the omicron variant infection. No critically ill or deceased patients due to COVID-19 infection were reported in this study.InterpretationOur results supported that the viremic effect of the omicron variant became milder than the previous circulating variants, while full vaccination or booster shot was greatly desired for an effective protection against clinical severity.

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Section: Introductionmentioning

confidence: 99%

Clinical Characteristics of COVID-19 Patients Infected by the Omicron Variant of SARS-CoV-2

et al. 2022

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“…Notably, increased serum LDH is known to be associated with severe COVID-19 ( 34 , 35 ), and a recent study demonstrated that the serum concentration of LDH correlates in a positive manner with the degree of lung injury in patients with acute COVID-19 ( 34 ). In addition, we found that the plasma concentration of IL-26 is associated with decreased MCH, a hematological aberration detectable in mild, and further decreased in severe, cases of COVID-19 ( 36 , 37 ). Taken together, these findings are suggestive of a mechanistic link between IL-26 and severe COVID-19 that deserves further investigation in larger study materials.…”

Section: Discussionmentioning

confidence: 74%

Increased IL-26 associates with markers of hyperinflammation and tissue damage in patients with acute COVID-19

et al. 2022

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Interleukin-26 (IL-26) is released by several immune and structural cells following stimulation of toll-like receptors (TLRs), whereupon it can directly inhibit viral replication and enhance neutrophil chemotaxis. Given these unique properties, IL-26 has emerged as an intriguing mediator of host defense in the lungs. However, the role of IL-26 in COVID-19 has not been thoroughly investigated. Here, we characterized the involvement of IL-26 in the hyperinflammation and tissue damage that occurs in patients with acute COVID-19. We found that IL-26 is markedly increased in blood samples from these patients, and that the concentration of IL-26 correlates with those of the neutrophil-mobilizing cytokines IL-8 and TNFα, respectively. Moreover, the increase in blood IL-26 correlates with enhanced surface expression of the “don’t eat me” signal CD47 on blood neutrophils isolated from patients with acute COVID-19. Finally, we found that the blood concentration of IL-26 correlates with that of increased lactate dehydrogenase, an established marker of tissue damage, and decreased mean corpuscular hemoglobin (MCH), a previously verified hematological aberration in COVID-19, both of which are associated with severe disease. Thus, our findings indicate that increased systemic IL-26 associates with markers of hyperinflammation and tissue damage in patients with acute COVID-19, thereby forwarding the kinocidin IL-26 as a potential target for diagnosis, monitoring, and therapy in this deadly disease.

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“…Predominating immature myeloid cell populations have been observed in critically ill COVID‐19 patients. In this regard, higher RDW and PDW levels at admission were observed among severe COVID‐19 patients and those who passed away compared to survivors 6,27–36 …”

Section: Discussionmentioning

confidence: 91%

“…In this regard, higher RDW and PDW levels at admission were observed among severe COVID‐19 patients and those who passed away compared to survivors. 6 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 …”

Section: Discussionmentioning

confidence: 99%

Platelet‐derived immuno‐inflammatory indices show best performance in early prediction of COVID‐19 progression

Milenković

Djindjić

Djordjević

et al. 2022

Clinical Laboratory Analysis

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Background Coronavirus disease 2019 (COVID‐19) profoundly affects the immune and hematopoietic systems with various degrees of reactive changes in the blood cell counts. Immuno‐inflammatory indices are considered a simple and effective tool in the prediction of COVID‐19 outcomes. We aimed to evaluate and compare the usefulness of leukocyte and platelet counts‐based immuno‐inflammatory indices on admission to hospital in predicting COVID‐19 progression and mortality. Methods A total of 945 patients were enrolled. In addition to blood cell counts, we assessed hemogram‐derived immuno‐inflammatory indices in relation to COVID‐19 progression and death. The indices were tested by analysis of variance, receiver operating characteristic curve analysis, and binomial logistic regressions. Results Patients with severe COVID‐19 had significantly higher counts of neutrophils, eosinophils, and large immature cells (LIC), while decreased counts of platelets and monocytes. Lymphopenia was found in all of the patients, but without significant association with the outcomes. Patients with a LIC count ≥0.265 x 0 9 /L had 54.7% more odds of having COVID‐19 progression. In multivariable analyses, platelets/neutrophil‐to‐lymphocyte ratio (P/NLR) and platelets‐to‐neutrophil radio (P/N) were significant independent predictors of COVID‐19 progression and mortality. The odds of a poor outcome were two times higher in cases with P/NLR < 43 x 10 9 /L and P/N < 29 x 10 9 /L. Conclusion Indices that include platelet count in combination with neutrophil and/or lymphocyte counts displayed the best discriminatory ability and prognostic value of COVID‐19 outcomes. Additionally, LIC showed promising results in the early identification of severe COVID‐19.

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Association Between Red Blood Cell Distribution Width and COVID-19 Severity in Delta Variant SARS-CoV-2 Infection

Cited by 6 publications

References 12 publications

Clinical Characteristics of COVID-19 Patients Infected by the Omicron Variant of SARS-CoV-2

Clinical Characteristics of COVID-19 Patients Infected by the Omicron Variant of SARS-CoV-2

Increased IL-26 associates with markers of hyperinflammation and tissue damage in patients with acute COVID-19

Platelet‐derived immuno‐inflammatory indices show best performance in early prediction of COVID‐19 progression

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