Elevated serum homocysteine level has a positive correlation with serum cardiac troponin I in patients with acute myocardial infarction

Alam, Nur; Khan, Hilr; Chowdhury, AW; Haque, Mahmudul; Ali, Maaruf; Sabah, Kmn; Amin, Mohammad Al

doi:10.3329/bmrcb.v38i1.10445

Cited by 17 publications

(9 citation statements)

References 8 publications

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“…This result was supported by the study of Alam et al 25 that 92.8% of their series of patients were male and 7.2% patients were female. Shirin et al 24 reported that 80.0% of their series were male and 20.0% of patients were female.…”

Section: Materials and Methodsupporting

confidence: 79%

Relationship between HDL-Cholesterol and Angiographic Severity of Coronary Artery Disease

Ahmed

Akhtaruzzaman²,

Rahman

et al. 2018

Bangladesh Heart J

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Abstract:Background: Dyslipidaemias is one of the major risk factor for Coronary artery diseases (CAD).There is an inverse correlation between high density lipoprotein cholesterol (HDL-C) and the risk of coronary artery disease. Understanding the angiographic characteristics of coronary artery diseases (CAD) in low and normal HDL-C patients and its association with severity of CAD is very important for future intervention. Although highdensity lipoprotein cholesterol (HDL-C) is well established predictor of future cardiovascular event, little information is available regarding its correlation with the prevalence and severity of angiographically evaluated coronary artery diseases (CAD). Conclusion: It may be concluded that low HDL-C level is associated with angiographically more severe coronary artery diseases reflected by vessels score and Friesinger score as compared to normal or high HDL-C level.

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Section: Materials and Methodsupporting

confidence: 79%

Relationship between HDL-Cholesterol and Angiographic Severity of Coronary Artery Disease

Ahmed

Akhtaruzzaman²,

Rahman

et al. 2018

Bangladesh Heart J

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“…Elevated levels of serum homocysteine may result from geographical variations, racial and ethnic differences, genetic causes, different lifestyle, inadequate intake of B vitamins and folate in the diet, inaccurate cooking of vegetables and not implementing fortification of grain products with folic acid . 24 Our study showed high TG (198.96±116.71 mg/dl) and low HDL (34.23±8.26 mg/dl) in the study population. HDL had significant inverse correlation with serum tHcy.…”

Section: Discussionsupporting

confidence: 48%

Serum Homocysteine and its Association with Lipid Profile in Type 2 Diabetic Patients

Majumder

Mollah

Fariduddin

et al. 2018

J Shaheed Suhrawardy Med Coll

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Background: Diabetes accounts for almost 6% of total global mortality, with 50% of diabetesassociated deaths being attributed to cardiovascular disease (CVD). Prevalence of type 2 diabetes in rural Bangladeshi and in urban Bangladeshi is found to be 7.2% and 10.5% respectively. People of developing countries suffer from the disease at earlier age than that of developed countries. Among the diabetic patients, vascular complications represent a major cause of morbidity and mortality. Diabetes is commonly accompanied by other cardiovascular risk factors: dyslipidemia, hypertension, and increased prothrombotic factors. Total plasma homocysteine (tHcy) is an emerging CVD risk factor. Insulin resistance and hyperinsulinemia in diabetes mellitus along with increased homocysteine is thought to cause endothelial dysfunction. Endothelial dysfunction together with other factors such as dyslipidemia, microalbuminemia etc. causes cardiovascular disease.Objectives: Objective of the study was to evaluate serum total homocysteine level and to correlate it with fasting lipid profile in type 2 diabetic patients.Methodology: This cross sectional study was conducted during the period of July 2011- June 2013 on 95 patients of type 2 diabetes mellitus, attending the Endocrine OPD of Bangabandhu Sheikh Mujib Medical University (BSMMU). The study was carried out in the Department of Biochemistry, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka. Study subjects were selected by purposive and convenient sampling technique.Result: Study subjects were categorized according to the presence or absence of hyperhomocysteinemia. Among the total study population hyperhomocysteinemia was found in 21.05 %. Among them number of male was greater. The study population had mean serum total cholesterol 198.34±39.62(mg/dl), triacylglycerol 198.91±116.71(mg/dl), LDL 126.75±35.38(mg/ dl), HDL 34.35±8.31(mg/dl), TC:HDL=15.67±6.07:1,and LDL:HDL=9.94±3.88:1 Independant sample t test showed that there was significant inverse association of hyperhomocysteinemia with HDL. Other parameters of lipid profile and lipid ratios did not show any significant association.Conclusions: Around one fifth of the type 2 diabetic patients had hyperhomocysteinemia. Significant inverse association was present between hyperhomocysteinemia and HDL. Other parameters of lipid profile and lipid ratios did not show any significant association.J Shaheed Suhrawardy Med Coll, June 2018, Vol.10(1); 42-46

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“…During the last two decades, extensive experimental evidence, both in vitro and in vivo, indicates that Hcy is an independent risk factor for cardiovascular disease and elevated serum Hcy level is associated with CAD events [28–30]. Homocysteine Studies Collaboration research revealed that elevated approximately 3 μmol/L Hcy will increase about 10% risk of cardiovascular events [31].…”

Section: Discussionmentioning

confidence: 99%

Serum high concentrations of homocysteine and low levels of folic acid and vitamin B12 are significantly correlated with the categories of coronary artery diseases

Peng

Liu

et al. 2017

BMC Cardiovasc Disord

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BackgroundHomocysteine (Hcy) has been considered as an independent risk factor for coronary artery disease (CAD). Folic acid and vitamin B12 are two vital regulators in Hcy metabolic process. We evaluated the correlations between serum Hcy, folic acid and vitamin B12 with the categories of CAD.MethodsSerum Hcy, folic acid and vitamin B12 from 292 CAD patients, including 73 acute myocardial infarction (AMI), 116 unstable angina pectoris (UAP), 103 stable angina pectoris (SAP), and 100 controls with chest pain patients were measured, and the data were analyzed by SPSS software.ResultsCompared to SAP patients, patients with AMI and UAP had higher Hcy levels with approximately average elevated (4-5) μmol/L, while SAP patients were approximately higher 8 μmol/L than controls. However, the levels of folic acid and vitamin B12 had opposite results, which in AMI group was the lowest, while in controls was the highest. CAD categories were positively correlated with Hcy (r = 0.286, p < 0.001), and negatively correlated with folic acid (r = -0.297, p < 0.001) and vitamin B12 (r = -0.208, p < 0.001). There were significant trend toward increase in the prevalence of high Hcy, low folic acid and vitamin B12 from controls, to SAP, to UAP, and to AMI.ConclusionsThe present study provide the valuable evidence that high concentrations of Hcy and low levels of folic acid and vitamin B12 are significantly correlated with CAD categories.

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Elevated serum homocysteine level has a positive correlation with serum cardiac troponin I in patients with acute myocardial infarction

Cited by 17 publications

References 8 publications

Relationship between HDL-Cholesterol and Angiographic Severity of Coronary Artery Disease

Relationship between HDL-Cholesterol and Angiographic Severity of Coronary Artery Disease

Serum Homocysteine and its Association with Lipid Profile in Type 2 Diabetic Patients

Serum high concentrations of homocysteine and low levels of folic acid and vitamin B12 are significantly correlated with the categories of coronary artery diseases

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