Elevated Serum Immunoglobulin G Titers Against Chlamydia pneumoniae in Primary Open-Angle Glaucoma Patients Without Systemic Disease

Yuki, Kenya; Kimura, Ikuo; Shiba, Daisuke; Imamura, Yutaka; Tsubota, Kazuo

doi:10.1097/ijg.0b013e3181ca7868

Cited by 7 publications

(3 citation statements)

References 56 publications

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“…A signifi cant increase of H. pylori IgG antibody levels was demonstrated, suggesting that the titer of anti-H. pylori IgG antibody in the AH might refl ect the severity of glaucomatous damage in POAG patients. Yuki et al analyzed the serum of POAG patients for Chlamydia pneumoniae and Chlamydia trachomatis immunoglobulin G antibody titers by ELISA, and found significantly higher immunoglobulin G titers for C. pneumoniae in POAG patients than in controls (39) . This may indicate either a common factor that causes susceptibilities to both glaucoma and C. pneumoniae infection, or that C. pneumoniae may be a causal factor for developing POAG (39) .…”

Section: Antibodiesmentioning

confidence: 99%

Biomarkers in primary open angle glaucoma

Kokotas

Kroupis

Chiras

et al. 2012

Clinical Chemistry and Laboratory Medicine (CCLM)

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Glaucoma, a leading cause of blindness worldwide, is currently defi ned as a disturbance of the structural or functional integrity of the optic nerve that causes characteristic atrophic changes in the optic nerve, which may lead to specifi c visual fi eld defects over time. This disturbance usually can be arrested or diminished by adequate lowering of intraocular pressure (IOP). Glaucoma can be divided roughly into two main categories, ' open angle ' and ' closed angle ' glaucoma. Open angle, chronic glaucoma tends to progress at a slower rate and patients may not notice loss of vision until the disease has progressed signifi cantly. Primary open angle glaucoma (POAG) is described distinctly as a multifactorial optic neuropathy that is chronic and progressive with a characteristic acquired loss of optic nerve fi bers. Such loss develops in the presence of open anterior chamber angles, characteristic visual fi eld abnormalities, and IOP that is too high for the healthy eye. It manifests by cupping and atrophy of the optic disc, in the absence of other known causes of glaucomatous disease. Several biological markers have been implicated with the disease. The purpose of this study was to summarize the current knowledge regarding the non-genetic molecular markers which have been predicted to have an association with POAG but have not yet been validated.

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Section: Antibodiesmentioning

confidence: 99%

Biomarkers in primary open angle glaucoma

Kokotas

Kroupis

Chiras

et al. 2012

Clinical Chemistry and Laboratory Medicine (CCLM)

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“…However, there are several studies showing that C. pneumoniae is associated with various systemic diseases. Yuki et al (32) noticed that higher C. pneumoniae titers are associated with POAG (primary open-angle glaucoma). In another study, Miao et al (33) showed that TLR2/CXCR4 co-association makes easier C. pneumoniae infection-stimulated speed-up of atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

Investigation of Possible Role of Chlamydia in Pseudoexfoliation Syndrome

Gonca

Serin

Yılmaz³

et al. 2021

Jundishapur J Microbiol

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Background: Pseudoexfoliation syndrome (PES) is a systemic disease characterized by the aggregation of fibrillar extracellular material in intraocular and extraocular tissues with unknown etiology. Clarifying the etiopathogenesis of PES would be important for public health. Objectives: We aimed to investigate the possible role of Chlamydia in the etiology of PES. Methods: This cross-sectional study was carried out in the ophthalmology clinic of a tertiary hospital. The study included two groups, including the patient group (PES patients with nuclear cataracts) and the control group (patients with nuclear cataracts). Patients with other ophthalmic problems and systemic diseases were excluded. Blood samples and conjunctival swabs taken from 49 patients and 42 controls were used in the study. Anti-Chlamydia trachomatis IgG and IgM, anti-C. pneumoniae IgG and IgM, Interleukin (IL)-6, and IL-20 were studied in the serum samples. The PCR study was performed with conjunctival swab samples and sequence analysis of PCR-positive samples was performed. Results: According to the results of the study, there was no statistically significant difference between the groups in terms of anti-C. trachmatis IgG, anti-C. trachmatis IgM, anti-C. pneumoniae IgM, IL-6, and PCR results. There was a statistically significant difference between patient and control groups in terms of anti-C. pneumoniae IgG and IL-20 levels. The DNA sequencing of all PCR products was found to be compatible with C. pneumoniae. Conclusions: It seems that C. pneumoniae might have an important role in the etiology and development of PES. However, further studies in larger groups are needed to clarify these results.

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“…Immunoglobulin serology for CP is significantly higher in patients with glaucoma compared to controls (Yuki et al, 2010 ). Other infections noted in association with glaucoma include: Helicobacter pylori (Galloway et al, 2003 ), Bartonella henselae (Gray et al, 2004 ), HIV (Nash and Lindquist, 1992 ), CMV (Sekhsaria et al, 1992 ), Toxoplasmosis (Sheets et al, 2009 ), Tuberculosis (Egbagbe and Omoti, 2008 ), and Lyme disease (Zaidman, 1997 ).…”

Section: Middle Life Signs and Susceptibility To Future Admentioning

confidence: 99%

It’s Never Too Early or Too Late—End the Epidemic of Alzheimer’s by Preventing or Reversing Causation From Pre-birth to Death

Trempe¹,

Lewis²

2018

Front. Aging Neurosci.

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The path to sporadic Alzheimer’s is a tragic journey beginning prior to birth and ending in the most dreaded disease of society. Along the disease path are a myriad of clues that portend AD, many of which are complaints of seemingly unrelated conditions from chronic migraines, mood disorders, eye diseases, metabolic syndromes, periodontal diseases, hormonal and autoimmune diseases. Properly treating, not just managing, these diseases, prior to onset of dementia, may significantly reduce dementia incidences. Current high levels of health complaints reflect a state of generalized poor health and compromised immunity. During the mid-Victorian era, people were long-lived yet healthy, suffering from chronic diseases at one tenth the rate of peoples today. It’s our poor health, at any age that increases susceptibility to chronic diseases and Alzheimer’s. Infection is involved in many cases of Alzheimer’s and other neurodegenerative diseases but is also implicated in many chronic conditions. Scientists looking for causation recognize that Alzheimer’ is multifactorial and systemic—not “brain only.” To slow, stop and reverse the AD epidemic, identification and reversal of causal factors must occur across the entire life spectrum of humans. This approach simply gives consideration to enhancing immune status of our bodies and brain, and controlling inflammation and infection, throughout the entire age spectrum. Infection is a causal factor, but the root cause is multi-factorial and immune health related. Pasteur stated it best when acknowledging the work of Bernard in 19th Century France, “The seed is nothing, the soil is everything.”

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Elevated Serum Immunoglobulin G Titers Against Chlamydia pneumoniae in Primary Open-Angle Glaucoma Patients Without Systemic Disease

Abstract: The results suggest that higher C. pneumoniae titers are associated with POAG. If confirmed, this may indicate either a common factor that causes susceptibilities to both glaucoma and C. pneumoniae infection or that C. pneumoniae may be a causal factor for developing POAG.

Cited by 7 publications

References 56 publications

Biomarkers in primary open angle glaucoma

Biomarkers in primary open angle glaucoma

Investigation of Possible Role of Chlamydia in Pseudoexfoliation Syndrome

It’s Never Too Early or Too Late—End the Epidemic of Alzheimer’s by Preventing or Reversing Causation From Pre-birth to Death

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