Elevated serum lipoprotein(a) is significantly associated with angiographic progression of coronary artery disease

Abstract

Background Lipoprotein(a)[Lp(a)] has been considered as an independent risk factor for coronary artery disease (CAD). The present study aimed to evaluate the association between baseline serum Lp(a) and CAD progression determined by angiographic score. Methods A total of 814 patients who had undergone two or more coronary computed tomography angiography at least 6 months apart were consecutively enrolled and the coronary severity was determined by the Gensini score system. Patients were stratified into two groups according to Lp(a)>300 mg/L and Lp(a) ≤ 300 mg/L or classified as “progressors” and “non‐progressors” based on the Gensini score rate of change per year. The association of continuous Lp(a) and Lp(a)>300 mg/L with CAD progression were respectively assessed by logistic regression analysis. Moreover, further evaluation of those association was performed in subgroups of the study population. Results Patients in the “progressors” group had significant higher Lp(a) levels. Furthermore, the multivariate logistic regression analysis showed that elevated Lp(a) (odds ratio [OR]: 1.451, 95% confidence interval [CI]: 1.177–1.789, p<.001) and Lp(a)>300 mg/L (OR:1.642, 95% CI:1.018–2.649, p = .042) were positively associated with CAD progression after adjusting for confounding factors. In addition, those relation seemed to be more prominent in subjects with lower body mass index (OR: 1.880, 95% CI: 1.224–2.888, p for interaction = .060). Conclusions Elevated baseline serum Lp(a) is positively and independently associated with angiographic progression of CAD, particularly in participants with relatively low body mass index. Therefore, Lp(a) could be a potent risk factor for CAD progression, assisting in early risk stratification in cardiovascular patients.

Correlation between Lpa, APO-A, APO-B, and Stenosis of Middle Cerebral Artery in Patients with Cerebral Ischemic Stroke

“…The results showed that the levels of Lpa and APO-B in CIS patients were positively correlated with the degree of MCA stenosis, and the APO-A level was negatively correlated with the degree of MCA stenosis. It has been reported by Shui et al [ 22 ] that the increase in Lpa is positively correlated with the progression of coronary artery disease. Yaseen et al [ 23 ] reported that APO-B was positively correlated with the degree of coronary artery disease.…”

Unraveling the Association Between Lipoprotein(a) and Cardiovascular Events With Coronary Computed Tomography Angiography

“…6 In addition, Lp(a) was shown to be associated with progression of coronary artery plaque assessed with a semiquantitative CCTA score, independent of cardiovascular risk factors. 7 CCTA has also provided insight in to the relationship between Lp(a) levels and coronary plaque progression demonstrating that Lp(a) is associated with progression of low attenuation plaque (necrotic core), but not total, calcified, or noncalcified plaque. 8 In the current study, limited quantitative plaque analysis was performed with only total plaque burden and not the burden of the different plaque subtypes assessed.…”

To explore the causal association between the serum lipid profile and inflammatory bowel disease using bidirectional Mendelian randomisation analysis

“…2 Previous studies have confirmed that patients with IBD present with dyslipidaemia, 3 4 which is a well-established risk factor for cardiovascular disease. Several studies have shown that lower total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (Apo B) and apolipoprotein A-I (Apo A-I) levels are associated with higher triglyceride (TG) and lipoprotein (a) (Lp(a)) levels in patients with IBD, [5][6][7][8][9][10] which are independently associated with more severe disease. 7 9 10 Additionally, compared with the general population, male patients with IBD have higher TG levels, while female patients with IBD have significantly lower TG levels.…”