“…Suggested links include chronic inflammation, mitochondrial dysfunction,, Th17-induced neutrophilia, macrophage dysregulation, hormonal changes, lipid metabolism, insulin resistance, and body mechanics (Baffi et al, 2016; Chesne et al, 2014; Shore and Cho, 2016). Other well-described abnormalities in obesity and metabolic syndrome, accelerated formation of advanced glycation end products (AGEs) and alterations in arginine metabolism may also play a crucial role in asthma pathogenesis and may be modulated by the anti-inflammatory incretin, GLP-1 (Figure 1) (Holguin, 2013; Milutinovic et al, 2012; Ojima et al, 2013; Singh et al, 2015; Uribarri et al, 2015). …”