Elevated plasma orexin A levels in a subgroup of patients with schizophrenia associated with fewer negative and disorganized symptoms

Chien, Yi‐Ling; Liu, Chih-Min; Shan, Jia‐Chi; Lee, Hsin‐Jung; Hsieh, Ming H.; Hwu, Hai-Gwo; Chiou, Lih‐Chu

doi:10.1016/j.psyneuen.2014.12.012

Cited by 47 publications

(31 citation statements)

References 64 publications

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“…Finally, schizophrenia patients with high levels of orexin A, a neuropeptide that regulates arousal level, have lower levels of negative and disorganized symptoms, the symptoms most associated with cognitive impairment in this disorder ( Keri et al , 2005 ; Torniainen et al , 2012 ; Minor et al , 2015 ). They also have better cognitive functioning compared to patients with low levels of orexin A ( Chien et al , 2015 ). This suggests that arousal, as long as it is kept within tolerable limits ( Vijayraghavan et al, 2007 ; Hains and Arnsten, 2008 ; Hains et al , 2015 ), could be a cognition enhancing mechanism for schizophrenia.…”

Section: Genetic and Cognitive Impairments In Schizophrenia May Involmentioning

confidence: 99%

The effects of arousal on apical amplification and conscious state

et al. 2016

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Neocortical pyramidal cells can integrate two classes of input separately and use one to modulate response to the other. Their tuft dendrites are electrotonically separated from basal dendrites and soma by the apical dendrite, and apical hyperpolarization-activated currents (Ih) further isolate subthreshold integration of tuft inputs. When apical depolarization exceeds a threshold, however, it can enhance response to the basal inputs that specify the cell’s selective sensitivity. This process is referred to as apical amplification (AA). We review evidence suggesting that, by regulating Ih in the apical compartments, adrenergic arousal controls the coupling between apical and somatic integration zones thus modifying cognitive capabilities closely associated with consciousness. Evidence relating AA to schizophrenia, sleep, and anesthesia is reviewed, and we assess theories that emphasize the relevance of AA to consciousness. Implications for theories of neocortical computation that emphasize context-sensitive modulation are summarized. We conclude that the findings concerning AA and its regulation by arousal offer a new perspective on states of consciousness, the function and evolution of neocortex, and psychopathology. Many issues worthy of closer examination arise.

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Section: Genetic and Cognitive Impairments In Schizophrenia May Involmentioning

confidence: 99%

The effects of arousal on apical amplification and conscious state

et al. 2016

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“…Plasma orexin-A levels linearly correlate with its levels in cerebrospinal fluid (CSF) in humans, suggesting that plasma orexin-A levels are an easily accessible and reliable index of central orexin activity (Strawn et al, 2010). Clinical studies investigating changes in orexin-A levels following antipsychotic treatment in patients with schizophrenia have reported conflicting findings (Dalal et al, 2003; Basoglu et al, 2010; Chien et al, 2015). Chien et al (2015) reported that patients receiving chronic antipsychotic treatment had higher orexin-A levels compared with controls.…”

Section: Introductionmentioning

confidence: 99%

“…Clinical studies investigating changes in orexin-A levels following antipsychotic treatment in patients with schizophrenia have reported conflicting findings (Dalal et al, 2003; Basoglu et al, 2010; Chien et al, 2015). Chien et al (2015) reported that patients receiving chronic antipsychotic treatment had higher orexin-A levels compared with controls. Only 1 study has examined the association between orexin-A levels and metabolic parameters in patients with schizophrenia (Basoglu et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Orexin-A Levels in Relation to the Risk of Metabolic Syndrome in Patients with Schizophrenia Taking Antipsychotics

Chen

Chang

et al. 2018

International Journal of Neuropsychopharmacology

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Our results revealed that the orexin-A level was upregulated in patients with schizophrenia treated with antipsychotics, especially for the group taking less obesogenic antipsychotics. Furthermore, higher orexin-A levels were independently associated with better metabolic profiles. These observations suggest that an upregulation of orexin-A has a protective effect against the development of metabolic abnormalities in patients with schizophrenia receiving antipsychotic treatment.

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“…Indeed in patients diagnosed with schizophrenia, NPY levels in cerebrospinal fluid were correlated to social function and seemed to predict future outcomes (45). Similar functions have been described for orexin-A, a neuropeptide affecting thermogenesis and energy expenditure which has been described to modify metabolic risk in schizophrenia (46) while high levels have been correlated with fewer negative and disorganized symptoms (47). Although clinical GBA studies focusing on schizophrenia psychopathology remain scarce, they point toward a common pathway involving symptomatology, cognitive function, and clinical outcome.…”

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confidence: 63%

Antipsychotic-Induced Weight Gain and Clinical Improvement: A Psychiatric Paradox

García-Rizo

2020

Front. Psychiatry

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Elevated plasma orexin A levels in a subgroup of patients with schizophrenia associated with fewer negative and disorganized symptoms

Cited by 47 publications

References 64 publications

The effects of arousal on apical amplification and conscious state

The effects of arousal on apical amplification and conscious state

Orexin-A Levels in Relation to the Risk of Metabolic Syndrome in Patients with Schizophrenia Taking Antipsychotics

Antipsychotic-Induced Weight Gain and Clinical Improvement: A Psychiatric Paradox

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