Elevated Plasma Interleukin 6: A Biochemical Marker of Human Preterm Labour

Laham, Nihay; Rice, Gregory E.; Bishop, G. J.; Hansen, Morten Bagge; Bendtzen, Klaus; Brennecke, Shaun

doi:10.1159/000292614

Cited by 23 publications

(9 citation statements)

References 5 publications

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“…Previously, we have reported that immunoreactive IL-6 concentrations in maternal plasma increase significantly in association with preterm labour (Laham et al 1993). A similar increase in immunoreactive IL-6 concentration has been reported in amniotic fluid samples obtained from women in preterm labour associated with infection as indicated by positive amniotic fluid cultures (Romero et al 1990&, 1993, Leichty et al 1991, Santhanam et al 1991 or pathological evidence of chorioamnionitis (Hillier et al 1993, Saito et al 1993.…”

Section: Introductionsupporting

confidence: 69%

“…; ng/ml) before and after labour onset at term (>37 weeks) and preterm (20-36 weeks) Quantification of IL-6 in amniotic fluid and gestational tissue expiant conditioned medium was performed by sandwich ELISA, as previously described (Hansen et al 1991, Laham et al 1993). The assay utilised highavidity rabbit polyclonal antibodies, raised against purified recombinant human IL-6 and a biotin-streptavidin system for signal amplification.…”

Section: Experimental Designmentioning

confidence: 99%

See 1 more Smart Citation

Differential release of interleukin-6 from human gestational tissues in association with labour and in vitro endotoxin treatment

Laham

Brennecke²,

Bendtzen³

et al. 1996

Journal of Endocrinology

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In this study, we quantified interleukin-6 (IL-6) concentrations in amniotic fluid at term and preterm labour, and determined the gestational tissue source of IL-6. In addition, aspects of the regulatory mechanisms involved in IL-6 release at the time of term labour and in response to bacterial endotoxin, lipopolysaccharide (LPS), have been established. IL-6 concentrations were 2-fold higher in amniotic fluid collected at term compared with preterm gestation, with an additional 2-fold increase in association with term labour. IL-6 was released from all choriodecidual and placental explants but was detected in only 33% of amniotic explant cultures of tissues obtained before labour onset. In contrast, IL-6 was detected in all amniotic, choriodecidual and placental cultures of tissues obtained after term labour onset and delivery, and the mean IL-6 release was significantly higher than that measured in explant cultures of both amniotic (80-fold increase, P < 0.0001) and choriodecidual (3-fold increase, P < 0.02) but not placental explants taken at the time of elective Caesarean section at term before labour onset. LPS significantly (P < 0.05) increased the release of IL-6 from human choriodecidual and placental explants but not amniotic explants, in a time- and dose-dependent manner. IL-6 is a physiological constituent of amniotic fluid and its production by gestational tissues is differentially regulated by LPS and spontaneous labour onset and delivery.

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Section: Introductionsupporting

confidence: 69%

Section: Experimental Designmentioning

confidence: 99%

Differential release of interleukin-6 from human gestational tissues in association with labour and in vitro endotoxin treatment

Laham

Brennecke²,

Bendtzen³

et al. 1996

Journal of Endocrinology

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“…IL-6 has been the most studied with respect to preterm labour, with higher levels being found in maternal plasma in preterm labour compared to non-labouring gestationally matched controls [9]. Hillier et al [10] found that higher amniotic fluid levels of IL-6 predicted preterm delivery within 7 days of amniocentesis in afebrile women in threatened preterm labour with intact membranes.…”

Section: Discussionmentioning

confidence: 99%

Elevated Interleukin-8 Concentrations in Cervical Secretions Are Associated with Preterm Labour

Dowd¹,

Laham²,

Rice³

et al. 2001

Gynecol Obstet Invest

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The aim of this study was to assess the potential clinical utility of interleukin-8 (IL-8) present in cervical secretions as a marker of preterm labour and delivery. Samples of cervical mucus from 91 pregnant women were assessed for the presence and concentration of IL-8. Two samples were collected (at 18 ± 2 and 28 ± 2.5 weeks of gestation) and correlated with cervicovaginal microbiology and cervical length, as measured by transvaginal ultrasound. The IL-8 concentration at 28/40 was significantly higher in women who went on to deliver preterm (p < 0.01), and there was a greater than five-fold increase from 18 to 28 weeks in 6/7 of these women.

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“…Amniotic fluid concentrations of IL-6 appear to correlate with inevitable preterm delivery in association with intrauterine infection better than other parameters [21]. In addition, elevation of serum IL-6 has also been found to be associated with infection-associated preterm labour and inevitable preterm birth [22]. Greig et al [23] subsequently found that serum IL-6 concentrations were elevated in women with preterm premature rupture of the membranes who delivered soon after membrane rupture.…”

Section: Phases Of Parturitionmentioning

confidence: 99%

Maternal Risk Factors for Fetal and Neonatal Brain Damage

Terzidou

Bennett²

2001

Neonatology

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Prematurity is probably the major factor associated with brain damage in newborns. Our growing knowledge of the biochemical mechanisms leading to the onset of labour at term allows the biochemical correlates of the epidemiological risk factors for prematurity to be understood. Infection is the major cause of early preterm labour and is now recognised to be a major cause of fetal cerebral damage leading to cerebral palsy. Only some 5% of cerebral palsy is due to intrapartum asphyxia at term. This may occur due to an obstetric catastrophe or through inadequate placental function leading to chronic intrapartum asphyxia.

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Elevated Plasma Interleukin 6: A Biochemical Marker of Human Preterm Labour

Cited by 23 publications

References 5 publications

Differential release of interleukin-6 from human gestational tissues in association with labour and in vitro endotoxin treatment

Differential release of interleukin-6 from human gestational tissues in association with labour and in vitro endotoxin treatment

Elevated Interleukin-8 Concentrations in Cervical Secretions Are Associated with Preterm Labour

Maternal Risk Factors for Fetal and Neonatal Brain Damage

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