Elevated Plasma Stromal Cell-derived Factor 1 Protein and its Gene Polymorphism in Patients With Pelvic Inflammatory Disease

Tsai, Hsiu Ting; Tee, Yi Torng; Hsieh, Yi‐Hsien; Chiou, Hui‐Ling; Lin, Chiao‐Wen; Wang, Po Hui; Yang, Shun Fa

doi:10.1177/1933719109332829

Cited by 7 publications

(5 citation statements)

References 27 publications

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“…Of these transcripts, SDF-1 transcript variant 1 encodes circulating chemokine SDF-1α, which is the main SDF isoform in the blood. Plasma levels of this cytokine were found to be elevated in breast cancer (37), pelvic inflammatory disease (38) and in various systemic diseases (39–41). In ovarian cancer patients, using human cytokine microarray technology, plasma SDF-1 levels were found to be elevated 6.6-fold compared with the control group (42).…”

Section: Discussionmentioning

confidence: 99%

Expression of SDF-1 and CXCR4 transcript variants and CXCR7 in epithelial ovarian cancer

et al. 2014

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Chemokine stromal cell-derived factor-1 (SDF-1) and its receptors, CXCR4 and CXCR7, have been implicated in epithelial ovarian cancer progression and metastasis. However, limited data are available on the expression levels of SDF-1 and CXCR4 variants and CXCR7 in human epithelial ovarian cancer. The present study aimed to characterize the expression pattern and levels of SDF-1, CXCR4 and CXCR7 in normal human ovaries and epithelial ovarian cancer. The expression of SDF-1 and CXCR4 transcript variants and CXCR7 was determined by quantitative polymerase chain reaction (qPCR). Plasma SDF-1α levels were determined by commercially available EIA kits and cancer antigen 125 (CA 125) levels were quantified by automated microparticle enzyme immunosorbent assay. High expression levels of SDF-1 transcript variant 1 were identified in ovarian cancer and control ovaries. By contrast, in both groups the expression levels of SDF-1 transcript variants 3 and 4 were extremely low. Furthermore, SDF-1 variant 1 levels were notably higher in epithelial ovarian cancer than in control ovaries, while data for the remaining transcripts were similar in both groups. CXCR4 transcript variant 2 and CXCR7 expression levels in normal and neoplastic ovaries were similar. In both groups, CXCR4 transcript variant 2 was not detected. Plasma SDF-1α levels were notably higher in females with epithelial ovarian cancer than in the control ovaries. Elevated levels of blood SDF-1α were found prior to surgery, 6 days after surgery and following completion of the first chemotherapy course. These increases were independent of the type of epithelial ovarian cancer. Our results suggest that the expression of SDF-1 and the genes controlling alternative splicing are elevated in epithelial ovarian cancer, leading to an increased formation of SDF-1 variant 1. Elevated plasma SDF-1α levels in epithelial ovarian cancer patients are not associated with the presence of tumors and/or metastases, however reflect a general response to the disease.

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Section: Discussionmentioning

confidence: 99%

Expression of SDF-1 and CXCR4 transcript variants and CXCR7 in epithelial ovarian cancer

et al. 2014

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“…The action of CXCL12 chemokine is dependent on the presence of its receptor: CXCR4. Disrupted expression of both molecules has been observed in chronic and acute inflammation in, among others, the lungs, brain, joints and intestines (14)(15)(16). In patients with the active form of UC, the expression of CXCR4 receptor in the peripheral T cells was markedly higher as compared with the control, individuals potentially healthy.…”

Section: Discussionmentioning

confidence: 99%

Association of the-801G/A Polymorphism of CXCL12 Gene with the Risk of Inflammatory Bowel Diseases Development in a Polish Population

Mrowicki

Przybyłowska²,

Dziki³

et al. 2011

Polish Journal of Surgery

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Inflammatory bowel diseases (IBDs), mainly ulcerative colitis (UC) and Crohn's disease (CD), are characterized by chronic and idiopathic inflammatory conditions of gastrointestinal tract that are immunologically mediated. Stromal cell-derived factor 1 (CXCL12) has been demonstrated to be involved in the pathophysiology of IBD. the aim of the study was to investigate whether the cXcl12 -G/A polymorphism (rs1801157) is associated to IBD in a sample of Polish population. material and methods. A total of 188 patients with IBD including 103 patients with CU and 72 patients with CD and 184 controls were enrolled in the study. Both groups came from the Polish population. The G/A polymorphism of cXcl12 was determined by PCR-RFLP analysis.Results. There was no association between G/A polymorphism at position -801 promoter region of cXcl12 gene and increased risk of IBD. The study population was not found a difference in genotype distribution between the control group and with both CD and CU patients. conclusions. These results suggest that G/A polymorphism at position -801 promoter region of cXcl12 gene relates neither to the risk of the development of inflammatory bowel disease nor to the clinical subtypes of IBD in the Polish population. Whether this polymorphism truly contributes to disease susceptibility needs to be further addressed, and should stimulate additional studies in other populations.

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“…20 Moreover, plasma stromal cell-derived factor 1a level is elevated in patients with PID. 21 The D-dimer test indicates whether or not there is activation of the fibrinolytic system. Since D-dimer is generated from cross-linked fibrin, but not from fibrinogen, an elevated plasma concentration of D-dimer indicates recent or ongoing intravascular blood coagulation.…”

Section: Discussionmentioning

confidence: 99%

“…20 Moreover, plasma stromal cell-derived factor 1α level is elevated in patients with PID. 21…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Value of Serum d-Dimer Level for Tubo-Ovarian Abscess: A Cross-Sectional Pilot Study

et al. 2015

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Aim of this study is to investigate the diagnostic role of serum D-dimer levels for tubo-ovarian abscess (TOA). Patients diagnosed with TOA (n = 36) and matched controls with ovarian cysts (n = 39) were collected prospectively. Patients in the 2 groups were compared on the basis of size of TOA or cyst, demographic characteristics, and serum d-dimer levels. Baseline characteristics of both groups were comparable. Mean D-dimer levels were significantly higher (P < .0001) in patients with TOA (1870.6 ± 2401.7 ng/mL) when compared to adnexal cyst group (164.4 ± 81.1 ng/mL). D-Dimer had a diagnostic value of 99.9%, specificity of 100.0%, and sensitivity of 97.4% based on a cutoff value 314 ng/mL for predicting TOA. In conclusion, serum d-dimer level was significantly elevated in women with TOA compared with benign adnexal cysts. Thus, this inexpensive, feasible, and reproducible marker can be used for differential diagnosis of TOA.

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Elevated Plasma Stromal Cell-derived Factor 1 Protein and its Gene Polymorphism in Patients With Pelvic Inflammatory Disease

Cited by 7 publications

References 27 publications

Expression of SDF-1 and CXCR4 transcript variants and CXCR7 in epithelial ovarian cancer

Expression of SDF-1 and CXCR4 transcript variants and CXCR7 in epithelial ovarian cancer

Association of the-801G/A Polymorphism of CXCL12 Gene with the Risk of Inflammatory Bowel Diseases Development in a Polish Population

Diagnostic Value of Serum d-Dimer Level for Tubo-Ovarian Abscess: A Cross-Sectional Pilot Study

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