Role of the Transforming Growth Factor Β1 in the Genesis of Arterial Hypertension and Its Complications

Левкович, Т. В.; Pronko, T. P.

doi:10.25298/2221-8785-2021-19-1-16-22

Cited by 2 publications

(1 citation statement)

References 38 publications

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“…It is synthesized in almost all cells of the body, but most of it is contained in monocytes and macrophages. TGF-b1 is stored in a biologically inactive form in the extracellular matrix and is able to quickly transition to the active form under the influence of acidosis of surrounding tissues during hypoxia, which is due to increased expression in IHC study [21,22].…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical diagnosis of the viability of the strangulation furrow

Dudnyk

2021

Eureka: HS

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The aim of the research was to study the possibility of using immunohistochemical markers for the diagnosis of intravital stangulation. Materials and methods: Fragments of the neck skin from the strnaglulation zone were selected as objects of research. The main study group included 20 deaths due to hanging (10 men and 10 women). For the control group, 10 cases of acute coronary death (5 men and 5 women) were used. Using a complex of IHC markers, the labeling of the epidermis and epithelial structures, the features of cellular immune responses, the manifestation of oxidative steress were studied. Results: Peculiarities of morphological manifestations of strangulation furrow in mechanical asphyxia were studied. It is established that the key link of its morphogenesis is impaired vascular wall permeability with loss of type IV collagen in the basement membranes of epithelium and skin vessels, migration into tissues of activated CD15+ granulocytes, CD68+ macrophages and CD117+ labrocytes, endothelial nitric oxide synthase (eNOS), inducible nitric oxide synthase (iNOS), fibrinogen protein and transforming growth factor β1. Conclusion: Such changes in the tinctorial properties of skin and subcutaneous adipose tissue can be recorded by immunohistochemical (IHC) and serve as an important diagnostic criterion for the viability of the formation of the strangulation furrow.

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Section: Discussionmentioning

confidence: 99%

Immunohistochemical diagnosis of the viability of the strangulation furrow

Dudnyk

2021

Eureka: HS

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Influence of transforming growth factor-β on endothelial dysfunction in children with arterial hypertension

Revenko,

Kaladze,

Aleshina

et al. 2024

Pediatr (SPb)

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BACKGROUND: Chronic non-communicable cardiovascular diseases, including hypertension, started in childhood and adolescence. The presence and severity of early arterial changes is associated with the presence and severity of standard risk factors. Structural and functional disorders of the vascular bed in hypertension are represented by dysfunction of the compensatory dilating ability of the endothelium, a violation of the thickness of the intima-media complex of the common carotid arteries and a violation of the humoral, metabolic and myogenic regulation of vascular tone. AIM: To assess the severity of endothelial dysfunction and determine the significance of transforming growth factor-β (TGF-β) and endothelin-1 (ET-1) in its development in children with hypertension and metabolic syndrome. Materials and methods: 122 children with hypertension were examined. Along with a complete clinical, laboratory and instrumental examination, the concentration of TGF-β and ET-1 in the blood serum was determined. RESULTS: It was found that endothelial dysfunction was detected in children with hypertension, most pronounced in children with hypertension and metabolic disorders, the level of which increases with stabilization of the disease. Assessment is given as to possible development and progression of the disease and its favorable course depending on the dynamics of TGF-β profiles. Positive statistically significant correlations were obtained between the level of ET-1 and body mass index, waist circumference, blood pressure, and disease duration. CONCLUSIONS: The revealed results suggest that endothelial dysfunction in children with hypertension is involved in the formation and progression of hypertension and metabolic syndrome against the background of chronic inflammation processes.

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Role of the Transforming Growth Factor Β1 in the Genesis of Arterial Hypertension and Its Complications

Cited by 2 publications

References 38 publications

Immunohistochemical diagnosis of the viability of the strangulation furrow

Immunohistochemical diagnosis of the viability of the strangulation furrow

Influence of transforming growth factor-β on endothelial dysfunction in children with arterial hypertension

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