Research advances in the influence of lipid metabolism on cognitive impairment

Abstract

Cognitive impairment (CI) is a mental disorder related to cognition and understanding, which is mainly categorized into mild CI and senile dementia. This disease is associated with multiple factors, such as chronic brain injury, aging, chronic systemic disease, mental state, and psychological factors. However, the pathological mechanism of CI remains unclear; it is usually associated with such underlying diseases as diabetes and hyperlipidemia. It has been demonstrated that abundant lipid metabolism indexes in the human body are closely related to CI, including total cholesterol, high‐density lipoprotein cholesterol, low‐density lipoprotein cholesterol, triglycerides, apolipoprotein, and so forth. As a crucial risk factor for CI, hyperlipidemia is of great significance in the occurrence and development of CI. However, the specific correlation between dyslipidemia and CI is still not fully elucidated. Besides, the efficacy of lipid‐lowering drugs in the prophylaxis and treatment of CI has not been clarified. In this study, relevant advances in the influence of lipid metabolism disorders in CI will be reviewed, in an attempt to explore the effect of mediating blood lipid levels on the prophylaxis and treatment of CI, thus providing a reference for its clinical management.

Investigation of the shared biological mechanisms and common biomarker APTAF1 of sleep deprivation and mild cognitive impairment using integrated bioinformatics analysis

“…In addition, among the 32 MitoDEGs involved in metabolism, 11 genes are implicated, including six in lipid metabolism (ACADL, THEM4, ACSM3, LYPLA1, TSPO, and SCP2), one in carbohydrate metabolism (HMGCL), one in amino acid metabolism (GLS2), and one in nucleotide metabolism (FHIT), ( Figure 8B ). Notably, it has been demonstrated that lipid metabolism disorders are closely related to cognitive function, as evidenced by the observation that knockout of a key enzyme in mitochondrial fatty acid oxidation causes cognitive impairment ( Zhang et al, 2022 ; Morant-Ferrando et al, 2023 ). Importantly, our findings shed light on the role of metabolism, especially lipid metabolism, in the cognitive impairment induced by SD.…”