Elevated Red Cell Distribution Width is Associated with Cerebral Infarction in Aneurysmal Subarachnoid Hemorrhage

Siegler, James E.; Marcaccio, Christy; Nawalinski, Kelsey; Quattrone, Francis; Sandsmark, Danielle K.; Maloney-Wilensky, Eileen; Frangos, Suzanne; Levine, Joshua M.; Stein, Sherman C.; Kasner, Scott E.; Kumar, Monisha A.

doi:10.1007/s12028-016-0306-2

Cited by 32 publications

(32 citation statements)

References 38 publications

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“…42 Siegler et al undertook a retrospectively investigated of RDW in 179 patients with aneurysmal subarachnoid hemorrhage (aSAH) admitted to a neurointensive care unit and found that there is a significant association between elevated RDW level and incidence of cerebral infarction and adverse clinical outcomes after aSAH. 43 Kaya et al showed that in i53 patients with HF who had had a stroke there was a significantly increased baseline RDW in comparison with patients without stroke, suggesting that RDW may be a predictive marker for the incidence of stroke in HF patients. A RDW >15.2% at the time of admission had 87% sensitivity and 74% specificity for stroke incidence in HF patients.…”

Section: Prognostic Role Of Rdw In Ischemic Cerebrovascular Diseasementioning

confidence: 99%

The diagnostic and prognostic value of red cell distribution width in cardiovascular disease; current status and prospective

et al. 2019

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The red blood cell distribution width (RDW) is an index of the heterogeneity of circulating red blood cell size, which along with other standard complete blood count (CBC) parameters are used to identify hematological system diseases. Besides hematological disorders, several clinical studies have shown that an increased in the RDW may be associated with other diseases including acute pancreatitis, chronic kidney disease, gastrointestinal disorders, cancer, and of special interest in this review, cardiovascular disease (CVD). The diagnostic and prognostic value of RDW in different CVD (acute coronary syndrome, ischemic cerebrovascular disease, peripheral artery disease, atrial fibrillation, heart failure, and acute ischemic stroke) has been reviewed in this article, to provide an understanding how its measurement may be applied to improve the management of these conditions.

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Section: Prognostic Role Of Rdw In Ischemic Cerebrovascular Diseasementioning

confidence: 99%

The diagnostic and prognostic value of red cell distribution width in cardiovascular disease; current status and prospective

et al. 2019

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“…An increased RDW has a high negative predictive value for diagnosing various disorders, and also conveys important information for short-and long-term prognoses. RDW is associated with a variety of cerebrovascular diseases and prognosis, such as stoke [12], cerebral infarction [13] and cerebral thrombosis [14], indicating that RDW may be involved in the cerebral hemodynamic changes. The cerebral blood flow in normal subjects is constant under different contexts and is decided by the cardiac output and the regulatory mechanism.…”

Section: Introductionmentioning

confidence: 99%

Preoperative red cell distribution width predicts postoperative cognitive dysfunction after coronary artery bypass grafting

Wan

Luo

et al. 2020

Bioscience Reports

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We assessed the relationship between red blodd cell distribution width (RDW) and postoperative cognitive dysfunction (POCD) after coronary artery bypass grafting (CABG) in patients who usually had obvious hemodynamic changes. We enrolled 362 coronary heart disease patients who received CABG. POCD was assessed through neuropsychological examination at 21 days after operation. Demographics, history of diseases, blood biochemical parameters and perioperative data were collected. The receiver operating characteristic (ROC) curve was used to find the best cut-off value of RDW for diagnosis of POCD. Logistic regression was used to explore the relationship between RDW and POCD. The 21-day incidence of POCD in patients receiving CABG was 27.1% (98/362). The RDW of POCD patients was significantly higher than in the non-POCD patients (17.4 vs. 13.2). The sensitivity and specificity of RDW for predicting POCD were 82.7 and 64.8%, respectively. The POCD patients also tended to be older and had higher fasting plasma glucose, hypersensitive c-reactive protein, tumor necrosis factor-α, white blood cell levels and longer surgery time. No significant differences were found in other parameters. The 21-day neuropsychological test results were better in the POCD patients than the non-POCD patients. After adjustment of potential factors, the preoperative high RDW was still associated with an increased risk of POCD (odds ratio (OR) = 2.52, 95% confidence interval (CI): 1.28–4.31). Our study indicates that preoperative RDW is significantly elevated in POCD patients receiving CABG. The elevated preoperative RDW is associated with an increased risk of POCD and preoperative RDW can be an independent predictor of POCD.

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“…Recent studies have shown that RDW played a key role in cardiovascular disease progression through various physiological and pathological manifestations [ 1 – 3 ]. Increased attention has been focused on the predictive and prognostic value of RDW in patients with coronary heart disease, heart failure, atrial fibrillation, aortic valve replacement surgery, acute pulmonary embolism and cerebral infarction [ 4 – 10 ]. Elevated RDW is associated with a higher risk of perioperative stroke/transient ischaemic attack and death in patients undergoing heart valve surgery [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Combined value of red blood cell distribution width and global registry of acute coronary events risk score on predicting long-term major adverse cardiac events in STEMI patients undergoing primary PCI

et al. 2018

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The combined value of RDW and GRACE risk score for cardiovascular prognosis in ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI) has not been fully investigated. This study was designed to explore the combined value of RDW and GRACE risk score on predicting long-term major adverse cardiac event (Mace) in STEMI patients undergoing primary PCI. This study included 390 STEMI patients. The primary endpoint at the (33.5 ± 7.1) months follow-up was composed of cardiac death and nonfatal myocardial infarction. The relationship between clinical parameters and clinical outcomes was evaluated using Cox regression model and receiver operating characteristic (ROC) analysis. Mace occurred in 126 (32.3%) patients including 54 (13.8%) cardiac deaths and 72 (18.5%) nonfatal myocardial infarctions. Patients in Mace group had significantly higher RDW and GRACE score than the patients in non-Mace group. According to the Cox model, RDW and GRACE score were the most important independent predictors of Mace and cardiac death. The best cut-off value for RDW to predict the occurrence of primary events was 13.25% (AUC = 0.694, 95% CI:0.639–0.750, P < 0.001) and that for GRACE score was 119.5 (AUC = 0.721, 95% CI:0.666–0.777, P < 0.001). The combination of RDW and GRACE score were more valuable (AUC = 0.775, 95% CI: 0.727–0.824, P < 0.001). Kaplan–Meier analysis provided significant prognostic information with the highest risk for cardiac death (Log-Rank χ2 = 24.684, P < 0.001) in group with both high RDW (> 13.25%) and high GRACE score (> 119.5). The combination of RDW level and GRACE score may be valuable and simple independent predictors of Mace and cardiac death in STEMI patients undergoing primary PCI. They may be useful tools for risk stratification and may indicate long-term clinical outcomes.

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Elevated Red Cell Distribution Width is Associated with Cerebral Infarction in Aneurysmal Subarachnoid Hemorrhage

Abstract: RDW elevation is associated with cerebral infarction and poor outcome after aSAH. Further evaluation of this association is warranted as it may shed light on mechanistic relations between anemia, inflammation, and thrombosis after aSAH.

Cited by 32 publications

References 38 publications

The diagnostic and prognostic value of red cell distribution width in cardiovascular disease; current status and prospective

The diagnostic and prognostic value of red cell distribution width in cardiovascular disease; current status and prospective

Preoperative red cell distribution width predicts postoperative cognitive dysfunction after coronary artery bypass grafting

Combined value of red blood cell distribution width and global registry of acute coronary events risk score on predicting long-term major adverse cardiac events in STEMI patients undergoing primary PCI

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