Elevated serum TC and LDL-C levels in Alzheimer’s disease and mild cognitive impairment: A meta-analysis study

Liu, Yang; Zhong, Xin; Shen, Jiajia; Jiao, Linchi; Tong, Junhui; Zhao, Wenxia; Du, Ke; Gong, Shiqiang; Liu, Mingyan; Wei, Minjie

doi:10.1016/j.brainres.2019.146554

Cited by 68 publications

(73 citation statements)

References 36 publications

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“…Alzheimer’s disease (AD) is the most common neurodegenerative disorder resulting in cognitive impairment. AD is characterized by a gradual decline in memory and other cognitive and executive functions, and the progressive development of affective and behavioral disorders [ 1 ]. The onset of AD is insidious, and its progression is gradual.…”

Section: Introductionmentioning

confidence: 99%

“…Disorders of lipid homeostasis are common risk factors for cardiovascular disease, which is linked to AD [ 9 ]. Dyslipidemia has been identified as a risk factor for AD [ 1 ]. This concept refers to abnormal levels of lipids or lipoproteins in the blood, which include high levels of low-density lipoprotein (LDL-C), low levels of high-density lipoprotein (HDL-C), total cholesterol (TC) and triglycerides (TG) [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

“…Dyslipidemia has been identified as a risk factor for AD [ 1 ]. This concept refers to abnormal levels of lipids or lipoproteins in the blood, which include high levels of low-density lipoprotein (LDL-C), low levels of high-density lipoprotein (HDL-C), total cholesterol (TC) and triglycerides (TG) [ 1 ]. According to previous results, the overall performance of four independent test results should be considered indexes for the prediction of AD, and provide accurate information on an individual’s lipid metabolism status or serum lipid and cholesterol levels [ 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

“…In the last ten years, the relationship between cholesterol and AD has been extensively investigated, especially in longitudinal epidemiological studies [ 10 ]. Evidence suggests that there is a relationship between having high cholesterol levels in blood in mid- and late-life and the development of dementia [ 1 , 13 ]. Specifically, some studies have demonstrated that dyslipidemia, mainly a high level of LDL-C, has vascular and neurotoxic effects, and is implicated in the pathogenesis of AD [ 10 , 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

“…Other studies share the same finding [ 21 , 22 ]. However, some studies did not find an association between high triglycerides levels and high levels of HDL-Cproteins and AD [ 1 , 12 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

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Cholesterol and Alzheimer’s Disease Risk: A Meta-Meta-Analysis

et al. 2020

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Background: Alzheimer’s disease (AD) is the most common subtype of dementia. In the last ten years, the relationship between cholesterol and AD has been investigated. Evidence suggests that cholesterol is associated with AD and represents promising targets for intervention. However, the causality of these associations is unclear. Therefore, we sought to conduct a meta-meta-analysis to determine the effect of cholesterol on the development AD. Then, we assessed the effect of serum levels of low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC) and triglycerides (TG), on AD risk. Methods: A systematic search of meta-analyses was conducted. Scopus, Web of Science, Science direct, PubMed and Google academic system databases were reviewed. Results: We found 100 primary studies and five meta-analyses to analyze the relationships between cholesterol and AD. The total effect of cholesterol on risk of AD was significant and heterogeneous. Subgroup analysis shows that LDL-C levels influence the development of AD. However, non-significant effects of HDL-C, TC and TG levels on AD were found. Conclusions: These results strengthen the evidence that LDL-C cholesterol levels increase risk for AD. More initiatives to investigate the relationship between cholesterol and AD are needed.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cholesterol and Alzheimer’s Disease Risk: A Meta-Meta-Analysis

et al. 2020

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Novel insights into brain lipid metabolism in Alzheimer's disease: Oligodendrocytes and white matter abnormalities

Kawade

Yamanaka

2023

FEBS Open Bio

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Alzheimer's disease (AD) is the most common cause of dementia. A genome‐wide association study has shown that several AD risk genes are involved in lipid metabolism. Additionally, epidemiological studies have indicated that the levels of several lipid species are altered in the AD brain. Therefore, lipid metabolism is likely changed in the AD brain, and these alterations might be associated with an exacerbation of AD pathology. Oligodendrocytes are glial cells that produce the myelin sheath, which is a lipid‐rich insulator. Dysfunctions of the myelin sheath have been linked to white matter abnormalities observed in the AD brain. Here, we review the lipid composition and metabolism in the brain and myelin and the association between lipidic alterations and AD pathology. We also present the abnormalities in oligodendrocyte lineage cells and white matter observed in AD. Additionally, we discuss metabolic disorders, including obesity, as AD risk factors and the effects of obesity and dietary intake of lipids on the brain.

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Research advances in the influence of lipid metabolism on cognitive impairment

Zhang

Zhu

2022

Ibrain

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Cognitive impairment (CI) is a mental disorder related to cognition and understanding, which is mainly categorized into mild CI and senile dementia. This disease is associated with multiple factors, such as chronic brain injury, aging, chronic systemic disease, mental state, and psychological factors. However, the pathological mechanism of CI remains unclear; it is usually associated with such underlying diseases as diabetes and hyperlipidemia. It has been demonstrated that abundant lipid metabolism indexes in the human body are closely related to CI, including total cholesterol, high‐density lipoprotein cholesterol, low‐density lipoprotein cholesterol, triglycerides, apolipoprotein, and so forth. As a crucial risk factor for CI, hyperlipidemia is of great significance in the occurrence and development of CI. However, the specific correlation between dyslipidemia and CI is still not fully elucidated. Besides, the efficacy of lipid‐lowering drugs in the prophylaxis and treatment of CI has not been clarified. In this study, relevant advances in the influence of lipid metabolism disorders in CI will be reviewed, in an attempt to explore the effect of mediating blood lipid levels on the prophylaxis and treatment of CI, thus providing a reference for its clinical management.

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Elevated serum TC and LDL-C levels in Alzheimer’s disease and mild cognitive impairment: A meta-analysis study

Cited by 68 publications

References 36 publications

Cholesterol and Alzheimer’s Disease Risk: A Meta-Meta-Analysis

Cholesterol and Alzheimer’s Disease Risk: A Meta-Meta-Analysis

Novel insights into brain lipid metabolism in Alzheimer's disease: Oligodendrocytes and white matter abnormalities

Research advances in the influence of lipid metabolism on cognitive impairment

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