Association between serum resistin level and outcomes in kidney transplant recipients

Abstract

SummaryResistin is an adipocytokine that is associated with inflammation, coronary artery disease, and other types of cardiovascular disease among patients with normal kidney function. However, little is known about the association of resistin with outcomes in kidney transplant recipients. We collected socio-demographic and clinical parameters, medical and transplant history, and laboratory data from 988 prevalent kidney transplant recipients enrolled in the Malnutrition-Inflammation in Transplant-Hungary Study (MINIT-HU study). Serum resistin levels were measured at baseline. Associations between serum resistin level and death with a functioning graft over a 6-year follow-up period were examined in unadjusted and adjusted models. The meanAESD age of the study population was 51 AE 13 years, among whom 57% were men and 21% were diabetics. Median serum resistin concentrations were significantly higher in patients who died with a functioning graft as compared to those who did not die during the follow-up period (median ng/ml, respectively; P < 0.001). Higher serum resistin level was associated with higher mortality risk in both unadjusted and fully adjusted models: HRs (95% CI): 1.33(1.16-1.54) and 1.21 (1.01-1.46), respectively. In prevalent kidney transplant recipients, serum resistin was an independent predictor of death with a functioning graft.

Adipocytokines in renal transplant recipients

“…In contrast, Chung et al [ 212 ] found that lower serum resistin concentrations were associated with lower survival rates in patients on hemodialysis. Our results also suggest that higher resistin levels have a dose-dependent relationship with risk of graft loss and mortality even after multivariable adjustment in KTRs [ 213 ]. We found that for every 10 ng/mL elevation of serum resistin level there is a 30% increased mortality risk and 73% increased risk of graft loss [ 213 ].…”

A prediction model of contrast-associated acute kidney injury in patients with hypoalbuminemia undergoing coronary angiography

“…Hydration has been considered an effective treatment for CA-AKI, but the actual effect of this strategy is still controversial. Perioperative hydration can expand plasma volume by inhibiting the renin-angiotensin-aldosterone system, reducing the concentration of contrast media in the tubule lumen and vasa recta, and counteraction of medullary vasoconstriction activation [40].. It is still the cornerstone of CA-AKI prevention.…”

A prediction model of Contrast-associated Acute Kidney Injury in Patients with Hypoalbuminemia Undergoing Coronary Angiography

“…A recent review concluded that diabetes is not independently associated with the risk of developing CA-AKI and only increases susceptibility in patients with underlying kidney disease [34]. Regarding contrast volume, current studies suggested that the development of AKI after contrast exposure is signi cantly determined by the presence of comorbidities and hemodynamic instability rather than contrast volume [35,36]. Besides, Mehran et al conducted a recent review and adapted the concept of contrast-associated AKI instead of contrast-induced AKI [1].…”