Non–AIDS-Defining Malignancies in Patients with HIV in the HAART Era

Nguyen, Minh Ly; Farrell, Kevin; Gunthel, Clifford J.

doi:10.1007/s11908-009-0075-6

Cited by 41 publications

(33 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A correlation between the effectiveness of immune reconstitution following antiretroviral treatment, measured as CD4 ϩ T-lymphocyte counts, and the bifunctionality of total NK cells demonstrated that more effective control of HIV disease was associated with higher NK cell functionality. However, the lack of correlation between treatment efficacy and the NK cell education ratio is interesting, as it may provide a partial explanation for the higher incidence of non-AIDS-defining malignancies (NADMs) in HAART-treated HIV-infected individuals than in the general population (24). Future studies using larger sample sizes and following subjects over time will help elucidate the factors determining why some HIV-infected individuals exhibit normal NK cell education ratios and the potential role of these ratios in susceptibility to NADMs.…”

Section: Discussionmentioning

confidence: 99%

HIV Infection Abrogates the Functional Advantage of Natural Killer Cells Educated through KIR3DL1/HLA-Bw4 Interactions To Mediate Anti-HIV Antibody-Dependent Cellular Cytotoxicity

Parsons

Wren

Isitman

et al. 2012

J Virol

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

HIV Infection Abrogates the Functional Advantage of Natural Killer Cells Educated through KIR3DL1/HLA-Bw4 Interactions To Mediate Anti-HIV Antibody-Dependent Cellular Cytotoxicity

Parsons

Wren

Isitman

et al. 2012

J Virol

View full text Add to dashboard Cite

“…As a result, the incident of non-AIDSdefining-malignancy (NADM) has increased. Unfortunately, in these patients, such malignancies present at an earlier age and usually follow a more aggressive course (8,9). The exact reasons for this observation are unknown; however, many experts hypothesize that it may be partly due to the profound immune disarrangement produced by the HIV virus in their hosts (10).…”

Section: Introductionmentioning

confidence: 99%

Association between chronic hepatitis C and hepatitis C/HIV co-infection and the development of colorectal adenomas

Hurtado-Cordovi

Davis-Yadley

Lipka

et al. 2016

J. Gastrointest. Oncol.

View full text Add to dashboard Cite

Background: Limited knowledge exists about the effects chronic hepatitis C virus (HCV) infection has in the development of colorectal adenomas (CRA). Data regarding the association between chronic HIV infection and the development of CRA is scarce as well. We aim to determine if there is an association between the development of CRA and chronic infection with HCV and HCV/HIV co-infection.Methods: From July 1, 2009 to March 31, 2011 a total of 2,051 patients that underwent colonoscopy were included in our study. The population was divided into 2 study groups: those patients who tested positive for HCV, and HCV/HIC; the control groups consisted of patients whose results were negative. Fisher's exact χ 2 test for categorical variables and t-test for continuous variables was used to analyze data between groups.Logistic regression was performed to obtain odds ratios (OR).Results: CRA detection was higher in the HCV than in the control group (26.3% vs. 20.2%; P=1.02);Likewise, the incidence of CRA (25.5% vs. 20.8%; P=0.63) was higher in the co-infection group. However, in both of the study groups this difference was non-statistical.Conclusions: A higher detection rate of CRP was seen in the HCV population; however, it failed to reach statistical significance. Whether co-infection with HIV/HCV increases the incidence of CRA and/ or has a synergistic effect remains to be determined. The small sample population and the retrospective single institution nature of our study, as well as other confounders may have contributed to our negative results. However, our findings question whether HCV and HIV/HCV co-infected patients will benefit from screening colonoscopy at an earlier age. This issue merits further investigation with a large multi-center prospective study.

show abstract

“…This means that HIV-positive individuals live long enough to experience cancers that are more common in older individuals. A substantial amount of research is now being conducted on non-AIDS-defining malignancies in patients with HIV in the post-HAART era (Grulich et al, 2007;Nguyen et al, 2010;Shiels et al, 2011). The number of cancer sites wherein incidence is higher in HIV-positive individuals includes Hodgkin lymphoma, melanoma, leukaemia, and cancers of the liver, lung, anus, vagina, oropharynx, colon or rectum, and kidney.…”

Section: Human Immunodeficiency Virus and Cancersmentioning

confidence: 99%

Viral infections and human cancers: the legacy of Denis Burkitt

Harford

2012

Br J Haematol

View full text Add to dashboard Cite

SummaryDenis Parsons Burkitt was born in 1911, and in the late 1950s, described the disease that has come to be known as Burkitt lymphoma based on cases he observed in Uganda. Subsequently, Burkitt lymphoma was recognized as the first human tumour associated with an infectious agent when Epstein–Barr virus was isolated from samples supplied by Burkitt. It is now recognized that over one‐quarter of cancers worldwide are tied to infections. Notably, liver cancer is linked to hepatitis B virus and hepatitis C virus infections, and cervical cancer to infections involving the human papilloma viruses. In addition, immunocompromise arising from infection with the human immunodeficiency virus allows tumours (e.g., Kaposi sarcoma) caused by other viruses to arise. More than 50 years after the seminal paper by Burkitt based on his work in Africa, it is appreciated that the contribution of viral infections to cancers remains considerably higher in sub‐Saharan Africa than in the rest of the world.

show abstract

Non–AIDS-Defining Malignancies in Patients with HIV in the HAART Era

Cited by 41 publications

References 52 publications

HIV Infection Abrogates the Functional Advantage of Natural Killer Cells Educated through KIR3DL1/HLA-Bw4 Interactions To Mediate Anti-HIV Antibody-Dependent Cellular Cytotoxicity

HIV Infection Abrogates the Functional Advantage of Natural Killer Cells Educated through KIR3DL1/HLA-Bw4 Interactions To Mediate Anti-HIV Antibody-Dependent Cellular Cytotoxicity

Association between chronic hepatitis C and hepatitis C/HIV co-infection and the development of colorectal adenomas

Viral infections and human cancers: the legacy of Denis Burkitt

Contact Info

Product

Resources

About