Elevated risk for squamous cell carcinoma of the conjunctiva among adults with AIDS in the United States

Guech-Ongey, Mercy; Engels, Eric A.; Goedert, James J.; Biggar, Robert J.; Mbulaiteye, Sam M.

doi:10.1186/1750-9378-4-s2-p21

Cited by 23 publications

(24 citation statements)

References 19 publications

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“…PLWHA also demonstrate an increased incidence of UV light-related cancers. A significant increased incidence of squamous cell carcinoma of the conjunctiva among PLWHA in the United States has been reported [26]. The relative proportion risk was highest with age greater than 50 years (8/100,000) and residence in a region with high solar ultraviolet radiation (10/100,000).…”

Section: Other Traditional Risk Factorsmentioning

confidence: 97%

Non–AIDS-Defining Malignancies in Patients with HIV in the HAART Era

Nguyen

Farrell

Gunthel

2010

Curr Infect Dis Rep

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The introduction of highly active antiretroviral therapy (HAART) has drastically changed the scope and spectrum of diseases associated with HIV, shifting from AIDS-related to non-AIDS-related diseases. Studies linking HIV/AIDS databases to cancer registries have shown a dramatic decrease in AIDS-related malignancies and a steady increase in non-AIDS-defining malignancies (NADM). We review the causes underlying the rise in incidence of NADM and the clinical presentation, pathology, and treatment outcomes of the four most commonly encountered NADM in the HAART era. Meta-analysis of published studies show an increase in NADM over the general population, mostly among infection-related cancers such as anal cancer, Hodgkin lymphoma, and liver cancer. Among the non-infection-related cancers, lung and skin cancers predominate. The overall effect of HAART on NADM is unsettled. As HIV-infected individuals survive longer, better screening strategies are needed to detect cancer earlier, and prospective data are needed to assess the impact of HAART on cancer outcomes.

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Section: Other Traditional Risk Factorsmentioning

confidence: 97%

Non–AIDS-Defining Malignancies in Patients with HIV in the HAART Era

Nguyen

Farrell

Gunthel

2010

Curr Infect Dis Rep

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“…Squamous cell cancer of the conjunctiva is a rare cancer that has been described as occurring at approximately 12-fold increased risk in people with AIDS in the US 84 , and also occurs at increased risk in kidney transplant recipients. 85 A marked increased in risk of this cancer has been described in African settings.…”

Section: Conjunctival Cancermentioning

confidence: 99%

The Epidemiology of Cancers in Human Immunodeficiency Virus Infection and After Organ Transplantation

Grulich

Vajdic

2015

Seminars in Oncology

105

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“…A recent analysis confirmed that risk of conjunctival SCC is also increased in adults with AIDS in the United States [45], and as for the transplanted population, sun exposure appeared to be a risk factor. Lifetime personal sun exposure data are required to confirm the role of sun exposure in the context of immune suppression for this and other neoplasms causally associated with exposure to UVR in the immune competent.…”

Section: Hodgkin Lymphoma and Non-hodgkin Lymphoma (Epstein-barr Virumentioning

confidence: 84%

What types of cancers are associated with immune suppression in HIV? Lessons from solid organ transplant recipients

Vajdic

Leeuwen

2009

Current Opinion in HIV and AIDS

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The similarity of the increased risk of cancer in these two immunosuppressed populations, who differ with respect to their underlying conditions and lifestyles, is compelling evidence that these cancers are associated with immune deficiency. The mechanisms are not fully understood but appear to be related to impaired immune surveillance. These data challenge the classification of only a narrow range of cancers as associated with immune suppression in people with HIV/AIDS.

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Elevated risk for squamous cell carcinoma of the conjunctiva among adults with AIDS in the United States

Cited by 23 publications

References 19 publications

Non–AIDS-Defining Malignancies in Patients with HIV in the HAART Era

Non–AIDS-Defining Malignancies in Patients with HIV in the HAART Era

The Epidemiology of Cancers in Human Immunodeficiency Virus Infection and After Organ Transplantation

What types of cancers are associated with immune suppression in HIV? Lessons from solid organ transplant recipients

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