Elevated preoperative plasma D-dimer dose not adversely affect survival of gastric cancer after gastrectomy with curative intent: A propensity score analysis

Liang, Yuexiang; He, Dalin; Wu, Liangliang; Ding, Xiaobo; Wang, Xiaona; Wang, Baogui; Zhang, Rupeng; Liang, Han

doi:10.21147/j.issn.1000-9604.2018.02.08

Cited by 5 publications

(3 citation statements)

References 25 publications

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“…Long Liu et al reported that high D-dimer level may predict poor outcome of GC patients 14 . Controversially, Yuexiang Liang et al illuminated that preoperative D-dimer was not an independent prognostic factor for patients with GC after curative resection 18 . Although the difference in research results may be due to regional differences in distribution and the influence of confounding factors, it is significant to explore the prognostic value of D-dimer in GC.…”

Section: Discussionmentioning

confidence: 99%

“…Consistently, our previous research showed that D-dimer is not only an indicator of venous thrombosis but also a marker for predicting cancer progression in GC patients 17 . In contrast, Liang et al reported that elevated preoperative D-dimer was not an independent prognostic factor for GC based on propensity score matching analysis 18 . Based on this controversy, the aim of our study was to explore the correlation between preoperative D-dimer and long-term survival of GC patients after curative surgery.…”

Section: Introductionmentioning

confidence: 95%

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D-dimer, a predictor of bad outcome in gastric cancer patients undergoing radical resection

Zhang

Wang

et al. 2022

Sci Rep

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As a marker of hypercoagulability, plasma D-dimer is associated with progression of many cancers but remains controversial in gastric cancer (GC). We aim to investigate the predictive value of D-dimer for postoperative outcomes after radical gastrectomy of GC patients. We enrolled 903 consecutive patients with GC who underwent radical gastrectomy and the clinicopathological characteristics were compared. Risk factors for overall survival (OS) and disease-free survival (DFS) were determined using multivariate cox regression analysis. We also compared the survival difference based on Kaplan–Meier method after a one-to-one propensity score matching (PSM). Patients with elevated D-dimer had older age (p < 0.001), advanced TNM stage (p < 0.001), larger tumor size (p = 0.005), lower 5-year OS rate (32.8% vs 62.6%, p < 0.001) and DFS (29% vs 59.6%, p < 0.001). In multivariate analysis, elevated D-dimer was independently associated with shorter OS [hazard ratio (HR): 1.633, 95% confidence interval (CI) 1.178–2.264, p = 0.003] and DFS (HR: 1.58, 95% CI 1.151–2.169, P = 0.005). After PSM, the 5-year OS rate of patients with elevated D-dimer was still significantly lower than matched group (32.8% vs 40.6%, p = 0.005), so was DFS (29% vs 36.6%, p = 0.008). Preoperative elevated D-dimer is an independent risk factor for GC patients undergoing curative gastrectomy.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

D-dimer, a predictor of bad outcome in gastric cancer patients undergoing radical resection

Zhang

Wang

et al. 2022

Sci Rep

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“…D-dimer is one of the terminal fibrin decomposition products, which can affect cellular signaling systems, promote cell proliferation, stimulate cellular adhesion of tumor cells to endothelial cells and affect platelets and extra-cellular matrix, inducing the growth and spread of tumors 4. In a study of 41 gastric cancer patients, Dian analyzed the plasma D-dimer levels and circulating tumor cells, concluded that D-dimer was an essential accompaniment of circulating tumor cells in gastric cancer, which can be used in the detection of hematogenous metastasis 5.…”

Section: Introductionmentioning

confidence: 99%

Analysis of the expression of D-dimer, CD147 and miR203 and their correlation in gastric cancer

Wu¹,

Liu²

2019

Pak J Med Sci

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Objectives: To evaluate the relationship of D-dimer, CD147 and miR-203, and detect the influence of these biomarkers on the pathological characteristics in patients with gastric cancer. Methods: The patients with gastric cancer treated using radical gastrectomy between May 2013 and October 2017 were reviewed retrospectively. The expression of D-dimer, miR203 and CD147 was measured for all the patients, and the clinical data including age, gender, tumor size, tumor differentiation, invasion depth, lymphatic metastasis, TMN stage, and pathological type were retrieved and analyzed. The study was carried out in affiliated Yidu Central Hospital of Weifang Medical College, Qingzhou, China. Results: Two hundred sixty patients with gastric cancer were included. The patients with tumor metastasis, larger tumor diameter, lower differentiation, lymphatic metastasis, deeper invasion, and higher TMN stage presented with a significantly higher D-dimer and CD 147 expression, but the level of the two biomarkers didn’t show a significant difference in patients with different pathological type, gender and age. Compared with CD147 and D-dimer, miR203 presented with different characteristics of expression. In addition, the expression of miR203 was negatively correlated with CD147 and D-dimer, and there was a positive correlation between CD147 and D-dimer in patients with gastric cancer. Conclusion: In this study, a close correlation of D-dimer, miR203 and CD147 was found, and these three biomarkers should be screened in gastric cancer patients. How to cite this:Wu X, Liu X. Analysis of the expression of D-dimer, CD147 and miR203 and their correlation in gastric cancer. Pak J Med Sci. 2019;35(2):---------. doi: https://doi.org/10.12669/pjms.35.2.718 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Prognostic value of D-dimer levels in patients with gastric cancer undergoing gastrectomy

Kim

Song

2021

Surgical Oncology

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Elevated preoperative plasma D-dimer dose not adversely affect survival of gastric cancer after gastrectomy with curative intent: A propensity score analysis

Abstract: The poor prognosis of GC patients with elevated preoperative PDL was due to the advanced tumor stage and elder age rather than the elevated D-dimer itself.

Cited by 5 publications

References 25 publications

D-dimer, a predictor of bad outcome in gastric cancer patients undergoing radical resection

D-dimer, a predictor of bad outcome in gastric cancer patients undergoing radical resection

Analysis of the expression of D-dimer, CD147 and miR203 and their correlation in gastric cancer

Prognostic value of D-dimer levels in patients with gastric cancer undergoing gastrectomy

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