Elevated Preoperative Platelet to Lymphocyte Ratio Associated with Decreased Survival of Women with Ovarian Clear Cell Carcinoma

Abstract

This study was conducted to establish whether the preoperative platelet to lymphocyte ratio (PLR) is predictive of survival of women with ovarian clear cell carcinoma (OCCC). A PLR > 300 was deemed elevated. Progression-free survival (PFS) was estimated using the Kaplan-Meier method. Cox proportional hazard analysis was used to determine the independent effect of PLR. Thirty-six patients were reviewed. Elevated PLRs were more commonly noted in patients with an advanced vs an early stage of disease (88.9% vs 11.1%). Women with elevated PLR carried a higher rate of disease progression during primary therapy than that those in the normal PLR group (44.4 vs 22.2%). The median PFS for patients with elevated PLR was notably worse than that for patients with normal PLR (10 vs 34 months). Despite the impact of elevated PLR on PFS, it was found to be marginally significant when controlling for commonly applied prognostic markers. It, however, trended toward significance (HR=4.76; 95%CI, 0.95-23.8). In conclusion, an elevated PLR appears to be directly associated with adverse survival rather than being a surrogate for other indicators of a poor prognosis. PLR may be a useful biomarker for predicting survival of women with OCCC and merits further large-scale studies.

Prognostic significance of platelet‐to‐lymphocyte ratio in patients with ovarian cancer: A meta‐analysis

“…As a result, 11 eligible studies, comprising a total of 3574 patients, were included in the quantitative synthesis. [17][18][19][24][25][26][27][28][29][30][31] The selection process is shown in Figure 1.…”

Association between hematologic parameters and in‐hospital mortality in patients with infective endocarditis

“…Moreover, the test does not require any complex or expensive technologies [13,14]. Recently, PLR was used as a worse prognostic marker of various cardiovascular conditions [15–18]. However, there are no data regarding its predictive role in patients with IE.…”

1868 Prognostic Value of Preoperative Lymphocyte-Monocyte Ratio in Patients with Ovarian Clear Cell Carcinoma

“…In addition, LMR was found to predict the outcome of primary surgical cytoreduction in EOC patients, and LMR, age, CA125 level, and WBC count were found to be reliable predictors of suboptimal cytoreduction [20]. Although the prognostic value of SIR has been established in EOC, its value in OCCC has not been well studied [21][22][23], and few studies have compared the prognostic values of SIR, NLR, and PLR in OCCC, but the prognostic value of LMR has yet to be evaluated in OCCC.…”

“…NLR and PLR have been shown to be independent prognostic markers of adverse clinical outcomes in EOC [8,24,25] and specifically in OCCC [21][22][23]. In EOC, NLR known to be strongly associated with poor clinicopathological features, a high tumor burden, stage, preoperative CA125 level, and ascites at surgery in EOC [24].…”

“…The strength of our study is that it represents a first attempt to evaluate the prognostic value of LMR in OCCC. Recent studies on SIR markers in OCCC did not include LMR as a potential prognostic marker [21][22][23]. OCCC has been well demonstrated to be associated with chronic inflammation.…”