Elevation of activity level in the rat following transition from ad libitum to restricted feeding.

Hall, John F.; Smith, Kendon; Schnitzer, Samuel B.; Hanford, Peter V.

doi:10.1037/h0062565

Cited by 48 publications

(31 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This is suggested by the observation that reduced food intake increases running wheel activity in rodents (24,30,33). This phenomenon, which is called activity-based anorexia (ABA), has been proposed as a model for investigating behavioral traits related to anorexia nervosa (24,45). Rats increase their locomotor activity in response to 3 days of food deprivation (47), and, similarly, an increase in dark-and light-phase locomotor activity is seen in mice exposed to caloric restriction (7,38,58).…”

mentioning

confidence: 91%

“…Increased locomotor activity is a component of behavioral thermoregulation, and the amplitude of the increase may be modified by the degree of restriction. This is suggested by the observation that reduced food intake increases running wheel activity in rodents (24,30,33). This phenomenon, which is called activity-based anorexia (ABA), has been proposed as a model for investigating behavioral traits related to anorexia nervosa (24, 45).…”

mentioning

confidence: 97%

See 1 more Smart Citation

Behavioral, physiological, and molecular differences in response to dietary restriction in three inbred mouse strains

Gelegen¹,

Collier²,

Campbell

et al. 2006

American Journal of Physiology-Endocrinology and Metabolism

View full text Add to dashboard Cite

Food restriction paradigms are widely used in animal studies to investigate systems involved in energy regulation. We have observed behavioral, physiological, and molecular differences in response to food restriction in three inbred mouse strains, C57BL/6J, A/J, and DBA/2J. These are the progenitors of chromosome substitution and recombinant inbred mouse strains used for mapping complex traits. DBA/2J and A/J mice increased their locomotor activity during food restriction, and both displayed a decrease in body temperature, but the decrease was significantly larger in DBA/2J compared with A/J mice. C57BL/6J mice did not increase their locomotor activity and displayed a large decrease in their body temperature. The large decline in body temperature during food restriction in DBA/2J and C57BL/6J strains was associated with a robust reduction in plasma leptin levels. DBA/2J mice showed a marked decrease in white and brown adipose tissue masses and an upregulation of the antithermogenic hypothalamic neuropeptide Y Y(1) receptor. In contrast, A/J mice showed a reduction in body temperature to a lesser extent that may be explained by downregulation of the thermogenic melanocortin 3 receptor and by behavioral thermoregulation as a consequence of their increased locomotor activity. These data indicate that genetic background is an important parameter in controlling an animal's adaptation strategy in response to food restriction. Therefore, mouse genetic mapping populations based on these progenitor lines are highly valuable for investigating mechanisms underlying strain-dependent differences in behavioral physiology that are seen during reduced food availability.

show abstract

mentioning

confidence: 91%

mentioning

confidence: 97%

Behavioral, physiological, and molecular differences in response to dietary restriction in three inbred mouse strains

Gelegen¹,

Collier²,

Campbell

et al. 2006

American Journal of Physiology-Endocrinology and Metabolism

View full text Add to dashboard Cite

show abstract

“…During the illness, regardless of low body weight, an increase in physical activity is observed [12], [20]. The effects of limited food intake and hyperactivity under these conditions can be modelled in animals [21], [22].…”

Section: Introductionmentioning

confidence: 99%

“…Activity based anorexia (ABA) is an animal model of pathophysiological processes of AN where the combined effects of daily scheduled limited food availability and voluntary running wheel activity mimic the physical hyperactivity behaviour observed in AN patients while their food intake is severely reduced. In this model, rodents have unlimited voluntary access to a running wheel throughout the experiment, while food is ad libitum available for a limited period at the same time during several consecutive days [21], [22]. The resulting physical hyperactivity under this conditions is a core feature of this model [24], [25] and has clinical relevance [26], [27].…”

Section: Introductionmentioning

confidence: 99%

Identifying Predictors of Activity Based Anorexia Susceptibility in Diverse Genetic Rodent Populations

et al. 2012

View full text Add to dashboard Cite

Animal studies are very useful in detection of early disease indicators and in unravelling the pathophysiological processes underlying core psychiatric disorder phenotypes. Early indicators are critical for preventive and efficient treatment of progressive psychiatric disorders like anorexia nervosa. Comparable to physical hyperactivity observed in anorexia nervosa patients, in the activity-based anorexia rodent model, mice and rats express paradoxical high voluntary wheel running activity levels when food restricted. Eleven inbred mouse strains and outbred Wistar WU rats were exposed to the activity-based anorexia model in search of identifying susceptibility predictors. Body weight, food intake and wheel running activity levels of each individual mouse and rat were measured. Mouse strains and rats with high wheel running activity levels during food restriction exhibited accelerated body weight loss. Linear mixed models for repeated measures analysis showed that baseline wheel running activity levels preceding the scheduled food restriction phase strongly predicted activity-based anorexia susceptibility (mice: Beta = −0.0158 (±0.003 SE), P<0.0001; rats: Beta = −0.0242 (±0.004 SE), P<0.0001) compared to other baseline parameters. These results suggest that physical activity levels play an important role in activity-based anorexia susceptibility in different rodent species with genetically diverse background. These findings support previous retrospective studies on physical activity levels in anorexia nervosa patients and indicate that pre-morbid physical activity levels could reflect an early indicator for disease severity.

show abstract

“…In the ABA paradigm, 7,8 animals (typically rats) are given restricted access to unlimited food (1-2 h/day) and ad libitum access to a running wheel. Within days, rats in this paradigm develop increased wheel running and weight loss, decreased food intake, and loss of estrous cycle function.…”

Section: Introductionmentioning

confidence: 99%

Activity‐based anorexia during adolescence does not promote binge eating during adulthood in female rats

Cai¹,

Bocarsly²,

Arner³

et al. 2008

Intl J Eating Disorders

View full text Add to dashboard Cite

show abstract

Elevation of activity level in the rat following transition from ad libitum to restricted feeding.

Cited by 48 publications

References 3 publications

Behavioral, physiological, and molecular differences in response to dietary restriction in three inbred mouse strains

Behavioral, physiological, and molecular differences in response to dietary restriction in three inbred mouse strains

Identifying Predictors of Activity Based Anorexia Susceptibility in Diverse Genetic Rodent Populations

Activity‐based anorexia during adolescence does not promote binge eating during adulthood in female rats

Contact Info

Product

Resources

About