Elevated Serum Uric Acid Levels During Treatment With Antihypertensive Drugs

Bengtsson, Calle

doi:10.1111/j.0954-6820.1979.tb00781.x

Cited by 14 publications

(2 citation statements)

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“…Other studies have shown consistent finding that diuretic and beta blocker treatments gives similar changes in kidney function [36, 39]. Increases in urate levels associated with treatment with diuretics (but not potassium-sparing diuretics) and beta blockers have been reported previously [8, 18, 36, 40] and so results here are not unexpected. Bengtsson has recommended monitoring of serum uric acid levels after treatments with diuretics [40].…”

Section: Discussionsupporting

confidence: 90%

“…Increases in urate levels associated with treatment with diuretics (but not potassium-sparing diuretics) and beta blockers have been reported previously [8, 18, 36, 40] and so results here are not unexpected. Bengtsson has recommended monitoring of serum uric acid levels after treatments with diuretics [40]. However, in recent times, there has been new debate [41–43], as to its significance for both hypertension and cardiovascular disease: “an innocent bystander” or a “central player”?…”

Section: Discussionsupporting

confidence: 86%

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Changes in selected metabolic parameters in patients over 65 receiving hydrochlorothiazide plus amiloride, atenolol or placebo in the MRC elderly trial

Damian

McNamee

Carr

2016

BMC Cardiovasc Disord

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BackgroundTreatment of hypertension reduces incidence of stroke, myocardial infarction and heart failure perhaps partly by controlling different metabolic parameters. There is limited information regarding the changes in potassium, sodium, weight, cholesterol and glucose levels in patients using anti-hypertensives. This study aimed to determine changes in potassium, sodium, glucose, cholesterol, weight, urea and urate levels in patients using anti-hypertensives. Furthermore, to describe these changes and differences between the atenolol, hydrochlorothiazide plus amiloride and placebo arms of the Medical Research Council (MRC) elderly randomised controlled trial.MethodsPatients were randomly allocated to one of the three treatment arms. Measurements were taken at baseline, end of year one and end of year two in 4396 subjects. Linear Mixed Models (LMM) were used to determine the longitudinal profiles of sodium, potassium, weight, cholesterol, glucose, urea and urate. Estimates of changes within groups and difference between groups were obtained.ResultsPatients randomised to receive hydrochlorothiazide + amiloride experienced a significantly greater mean reduction in potassium, sodium and weight compared to placebo at end of year one - mean differences in change −0.18 mmol/L, (95 % CI: −0.21, −0.15); −1.45 mmol/L, (95 % CI: −1.62, −1.29) and −0.46 kgs (95 % CI: −0.73, −0.20) respectively, and greater increases in cholesterol, urea and urate - mean differences in change 0.16 mmol/L, (95 % CI: 0.10,0.22); 0.77 mmol/L, (95 % CI: 0.68, 0.87) and 53.10 μmol/L, (95 % CI: 49.35, 56.85) respectively. Changes were in the same direction but smaller in the atenololarm except for potassium and weight (increases). No group differences in glucose were found.ConclusionResults were in line with expectation except for lack of change in glucose in the hydrochlorothiazide + amiloride arms.Electronic supplementary materialThe online version of this article (doi:10.1186/s12872-016-0368-2) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 86%

Changes in selected metabolic parameters in patients over 65 receiving hydrochlorothiazide plus amiloride, atenolol or placebo in the MRC elderly trial

Damian

McNamee

Carr

2016

BMC Cardiovasc Disord

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Incorporation of Tetrazolium Blue (TB)/Gold Nanoparticles (GNPs) into Carbon Paste Electrode: Application as an Electrochemical Sensor for the Sensitive and Selective Determination of Sotalol in Micellar Medium

et al. 2017

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The electrochemical oxidation of Sotalol (SOT) based on Tetrazolium Blue (TB)/gold nanoparticles (GNPs)‐modified carbon paste electrodes (CPE) have been studied in the presence of sodium lauryl sulphate (SLS). Cyclic voltammetry (CV), differential pulse voltammetry (DPV), chronoamperometry and electrochemical impedance spectroscopy (EIS) techniques have all been utilized within this study. GNPs and TB have a synergetic effect‐giving rise to highly improved electrochemical responses and provide an advantageous platform for the basis of an electrochemical sensor with excellent performance. The experimental parameters, electrodeposition time, pH and scan rate have all been examined and optimized. The sensing of SOT via DPV is found to exhibit a wide linear dynamic range of 1.0×10−7–7.5×10−4 M in pH 2. LOD and LOQ were calculated and found to correspond to 2.5×10−8 M and 8.3×10−8 M, respectively. The suggested sensor has been used successfully for SOT determination in pharmaceutical samples and human urine as real samples. Satisfactory recoveries of analyte from these samples are demonstrated indicating that the suggested sensor is highly suitable for clinical analysis, quality control and a routine determination of SOT in pharmaceutical formulations.

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Determinants of serum uric acid levels in an adult general population: results from the Moli-sani Study

et al. 2020

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Elevated Serum Uric Acid Levels During Treatment With Antihypertensive Drugs

Cited by 14 publications

References 9 publications

Changes in selected metabolic parameters in patients over 65 receiving hydrochlorothiazide plus amiloride, atenolol or placebo in the MRC elderly trial

Changes in selected metabolic parameters in patients over 65 receiving hydrochlorothiazide plus amiloride, atenolol or placebo in the MRC elderly trial

Incorporation of Tetrazolium Blue (TB)/Gold Nanoparticles (GNPs) into Carbon Paste Electrode: Application as an Electrochemical Sensor for the Sensitive and Selective Determination of Sotalol in Micellar Medium

Determinants of serum uric acid levels in an adult general population: results from the Moli-sani Study

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