Elevated preoperative neutrophil to lymphocyte ratio predicts risk of recurrence following curative resection for stage IIA colon cancer

Ding, Pei Rong; An, Xin; Zhang, Rong Xin; Yu, Fang; Li, Li Ren; Chen, Gong; Wu, Xiao; Lü, Zhen; Lin, Jun; Kong, Ling Heng; Wan, De Sen; Pan, Zhi Zhong

doi:10.1007/s00384-010-1052-0

Cited by 199 publications

(182 citation statements)

References 29 publications

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“…Recent studies have reported the prognostic significance of the preoperative inflammation-based scores, such as the GPS, the neutrophil to lymphocyte ratio (23), the platelet to lymphocyte ratio (24), the Prognostic index (25), and the Prognostic nutritional index (26). An inflammatory response to the tumor leads to tumor proliferation and metastasis due to inhibition of apoptosis and promotion of angiogenesis (27)(28)(29)(30).…”

Section: Discussionmentioning

confidence: 99%

Glasgow prognostic score predicts therapeutic outcome after hepatic resection for hepatocellular carcinoma

Shiba¹,

Horiuchi²,

Sakamoto³

et al. 2017

Oncology Letters

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Abstract. Systemic inflammation, as evidenced by the Glasgow prognostic score (GPS), predicts cancer-specific survival in various cancer types. The aim of this study was to evaluate the significance of the GPS in the therapeutic outcome of the patient following surgical resection for hepatocellular carcinoma. In total, 144 patients underwent surgical resection for hepatocellular carcinoma. For the assessment of systemic inflammatory response using the GPS, patients were classified into three groups: Patients with normal serum albumin (<3.5 g/dl) and normal serum C-reactive protein (CRP) (≤1.0 mg/dl) were classified as GPS 0 (n=76), those with low serum albumin (<3.5 g/dl) or elevated serum CRP (>1.0 mg/dl) were classified as GPS 1 (n=58), and those with low serum albumin (<3.5 g/dl) and elevated serum CRP (>1.0 mg/dl) were classified as GPS 2 (n=10). Retrospectively, the relationship between patient characteristics including GPS, disease-free as well as overall survival were investigated. In disease-free survival, GPS 2 (P=0.019), with a tumor number ≥3 (P=0.004), and positive portal or venous invasion (P= 0.034) were independent predictors of cancer recurrence in multivariate analysis. In overall survival, GPS 1 (P= 0.042), GPS 2 (P<0.001) and positive portal or venous invasion (P<0.001) were independent predictors of poor patient outcome according to multivariate analysis. To conclude, the GPS in patients with hepatocellular carcinoma is an independent prognostic predictor after hepatic resection.

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Section: Discussionmentioning

confidence: 99%

Glasgow prognostic score predicts therapeutic outcome after hepatic resection for hepatocellular carcinoma

Shiba¹,

Horiuchi²,

Sakamoto³

et al. 2017

Oncology Letters

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“…On the other hand some reports have studied different stages like we did, while others analyzed specific stage of patients in terms of survival analysis. Ding et al (2010) studied only stage IIA patient; on the contrary Walsh et al (2005) studied all Dukes stages patients. Additionally, Halazun et al (2008) found that elevated NLR increases both risk of death and the risk of recurrence in patients who undergo surgery for CRC liver metastases.…”

Section: Discussionmentioning

confidence: 99%

Pretreatment Neutrophil/Lymphocyte Ratio as a Prognostic Aid in Colorectal Cancer

Özdemi̇r¹,

Akın²,

Sücüllü³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…From then on, a large number of clinical studies have been performed to understand the neutrophil-cancer relationship. Clinical data have often related elevated circulating neutrophil counts or elevated neutrophil-to-lymphocyte ratios (NLRs) as a predictive parameter for poor outcome and formation of distant metastasis in patients with epithelial malignancies [367], including lung [368,170], gastric [159,163,369], renal cell carcinoma [370], ovarian [141], hepatic [143,148,371], pancreatic [138], colon cancer [145,372], and colorectal carcinoma [152] (Table 3). However, Caruso et al [200] observed that when analyzing the amount of tumor-infiltrated neutrophils in advanced gastric carcinoma, in female but not male, patients with higher TANs had a favorable prognosis.…”

Section: Prognostic Values Of Neutrophils and Other Myeloid Subtypes mentioning

confidence: 99%

“…[145] Colon carcinoma, stage II Patients with elevated NLR had a worse overall survival and worse disease-free survival.…”

Section: Prognostic Values Of Neutrophils and Other Myeloid Subtypes mentioning

confidence: 99%

The Multifaceted Roles Neutrophils Play in the Tumor Microenvironment

Sionov

Fridlender

Granot

2014

Cancer Microenvironment

324

261

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Neutrophils are myeloid cells that constitute 50-70 % of all white blood cells in the human circulation. Traditionally, neutrophils are viewed as the first line of defense against infections and as a major component of the inflammatory process. In addition, accumulating evidence suggest that neutrophils may also play a key role in multiple aspects of cancer biology. The possible involvement of neutrophils in cancer prevention and promotion was already suggested more than half a century ago, however, despite being the major component of the immune system, their contribution has often been overshadowed by other immune components such as lymphocytes and macrophages. Neutrophils seem to have conflicting functions in cancer and can be classified into anti-tumor (N1) and pro-tumor (N2) sub-populations. The aim of this review is to discuss the varying nature of neutrophil function in the cancer microenvironment with a specific emphasis on the mechanisms that regulate neutrophil mobilization, recruitment and activation.

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Elevated preoperative neutrophil to lymphocyte ratio predicts risk of recurrence following curative resection for stage IIA colon cancer

Abstract: Elevated preoperative NLR is an independent predictor of worse RFS for patients with stage IIA colon cancer and a potential biomarker to identify candidates for adjuvant chemotherapy.

Cited by 199 publications

References 29 publications

Glasgow prognostic score predicts therapeutic outcome after hepatic resection for hepatocellular carcinoma

Glasgow prognostic score predicts therapeutic outcome after hepatic resection for hepatocellular carcinoma

Pretreatment Neutrophil/Lymphocyte Ratio as a Prognostic Aid in Colorectal Cancer

The Multifaceted Roles Neutrophils Play in the Tumor Microenvironment

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