Elevated Plasma Transforming Growth Factor β1 Levels Predict the Development of Hypertension in Normotensives: The 14-Year Follow-Up Study

Nakao, Erika; Adachi, Hisashi; Enomoto, Masaru; Fukami, Ako; Kumagai, Eita; Nakamura, Sachiko; Nohara, Yume; Kono, Shoko; Sakaue, Akiko; Morikawa, Nagisa; Tsuru, Tomoko

doi:10.1093/ajh/hpx053

Cited by 13 publications

(11 citation statements)

References 31 publications

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“…This pathway affects sodium handling in the kidney, ventricular remodelling, while plasma levels of TGFβ have recently been correlated with hypertension (Fig. 8)34,35. The activin A receptor type 1C ( ACVR1C ) gene mediates the effects of the TGFβ family of signalling molecules.…”

Section: Discussionmentioning

confidence: 99%

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Εvangelou¹,

Warren²,

et al. 2018

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High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic, pulse pressure) to date in over one million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also reveal shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.

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Section: Discussionmentioning

confidence: 99%

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Εvangelou¹,

Warren²,

et al. 2018

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“…This pathway affects sodium handling in the kidney, ventricular remodelling and recently plasma levels of TGFβ have been correlated with hypertension ( Fig. 7) 32,33 . The activin A receptor type 1C (ARVC) gene mediates the effects of the TGFβ family of signalling molecules.…”

mentioning

confidence: 99%

Genetic analysis of over one million people identifies 535 novel loci for blood pressure

Εvangelou¹,

Warren²,

Mosén-Ansorena³

et al. 2017

Preprint

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High blood pressure is the foremost heritable global risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits to date (systolic, diastolic, pulse pressure) in over one million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also reveal shared loci influencing lifestyle exposures. Our findings offer the potential for a precision medicine strategy for future cardiovascular disease prevention.peer-reviewed) is the author/funder. All rights reserved. No reuse allowed without permission.The copyright holder for this preprint (which was not . http://dx.doi.org/10.1101/198234 doi: bioRxiv preprint first posted online 1 0High blood pressure, defined as a systolic blood pressure >140 mm Hg and/or diastolic blood pressure > 90 mm Hg, is the dominant inherited risk factor for stroke and coronary artery disease and is responsible for an estimated 7.8 million deaths and 148 million disability life years lost worldwide in 2015 alone 1 . Family studies indicate that the blood pressure (BP) level is determined in an individual by complex interactions between life course exposures and their genetic background [2][3][4][5] . Previous genetic association studies have included genomewide meta-analyses, customised cardiovascular candidate centric analyses and evaluation of exome variation that have identified and validated variants at 274 loci which have a modest effect on population BP and explain ~3-4% of the trait variance [6][7][8][9][10][11][12][13] .Here, we report genome-wide discovery analyses of BP traits (systolic -SBP, diastolic -DBP and pulse pressure -PP) in people of European ancestry drawn from UK Biobank (UKB) 14 and the International Consortium of Blood Pressure-Genome Wide Association Studies (ICBP) 12,13 . We adopted a combination of a one and two-stage study design to test common and low-frequency single nucleotide polymorphisms (SNPs) with minor allele frequency (MAF) ≥ 1% in association with BP traits (Fig. 1) including over 1 million people of European descent across both discovery and replication, including data from the Million Veterans Program (MVP) and the Estonian Biobank.Briefly, UKB is a prospective cohort study of ~500,000 individuals recruited at ages 40-69 years who have been richly phenotyped including BP measurements 14 . Participants were genotyped using a customized array with imputation from the Haplotype Reference Consortium (HRC) panel, yielding ~7 million SNPs (imputation quality score (INFO) ≥ 0.1) 15 . After quality control (QC) and exclusions we performed genome-wide association studies (GWAS) of BP traits using data from 458,577 individuals of European descent under an additive genetic model 16 (Supplementary Table 1a). Following LD-score regression 17 , genomic control was applied to the UKB data prior to meta-analysis.In addition, we performed GWAS analyses for BP traits in the ICBP GWAS data comprising 77 independent s...

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“…В 2017 г. E. Nakao et al были опубликованы данные 14-летнего наблюдения за 500 нормотензивными представителями японской популяции. В ходе исследования установлено, что повышенный уровень ТФРβ1 служил предиктором развития АГ у данной группы пациентов [13]. В исследованиях M. Suthanthiran et al выялено, что в популяциях афроамерикацев и европеоидов с АГ уровни ТФРβ1 были выше, чем у лиц без АГ [14].…”

Section: артериальная гипертензия и трансформирующий фактор роста β1unclassified

Role of the Transforming Growth Factor Β1 in the Genesis of Arterial Hypertension and Its Complications

Левкович¹,

Pronko²

2021

Journal GrSMU

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Elevated Plasma Transforming Growth Factor β1 Levels Predict the Development of Hypertension in Normotensives: The 14-Year Follow-Up Study

Abstract: This is the first report demonstrating the causal relationship between them. Elevated plasma TGF-β1 levels predicted the development of hypertension in normotensives in a population of community-dwelling Japanese.

Cited by 13 publications

References 31 publications

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Genetic analysis of over one million people identifies 535 novel loci for blood pressure

Role of the Transforming Growth Factor Β1 in the Genesis of Arterial Hypertension and Its Complications

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