Could Advanced Glycation End Products Explain the Poor Response to Controlled Ovarian Hyperstimulation in Obese Women?

Zhang, John J.; Merhi, Zaher

doi:10.15226/2374-6890/3/2/00146

Cited by 3 publications

(5 citation statements)

References 79 publications

(111 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Higher humidity, lower temperatures, and low pH also make minor contributions to the [15]. AGEs: advanced glycation end products formation of AGEs [17]. Table 9.1 shows the differences between food groups and cooking methods that contribute to low or high levels of AGEs [4,[18][19][20][21].…”

Section: Sources Of Agesmentioning

confidence: 99%

“…Dietary AGEs are reportedly absorbed in circulation mostly in the form of free AGEs eg. CML (by simple diffusion) and peptide bound AGEs following gastrointestinal digestion [8] and thereafter, they can get deposited in various tissues [17].…”

Section: Absorptionmentioning

confidence: 99%

“…Approximately 10-30% of dietary AGEs are absorbed into the systemic circulation [8], one third of which is excreted by the kidneys while two-thirds linger in the body, contributing to the body's AGEs pool and which binds to several tissues [17,22]. Therefore, decreased intake of dietary AGEs has been associated with approximately 40% decreases in the levels of AGEs in the body [8].…”

Section: Absorptionmentioning

confidence: 99%

“…Supporting evidence from studies that were carried out have implicated dietary AGEs in the pathogenesis of obesity [17,25,26]. In fact, it has been suggested that increased consumption of processed foods in the last 50 years may have favoured increased consumption of dietary AGEs, leading to increased development of obesity, and its mediated complications in the world's population [4,27].…”

Section: Dietary Ages and Obesitymentioning

confidence: 99%

“…In a study that was conducted in rats, high-AGEs diet reportedly increased serum levels of AGEs and upregulated ovarian RAGE. These effects were reversed following consumption of a low-AGE diet, administration of an AGE blocker and the use of orlistat (obesity suppressing drug) [17,28,29]. To examine the relationship between methylglyoxal accumulation and the development of obesity, Jia et al [3] compared methylglyoxal accumulation in the white fat tissues from Zucker lean and obese rats.…”

Section: Dietary Ages and Obesitymentioning

confidence: 99%

See 4 more Smart Citations

Dietary Advanced Glycation End Products as Mediators of Obesity: Cellular and Molecular Mechanisms of Action

Eleazu

Nna

Suleiman

et al. 2021

Cellular and Biochemical Mechanisms of Obesity

View full text Add to dashboard Cite

Obesity, a disorder of body weight regulatory systems that is characterized by the accumulation of excess body fat is increasingly becoming a global pandemic. Despite several approaches that have been applied to mitigate obesity, they have not been able to totally reverse the obesity and its mediated complication. Advanced glycation end products (AGEs) refer to a group of prooxidant heterogenous compounds whose formation results from nonenzymatic reactions between reactive sugars and proteins, lipids and nucleic acids. While supporting evidence has suggested that AGEs may have contributory roles in the pathogenesis of obesity, there are indications that increased consumption of dietary AGEs increases the circulating AGEs levels and their deposition in the tissues including the adipose tissue, increasing the risk of development of obesity and its comorbidities. Identification of the underlying mechanism may provide an important strategy for novel therapeutic approaches against obesity. This chapter therefore provided novel insights into the role of dietary AGEs in the pathogenesis of obesity and the purported mechanisms of action.

show abstract

Section: Sources Of Agesmentioning

confidence: 99%

Section: Absorptionmentioning

confidence: 99%

Section: Absorptionmentioning

confidence: 99%

Section: Dietary Ages and Obesitymentioning

confidence: 99%

Section: Dietary Ages and Obesitymentioning

confidence: 99%

See 3 more Smart Citations

Dietary Advanced Glycation End Products as Mediators of Obesity: Cellular and Molecular Mechanisms of Action

Eleazu

Nna

Suleiman

et al. 2021

Cellular and Biochemical Mechanisms of Obesity

View full text Add to dashboard Cite

show abstract

Oxidative stress and female infertility: the role of follicular fluid soluble receptor of advanced glycation end-products (sRAGE) in women with endometriosis

Sopasi,

Spyropoulou,

Kourti

et al. 2023

Human Fertility

View full text Add to dashboard Cite

Importance of the Glycated Hemoglobin Assay in Congolese Women with Polycystic Ovary Syndrome: A Case-Control Study in Kinshasa, DR Congo

Numbi¹,

Beya²,

Luzolo³

et al. 2019

OJOG

View full text Add to dashboard Cite

Context: Polycystic ovary syndrome (PCOS) is considered a syndrome related to the metabolic syndrome with a high risk for developing diabetes mellitus. The evaluation of the glycated hemoglobin (HbA1c) seems to be an interesting tool to detect states of hyperglycemia that may be associated with this syndrome and to understand her pathophysiology. Aims: The purposes of this study are to determine the profile of HbA1c in Congolese women with PCOS, to determine the frequency of states of hyperglycemia and to assess the impact of this marker on clinical signs on this syndrome. Material and methods: This is a case-control study of 130 Congolese subfertile women; 65 with a diagnosis of PCOS and 65 others without PCOS. This is conducted from June 2016 to June 2019 among Congolese women of childbearing age.How to cite this paper:All these women were recruited at the subfertility outpatient clinic of the University Hospital of UNIKIN as well of the YANGA medical centers in Kinshasa, Democratic Republic of Congo. Sickle cell disease was excluded as also the cases of anemia. HbA1c was assayed via the immunoturbidimetric method and the results interpreted according to the ADA recommendations with a pathological cut-off point ≥ 6.5%. Results: Mean hemoglobin was 11.6 ± 1.2 g/dl (11.5 ± 1.1 g/dl vs. 11.8 ± 1.4 g/dl, P = 0.568). The proportion of diabetics was 1.6% (1.6% vs. 1.5%, P = 0.74). Higher HbA1c values were noted in the PCOS group compared to the control group (7.3% ± 2.1% vs. 5.6% ± 0.6%, P < 0.001). The multivariate analysis showed a strong correlation between elevated HbA1c levels and PCOS , P < 0.001). In the PCOS group, higher HbA1c values were significantly correlated with a higher socio-economic status ), P = 0.018) and with obesity (OR 3.48 IC (1.31 -7.13) P = 0.029). A perfect, positive and significant linear correlation was found between HbA1c and fasting blood glucose (r = 0.807). 60% of women in the PCOS group had pathological values of HbA1c (≥6.5%) compared to 7.7% in the control group (P < 0.001). Oligomenorrhea was found more significantly in patients with pathological HbA1c values (≥6.5%) compared to those with values < 6.5% (P = 0.003). Conclusion: This study found that in our population 60% of women with PCOS had states of hyperglycemia, demanding systematic screening of glucose metabolism disorders in women with this syndrome.

show abstract

Could Advanced Glycation End Products Explain the Poor Response to Controlled Ovarian Hyperstimulation in Obese Women?

Cited by 3 publications

References 79 publications

Dietary Advanced Glycation End Products as Mediators of Obesity: Cellular and Molecular Mechanisms of Action

Dietary Advanced Glycation End Products as Mediators of Obesity: Cellular and Molecular Mechanisms of Action

Oxidative stress and female infertility: the role of follicular fluid soluble receptor of advanced glycation end-products (sRAGE) in women with endometriosis

Importance of the Glycated Hemoglobin Assay in Congolese Women with Polycystic Ovary Syndrome: A Case-Control Study in Kinshasa, DR Congo

Contact Info

Product

Resources

About