Oxidative stress and female infertility: the role of follicular fluid soluble receptor of advanced glycation end-products (sRAGE) in women with endometriosis

Sopasi, Foteini; Spyropoulou, Isabella; Kourti, Marianthi; Vasileiadis, Stavros; Tripsianis, Grigorios; Galazios, Georgios; Koutlaki, Nikoleta

doi:10.1080/14647273.2023.2230360

Cited by 1 publication

(1 citation statement)

References 44 publications

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“…Overall, the background of alterations in oocyte quality in patients with endometriosis is slightly questionable as researchers have displayed doubtful attitudes about whether the damage caused to the oocytes is primary or occurs as a result of cells’ exposure to the toxic peritoneal fluid environment [ 29 ]. Most researchers have indirectly reported OS-related decreased oocyte quality in patients with endometriosis based on associations between increased concentrations of OS markers or reduced values of antioxidant biomarkers in the direct vicinity of oocytes, that is, follicular fluid or granulosa cells, and lower oocyte retrieval, the maturation of oocytes, and in vitro fertilization or pregnancy outcomes [ 30 , 31 , 32 ]. To date, the potential mechanisms responsible for this state have not been sufficiently investigated.…”

Section: Oxidative Stress (Os) As a Cause Of Female Fertility Impairm...mentioning

confidence: 99%

Oxidative Imbalance in Endometriosis-Related Infertility—The Therapeutic Role of Antioxidants

Dymanowska-Dyjak,

Frankowska,

Abramiuk

et al. 2024

IJMS

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Endometriosis in half of affected women is closely related to problems with fertility. Endometriosis-associated infertility is caused by a wide range of abnormalities affecting the female reproductive tract, from oocyte quality impairment to disturbances in the eutopic endometrium or mechanical abnormalities resulting from disease progression. Since supportive antioxidant therapies, in addition to surgical treatment or assisted reproductive techniques (ARTs), have overall been proven to be effective tools in endometriosis management, the objective of our review was to analyze the role of antioxidant substances, including vitamins, micronutrients, N-acetylcysteine (NAC), curcumin, melatonin, and resveratrol, in endometriosis-related infertility. Most of these substances have been proven to alleviate the systemic oxidant predominance, which has been expressed through decreased oxidative stress (OS) markers and enhanced antioxidative defense. In addition, we demonstrated that the predominant effect of the aforementioned substances is the inhibition of the development of endometriotic lesions as well as the suppression of pro-inflammatory molecules. Although we can undoubtedly conclude that antioxidants are beneficial in fertility support, further studies explaining the detailed pathways of their action are needed.

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Section: Oxidative Stress (Os) As a Cause Of Female Fertility Impairm...mentioning

confidence: 99%

Oxidative Imbalance in Endometriosis-Related Infertility—The Therapeutic Role of Antioxidants

Dymanowska-Dyjak,

Frankowska,

Abramiuk

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

Oxidative stress and female infertility: the role of follicular fluid soluble receptor of advanced glycation end-products (sRAGE) in women with endometriosis

Cited by 1 publication

References 44 publications

Oxidative Imbalance in Endometriosis-Related Infertility—The Therapeutic Role of Antioxidants

Oxidative Imbalance in Endometriosis-Related Infertility—The Therapeutic Role of Antioxidants

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