Activity‐based anorexia during adolescence does not promote binge eating during adulthood in female rats

Cai, Wei; Bocarsly, Miriam E.; Arner, Candice N.; Walsh, B. Timothy; Foltin, Richard W.; Hoebel, Bartley G.; Barbarich-Marsteller, Nicole C.

doi:10.1002/eat.20568

Cited by 4 publications

(3 citation statements)

References 12 publications

(11 reference statements)

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“…Research examining anorexic effects of exercise, referred to as activity anorexia, are difficult to replicate in human subjects and explanations of this effect in humans typically include some recognition of culture (Epling & Pierce, 1996). Recent animal research using rats has also failed to support research showing activity‐based anorexia during youth promotes the development of binge eating during adulthood (Cai et al, 2008). Thus, increased activity early in life may not be responsible for pathological eating behaviours, and therefore subsequent ED later in life.…”

Section: Introductionmentioning

confidence: 99%

“…In summary, the limitations of bias clinical observations (Katz, 1996), retrospective research designs (Davis, Katzman, & Kirsh, 1999), vague operational definitions of excessive exercise (APA, 2000), inconclusive animal research (Cai et al, 2008) and overlooking potential mediating psychological variables (Adkins & Keel, 2005; Cook & Hausenblas, 2008; Zmijewski & Howard, 2003) supports the need for theoretically driven models that explain the relationship between ED and the psychological motivation as well as the physical affect of exercise (Jansen, 2001; Thome & Espelage, 2007) to further our understanding of this important area.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Eating disorders and exercise: A structural equation modelling analysis of a conceptual model

Cook¹,

Hausenblas²,

Tuccitto³

et al. 2011

Euro Eating Disorders Rev

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Eating disorders and exercise: A structural equation modelling analysis of a conceptual model

Cook¹,

Hausenblas²,

Tuccitto³

et al. 2011

Euro Eating Disorders Rev

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show abstract

“…We chose to expose animals to two bouts of ABA for a number of reasons. First, given that there is currently only one report of ABA in adolescent female rats [25], whether it could be implemented and whether it was repeatable in rats of this age required verification. Second, in young women the onset of AN often occurs during mid- to late- adolescence [8, 9].…”

Section: Introductionmentioning

confidence: 99%

Adolescent activity-based anorexia increases anxiety-like behavior in adulthood

Kinzig

Hargrave

2010

Physiology & Behavior

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Activity-based anorexia is a paradigm that induces increased physical activity, reduced food intake, and heightened activity of the hypothalamic-pituitary-adrenal axis in adult rats. To investigate whether experience with activity-based anorexia produced enduring effects on brain and behavior, female adolescent rats experienced activity-based anorexia during adolescence and were tested in adulthood for anxiety-like behavior on an elevated plus maze and in an open field. Analysis of elevated plus maze and open field behavior in adulthood revealed that rats that experienced activity-based anorexia during adolescence, but not rats that were simply food restricted, displayed increased anxiety-like behavior in adulthood. Plasma corticosterone and expression levels of corticotropin-releasing hormone mRNA in the hypothalamic paraventricular nucleus and in the central nucleus of the amygdala were significantly elevated in adult rats that had undergone activity-based anorexia in adolescence in response to the open field exposure, as compared to control rats. These data demonstrate enduring effects of adolescent activity-based anorexia on anxiety-like behavior and neuroendocrine factors critical in stress responsivity in adulthood. Furthermore, we demonstrate that activity-based anorexia during adolescence serves as a model whereby prolonged anxiety is induced, allowing for evaluation of the behavioral and neural correlates of mediating anxiety-like behaviors in adulthood.

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Activity Based Anorexia as an Animal Model for Anorexia Nervosa–A Systematic Review

Schalla

Stengel

2019

Front. Nutr.

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Anorexia nervosa (AN) is a severe eating disorder affecting around 1 per 100 persons. However, the knowledge about its underlying pathophysiology is limited. To address the need for a better understanding of AN, an animal model was established early on in the late 1960's: the activity-based anorexia (ABA) model in which rats have access to a running wheel combined with restricted food access leading to self-starving/body weight loss and hyperactivity. Both symptoms, separately or combined, can also be found in patients with AN. The aim of this systematic review was to compile the current knowledge about this animal model as well as to address gaps in knowledge. Using the data bases of PubMed, Embase and Web of science 102 publications were identified meeting the search criteria. Here, we show that the ABA model mimics core features of human AN and has been characterized with regards to brain alterations, hormonal changes as well as adaptations of the immune system. Moreover, pharmacological interventions in ABA animals and new developments, such as a chronic adaptation of the ABA model, will be highlighted. The chronic model might be well suited to display AN characteristics but should be further characterized. Lastly, limitations of the model will be discussed.

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Activity‐based anorexia during adolescence does not promote binge eating during adulthood in female rats

Abstract: A brief episode of ABA during adolescence did not lead to increased binge eating later in life. Longer-term models are needed to determine whether a propensity toward binge eating may result from more sustained ABA during adolescence.

Cited by 4 publications

References 12 publications

Eating disorders and exercise: A structural equation modelling analysis of a conceptual model

Eating disorders and exercise: A structural equation modelling analysis of a conceptual model

Adolescent activity-based anorexia increases anxiety-like behavior in adulthood

Activity Based Anorexia as an Animal Model for Anorexia Nervosa–A Systematic Review

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