Elevated resistin is related to inflammation and residual renal function in haemodialysed patients

Małyszko, Jolanta; Małyszko, J.; Kozminski, Piotr; Pawlak, Krystyna; Myśliwiec, Michał

doi:10.1111/j.1440-1797.2007.00782.x

Cited by 25 publications

(32 citation statements)

References 26 publications

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“…A previously published study (35) analyzing the serum resistin levels of adolescents with a mean age of 17.7 Ϯ 1.8 years found levels of 16.9 Ϯ 5.4 ng/ml in females and 14.0 Ϯ 7.2 ng/ml in males ( p Ͻ 0.02), whereas Malyszko et al measured similar resistin levels in men and women (25). Of note, in contrast to healthy subjects male HD patients had significantly higher serum resistin levels than female patients (Table I).…”

Section: Discussionmentioning

confidence: 91%

“…In rodents, adipose tissue is the main source of resistin and is considered as a link between obesity and diabetes by impairing insulin sensitivity and glucose tolerance (16). In humans, however, resistin is expressed primarily in macrophages (17) and represents a potential novel link between inflammation and adipocytokines (25). Its role in human insulin resistance remains controversial.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, resistin is a potential uremic toxin contributing to the disturbed immune response in uremic patients by affecting functional abilities of PMNLs, cells which play a key role in the nonspecific immune defense against bacterial infections. Increased serum resistin concentrations in HD patients may be a result of CKD and/or inflammation (25), considering that human resistin is primarily expressed by inflammatory cells and that resistin levels are positively associated with levels of inflammatory markers (32)(33)(34).…”

Section: Discussionmentioning

confidence: 99%

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Resistin Inhibits Essential Functions of Polymorphonuclear Leukocytes

Cohen

Ilić

Raupachova

et al. 2008

The Journal of Immunology

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The serum levels of resistin, a 12-kDa protein primarily expressed in inflammatory cells in humans, are increased in patients with chronic kidney disease and in those with diabetes mellitus. Both groups of patients have an increased risk of infections mainly as a result of disturbed polymorphonuclear leukocyte (PMNL) functions. Therefore, we investigated the influence of resistin on human PMNLs. Serum resistin concentrations were determined with a sandwich enzyme immunoassay. Using PMNLs from healthy subjects, chemotaxis was tested by the under-agarose method. Flow cytometric assays to measure oxidative burst and phagocytosis were conducted in whole blood. The uptake of deoxyglucose was determined as measure of the PMNL activation state. The activity of intracellular kinases was assessed by Western blotting and by in vitro kinase assays. Resistin inhibited PMNL chemotaxis and decreased the oxidative burst stimulated by Escherichia coli and by PMA, but did not influence PMNL phagocytosis of opsonized E. coli and PMNL glucose uptake. The inhibition of PMNLs by resistin was observed at concentrations found in serum samples of uremic patients, but not in concentrations measured in healthy subjects. Experiments with specific signal transduction inhibitors and measurements of intracellular kinases suggest that PI3K is a major target of resistin. In conclusion, resistin interferes with the chemotactic movement and the stimulation of the oxidative burst of PMNL, and therefore may contribute to the disturbed immune response in patients with increased resistin serum levels such as uremic and diabetic subjects.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Resistin Inhibits Essential Functions of Polymorphonuclear Leukocytes

Cohen

Ilić

Raupachova

et al. 2008

The Journal of Immunology

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“…Adipose tissue is thought to be involved in energy regulation, inflammation, and the immune response, and adipocytes have been shown to be a part of the hematopoietic microenvironment. Malyszko et al reported an association between resistin and inflammatory markers in HD patients (Malyszko et al 2007). Resistin in humans is primarily produced by inflammatory cells, both inside and outside the adipose tissue (Steppan et al 2001;Patel et al 2003).…”

Section: Discussionmentioning

confidence: 99%

Serum Resistin as a Novel Marker of Erythropoietin Resistance in Nondiabetic Patients on Hemodialysis

Chang

Jung

Lee

et al. 2011

Tohoku J. Exp. Med.

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The use of higher erythropoietin (EPO) doses is associated with an increased risk of an adverse outcome and increased mortality in patients with renal failure. Resistin is related to heart disease, and may contribute to an increased atherosclerotic risk. We hypothesized that a link between resistin and EPO responsiveness may exist. We therefore investigated the relationship between resistin and the EPO resistance index (ERI) in nondiabetic hemodialysis (HD) patients. Fifty-seven patients enrolled in the study underwent HD for ≥ 3 months and intravenous EPO therapy to maintain a target hemoglobin (Hb) level of 11.0 g/dl. The ERI was defined as the weekly EPO dose per unit Hb per body weight. The mean patient age was 52.6 ± 11.9 years and the mean time on dialysis was 4.9 ± 4.4 years. Serum Hb and ERI were 10.4 ± 0.7 g/dl, and 13.3 ± 7.0 (IU/kg/week/g/dl), respectively. Serum resistin levels were 23.6 ± 9.3 µg/L. EPO resistance is associated with low body mass index (BMI) (coefficient β =−0.393, p = 0.002) and with high serum resistin levels (coefficient β = 0.332, p = 0.018). According to a multiple regression analysis, the serum resistin level was a significant independent factor related to EPO resistance (p = 0.017). The results suggest that serum resistin levels reflect EPO responsiveness in nondiabetic HD patients. Resistin may therefore be considered as a new marker of EPO responsiveness in HD patients.

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“…Axelsson et al [30] examined the role of resistin in 239 individuals with CKD and found strong associations of resistin with GFR and inflammatory markers. Malyszko et al [29] demonstrated that patients on hemodialysis with residual kidney function have significantly lower resistin levels than those without residual renal function, supporting the hypothesis that resistin is excreted via the kidney. To the best of our knowledge, only one study has assessed these associations in kidney transplant recipients [18].…”

Section: Discussionmentioning

confidence: 95%

Association between serum resistin level and outcomes in kidney transplant recipients

Nagy

Újszászi

Czira³

et al. 2016

Transpl Int

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SummaryResistin is an adipocytokine that is associated with inflammation, coronary artery disease, and other types of cardiovascular disease among patients with normal kidney function. However, little is known about the association of resistin with outcomes in kidney transplant recipients. We collected socio-demographic and clinical parameters, medical and transplant history, and laboratory data from 988 prevalent kidney transplant recipients enrolled in the Malnutrition-Inflammation in Transplant-Hungary Study (MINIT-HU study). Serum resistin levels were measured at baseline. Associations between serum resistin level and death with a functioning graft over a 6-year follow-up period were examined in unadjusted and adjusted models. The meanAESD age of the study population was 51 AE 13 years, among whom 57% were men and 21% were diabetics. Median serum resistin concentrations were significantly higher in patients who died with a functioning graft as compared to those who did not die during the follow-up period (median ng/ml, respectively; P < 0.001). Higher serum resistin level was associated with higher mortality risk in both unadjusted and fully adjusted models: HRs (95% CI): 1.33(1.16-1.54) and 1.21 (1.01-1.46), respectively. In prevalent kidney transplant recipients, serum resistin was an independent predictor of death with a functioning graft.

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Elevated resistin is related to inflammation and residual renal function in haemodialysed patients

Abstract: Elevated resistin related to markers of inflammation may represent a novel link between inflammation and adipocytokines in HD patients. Impaired renal function and inflammation are responsible for elevated resistin in HD patients.

Cited by 25 publications

References 26 publications

Resistin Inhibits Essential Functions of Polymorphonuclear Leukocytes

Resistin Inhibits Essential Functions of Polymorphonuclear Leukocytes

Serum Resistin as a Novel Marker of Erythropoietin Resistance in Nondiabetic Patients on Hemodialysis

Association between serum resistin level and outcomes in kidney transplant recipients

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