Elevation of Circulating NO: Its Effects on Hemodynamics and Vascular Smooth Muscle Cell Proliferation in Rats

Hecker, G; Denzer, Dustin L; Wohlfeil, Stefan

doi:10.1007/978-3-0348-7346-8_24

Cited by 3 publications

(2 citation statements)

References 8 publications

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“…This induces the relaxation of arterioles and large venous and arterial vessels independent of the endothelium, a decrease in the tone of smooth vascular muscles, the concentration-dependent inhibition of platelet aggregation, and the release of platelet-derived vasoactive compounds. SIN-1 increases nitrite/nitrate levels and inhibits adenosine, thrombin, serotonin, collagen and "plateletactivating factor" [45,46,49].…”

Section: Source Of Supportmentioning

confidence: 99%

Nitric Oxide-Based Treatment of Poor-Grade Patients After Severe Aneurysmal Subarachnoid Hemorrhage

et al. 2019

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Background: Patients with aneurysmal subarachnoid hemorrhage (aSAH) require close treatment in neuro intensive care units (NICUs). The treatments available to counteract secondary deterioration and delayed ischemic events remain restricted; moreover, available neuro-monitoring of comatose patients is undependable. In comatose patients, clinical signs are hidden, and timing interventions to prevent the evolution of a perfusion disorder in response to fixed ischemic brain damage remain a challenge for NICU teams. Consequently, comatose patients often suffer secondary brain infarctions. The outcomes for long-term intubated patients w/wo pupil dilatation are the worst, with only 10% surviving. We previously added two nitroxide (NO) donors to the standard treatment: continuous intravenous administration of Molsidomine in patients with mild-to-moderate aSAH and, if required as a supplement, intraventricular boluses of sodium nitroprusside (SNP) in high-risk patients to overcome the so-called NO-sink effect, which leads to vasospasm and perfusion disorders. NO boluses were guided by clinical status and promptly reversed recurrent episodes of delayed ischemic neurological deficit. In this study, we tried to translate this concept, the initiation of intraventricular NO application on top of continuous Molsidomine infusion, from awake to comatose patients who lack neurological-clinical monitoring but are primarily monitored using frequently applied transcranial Doppler (TCD). Methods: In this observational, retrospective, nonrandomized feasibility study, 18 consecutive aSAH comatose/intubated patients (Hunt and Hess IV/V with/without pupil dilatation) whose poor clinical status precluded clinical monitoring received standard neuro-intensive care, frequent TCD monitoring, continuous intravenous Molsidomine plus intraventricular SNP boluses after TCD-confirmed macrospasm during the daytime and on a fixed nighttime schedule. Results: Very likely associated with the application of SNP, which is a matter of further investigation, vasospasmrelated TCD findings promptly and reliably reversed or substantially weakened (p < 0.0001) afterward. Delayed cerebral ischemia (DCI) occurred only during loose, low-dose or interrupted treatment (17% vs. an estimated 65% with secondary infarctions) in 17 responders. However, despite their worse initial condition, 29.4% of the responders survived (expected 10%) and four achieved Glasgow Outcome Scale Extended (GOSE) 8-6, modified Rankin Scale (mRS) 0-1 or National Institutes of Health Stroke Scale (NIHSS) 0-2.

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Section: Source Of Supportmentioning

confidence: 99%

Nitric Oxide-Based Treatment of Poor-Grade Patients After Severe Aneurysmal Subarachnoid Hemorrhage

et al. 2019

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“…NO also suppresses the aggregation of platelets and promotes endothelialization (67), but slow release of NO from coated stents had no effect on the development of IH (17). Neither did oral administration of an NO‐releasing drug have any effect on SMC proliferation (76).…”

Section: Prevention Of Ihmentioning

confidence: 99%

Restenosis after balloon angioplasty and/or stent insertion - origin and prevention. A review of the literature

Cwikiel

2002

Acta Radiologica

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A novel procedure for daily measurements of hemodynamical, hematological, and biochemical parameters in conscious unrestrained rats

Blouin¹,

Molez²,

Pham³

et al. 2000

Journal of Pharmacological and Toxicological Methods

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Elevation of Circulating NO: Its Effects on Hemodynamics and Vascular Smooth Muscle Cell Proliferation in Rats

Cited by 3 publications

References 8 publications

Nitric Oxide-Based Treatment of Poor-Grade Patients After Severe Aneurysmal Subarachnoid Hemorrhage

Nitric Oxide-Based Treatment of Poor-Grade Patients After Severe Aneurysmal Subarachnoid Hemorrhage

Restenosis after balloon angioplasty and/or stent insertion - origin and prevention. A review of the literature

A novel procedure for daily measurements of hemodynamical, hematological, and biochemical parameters in conscious unrestrained rats

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