Elevated serum anti-mullerian hormone in adolescent and young adult Chinese patients with polycystic ovary syndrome

Li, Lin; Chen, Xiaoli; Mo, Yujun; Chen, Yaxiao; Wenig, M; Yang, Dongzi

doi:10.1007/s00508-010-1426-x

Cited by 43 publications

(31 citation statements)

References 25 publications

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“…Our findings were compatible with the previously published literature, showing that serum AMH levels are slightly higher in females with PCOS [20] and that a significant positive correlation between serum AMH and HOMA-IR levels is present in these adolescents [21]. The present study also indicates that insulin may have a direct effect on AMH synthesis in granulosa cells.…”

Section: Discussionsupporting

confidence: 95%

Association between anti-Mullerian hormone and insulin resistance in non-obese adolescent females with polycystic ovary syndrome

Tokmak

Kokanalı

Tımur

et al. 2016

Gynecological Endocrinology

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Section: Discussionsupporting

confidence: 95%

Association between anti-Mullerian hormone and insulin resistance in non-obese adolescent females with polycystic ovary syndrome

Tokmak

Kokanalı

Tımur

et al. 2016

Gynecological Endocrinology

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“…In recent years, AMH has been recommended for diagnosing PCOS, but in practice there are great discrepancies in the diagnostic power [17,18,24]. In the present study, the diagnostic sensitivity and specificity of AMH was not satisfying, suggesting that sole use of AMH is not adequate for diagnosing PCOS because of its low accuracy.…”

Section: Discussioncontrasting

confidence: 70%

“…According to Pigny et al [24], the diagnostic specificity reached 92 % and the sensitivity reached 67 % if a serum level of 60 pmol/L was set as the cut-off value. However, Li et al [17] reported that the diagnostic specificity was only 70 % and the sensitivity was only 61.7 % when AMH was used for the diagnosis of PCOS patients. Hart et al [13] reported that the specificity of AMH in predicting PCOS in adolescent patients was <70 % and the sensitivity was only 50 %.…”

Section: Introductionmentioning

confidence: 99%

Different diagnostic power of anti-Mullerian hormone in evaluating women with polycystic ovaries with and without hyperandrogenism

Li¹,

Ma²,

Chen³

et al. 2012

J Assist Reprod Genet

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Purpose The aim of this study is to compare the secretory profiles and diagnostic power of anti-Mullerian hormone (AMH) for the PCOS patient with and without hyperandrogenism. Methods One hundred and thirty-one PCOS patients with oligomenorrhea or amenorrhea were recruited into the study. Sixty-two and sixty-nine patients had and did not have hyperandrogenism (HA+) hyperandrogenism (HA−), respectively. Sera were collected for determining the levels of AMH, basal sexual hormones, glucose and lipid metabolic indicators. Results The AMH serum levels of PCOS patients were significantly higher than the control group, with the highest AMH serum level in the HA+ group. The cut-off value for predicting PCOS patients of all types was 3.92 ng/mL, with a sensitivity of 65 %, and specificity of 62 %. The cut-off value for predicting PCOS patients in the HA+ group was 4.23 ng/mL, with a sensitivity of 82 %, and specificity of 64 %. The cut-off value for predicting PCOS patients in the HA− group was 3.76 ng/mL, with a sensitivity of 64 %, and specificity of 62 %. In the HA+ group, AMH was negatively associated with FSH and positively associated with LH. In the HA− group, AMH was negatively associated with HDL and positively associated with BMI, fasting glucose and LDL.Conclusions AMH is only suitable for predicting the PCOS patients with hyperandrogenism. The diagnostic power of AMH is limited when used to predict patients without hyperandrogenism. It reflects the differences in pathophysiology and severity of disrupted folliculogenesis between the two subtypes.

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“…Therefore, serum AMH levels increase by 2-3-fold in women with early stage PCOS compared with normal controls. The sensitivity of serum AMH for diagnosis of PCOS ranges from 64 to 99 % [60][61][62][63][64][65][66][67][68]. The wide range of sensitivities among studies is likely due to variations in diagnostic criteria and in the age of the patient population.…”

Section: Diagnosis Of Polycystic Ovary Syndrome (Pcos)mentioning

confidence: 99%

Anti‐Müllerian hormone as a marker of ovarian reserve: What have we learned, and what should we know?

Iwase

Nakamura

Osuka

et al. 2015

Reprod Medicine & Biology

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Ovarian reserve reflects the quality and quantity of available oocytes. This reserve has become indispensable for the better understanding of reproductive potential. Measurement of the serum anti-Müllerian hormone (AMH) level allows quantitative evaluation of ovarian reserve. It has been applied to a wide range of clinical conditions, and it is well established that the measurement of serum AMH levels is more useful than qualitative evaluation based on the menstrual cycle. AMH levels are monitored during infertility treatments; in patients undergoing medically assisted reproductive technology; and in the diagnosis of ovarian failure, polycystic ovarian syndrome, and granulosa cell tumor. It is also useful in the evaluation of iatrogenic ovarian damage. Population-based studies have indicated a potential role for serum AMH in the planning of reproductive health management. While AMH is currently the best measure of ovarian reserve, its predictive value for future live births remains controversial. Furthermore, there is a serious practical issue in the interpretation of test results, as currently available assay kits use different assay ranges and coefficients of variation due to the absence of an international reference standard. The pros and cons of the serum AMH level as a definitive measure of ovarian reserve merits further review in order to guide future research.

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Elevated serum anti-mullerian hormone in adolescent and young adult Chinese patients with polycystic ovary syndrome

Abstract: Serum AMH levels are elevated in adolescent and young adult Chinese patients of PCOS. Serum AMH measurement offers a relatively poor diagnostic potency with a sensitivity of 61.7% and a specificity of 70% at 8 ng/mL.

Cited by 43 publications

References 25 publications

Association between anti-Mullerian hormone and insulin resistance in non-obese adolescent females with polycystic ovary syndrome

Association between anti-Mullerian hormone and insulin resistance in non-obese adolescent females with polycystic ovary syndrome

Different diagnostic power of anti-Mullerian hormone in evaluating women with polycystic ovaries with and without hyperandrogenism

Anti‐Müllerian hormone as a marker of ovarian reserve: What have we learned, and what should we know?

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