Elevated preoperative platelet-to-lymphocyte ratio predicts poor prognosis of patients with primary gastrointestinal stromal tumor

Chang, Weilong; Yang, Wenchang; Zeng, Xiangyu; Li, Chengguo; Zhou, Xiong; Wang, Tao; Zhang, Ruizhi; Tao, Kaixiong; Zhang, Peng

doi:10.1186/s12876-020-01275-2

Cited by 10 publications

(7 citation statements)

References 29 publications

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“…Several studies have been performed to evaluate the impact of COVID-19 on the gut microbiome. The first study on 15 patients demonstrated a gut microbiome fingerprint characterized by a decrease of the beneficial commensals and increase of opportunistic pathogen [ 245 ]. This dysbiosis was associated with the severity of the disease.…”

Section: Covid 19: Relevance Of Host Genetic Factorsmentioning

confidence: 99%

Host factors facilitating SARS‐CoV‐2 virus infection and replication in the lungs

Boutin

Hildebrand

Boulant

et al. 2021

Cell. Mol. Life Sci.

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SARS-CoV-2 is the virus causing the major pandemic facing the world today. Although, SARS-CoV-2 primarily causes lung infection, a variety of symptoms have proven a systemic impact on the body. SARS-CoV-2 has spread in the community quickly infecting humans from all age, ethnicities and gender. However, fatal outcomes have been linked to specific host factors and co-morbidities such as age, hypertension, immuno-deficiencies, chronic lung diseases or metabolic disorders. A major shift in the microbiome of patients suffering of the coronavirus disease 2019 (COVID-19) have also been observed and is linked to a worst outcome of the disease. As many co-morbidities are already known to be associated with a dysbiosis of the microbiome such as hypertension, diabetes and metabolic disorders. Host factors and microbiome changes are believed to be involved as a network in the acquisition of the infection and the development of the diseases. We will review in detail in this manuscript, the immune response toward SARS-CoV-2 infection as well as the host factors involved in the facilitation and worsening of the infection. We will also address the impact of COVID-19 on the host’s microbiome and secondary infection which also worsen the disease.

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Section: Covid 19: Relevance Of Host Genetic Factorsmentioning

confidence: 99%

Host factors facilitating SARS‐CoV‐2 virus infection and replication in the lungs

Boutin

Hildebrand

Boulant

et al. 2021

Cell. Mol. Life Sci.

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“…In addition, a series of studies have reported that many inflammation-based markers were directly related to poor prognosis or post-operative complications in patients with hip fracture, including prognostic nutritional index ratio (PNI) [ 9 ], CRP/PNI ratio [ 10 ], and neutrophil-to-lymphocyte ratio (NLR) [ 11 , 12 ]. Platelet-to-lymphocyte ratio (PLR), a novel marker of systemic inflammation, has been reported to be closely related to the prognosis of many diseases, such as inflammatory diseases [ 13 ], cardiovascular disease [ 14 ], and various malignancies [ 15 – 17 ], even in the 2019-novel coronavirus disease (COVID-19) [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

High platelet-to-lymphocyte ratio predicts poor survival of elderly patients with hip fracture

Wang¹,

Wang²,

Yang³

et al. 2020

International Orthopaedics (SICOT)

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Purpose The platelet-to-lymphocyte ratio (PLR) has been extensively studied in various diseases. However, the relationship between PLR and hip fracture remains unknown. The aim of this study was to evaluate whether PLR would be an independent prognostic factor in elderly hip fracture patients. Methods Between January 2014 and December 2018, a retrospective cohort study was conducted in a orthopaedic centre, China. A total of 460 hip fracture patients were included. PLR was calculated as the ratio of platelet to lymphocyte counts and divided into high PLR group (≥ 189) and low PLR group (< 189) by using the receiver operating characteristic (ROC) curve. The relationship between PLR and one year all-cause mortality rate was assessed by univariate and multivariate Cox proportional hazard models. Further subgroup analysis stratified by different clinical and biological characteristics was performed to make the results more accurate. Results After a median follow-up of 32.0 months (range, 12.0-75.4), 92 patients (mortality rate: 20.0%) died within one year. PLR was significantly higher in dead patients compared with alive patients (p < 0.05), and high PLR group also had a high mortality rate (32.21% vs. 14.15%, p < 0.001). After multivariate adjustment, high PLR remained an independent predictor for one year all-cause mortality (adjusted hazard ratio (HR) 1.56, 95% confidence interval (CI) 1.02-2.41, p = 0.041). Moreover, advanced age (HR 1.05, 95% CI 1.01-1.08), male (HR 1.62, 95% CI 1.06-2.45), CCI ≥ 2 (HR 2.83, 95% CI 1.64-4.89), conservative treatment (HR 5.94, 95% CI 3.71-9.73), low haemoglobin level (HR 1.02, 95% CI 1.01-1.04), and low albumin level (HR 1.07, 95% CI 1.02-1.13) were independent risk factors for survival. Furthermore, subgroup analysis results were consistent with the main findings in most stratified groups. Conclusion This study highlights that high PLR (≥ 189) is associated with increased one year all-cause mortality in elderly hip fracture patients. As PLR is a simple indicator that can be calculated from the blood routine test, it can be easily performed in usual clinical practice.

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“…Previous evidence has demonstrated that high neutrophil‐to‐lymphocyte ratio (NLR) or platelet‐to‐lymphocyte ratio (PLR) levels were associated with worse prognosis in patients with surgically resected GISTs. However, the role of these markers still lacks sufficient evidence and remains controversial 9,10 . This suggests us that nutritional status could be a potential prognostic predictor for GIST patients.…”

Section: Introductionmentioning

confidence: 99%

Controlling Nutritional Status (CONUT) score as a prognostic marker for gastrointestinal stromal tumours

Sui,

Lin,

Tao

et al. 2023

ANZ Journal of Surgery

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BackgroundThe Controlling Nutritional Status (CONUT) score, regarded as the effective indicator of patient nutrition, has been demonstrated to be related to prognosis of numerous tumours. Nevertheless, the significance of CONUT for gastrointestinal stromal tumour (GIST) remains unclear. This study intended to clarify the association between CONUT and the prognosis of GISTs.MethodsThree hundred and fifty‐five patients with GISTs undergoing surgical resection at our center were retrospectively assessed. Receiver operating characteristic curve analysis was used to help determine the cut‐off value of CONUT score. Relapse‐free survival (RFS) and overall survival (OS) were assessed by Kaplan–Meier curve analysis. Prognostic factors for RFS and OS were examined by Cox proportional hazards models.ResultsA total of 355 patients were enrolled in this study. Areas under the curve (AUC) were 0.638 for CONUT score, and the cut‐off value of CONUT was shown to be three. Kaplan–Meier curve analysis showed that high CONUT score was linked to poorer RFS and OS. Univariate and multivariate analyses ultimately revealed that CONUT was a risk factor for RFS and OS, independent of demographics and clinicopathological tumour characteristics.ConclusionsCONUT score was an effective and novel predictor for prognosis of GIST patients treated with surgery, indicating its potential as a prognostic marker in the overall management.

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Elevated preoperative platelet-to-lymphocyte ratio predicts poor prognosis of patients with primary gastrointestinal stromal tumor

Cited by 10 publications

References 29 publications

Host factors facilitating SARS‐CoV‐2 virus infection and replication in the lungs

Host factors facilitating SARS‐CoV‐2 virus infection and replication in the lungs

High platelet-to-lymphocyte ratio predicts poor survival of elderly patients with hip fracture

Controlling Nutritional Status (CONUT) score as a prognostic marker for gastrointestinal stromal tumours

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