“…Relaxins, nuclear factor (NF)-kB and toll-like receptor (TLR)-2 are all part of the inflammatory cascade that result in term/preterm labor or weakening and rupture of FM (Bryant-Greenwood et al, 2009;Millar et al, 1998;Werner et al, 2005;Hoebe et al, 2004). The amniotic fluid in normal uncomplicated pregnancy shows elevated pro-inflammatory cytokines (IL-1, IL-6 and TNF-) with increasing gestation (Opsjln et al, 1993;Romero et al, 1990b;Laham et al, 1994Laham et al, & 1996, which is further increased during labor at term (Opsjln et al, 1993;Romero et al, 1990b;Laham et al, 1994;Cox et al, 1997;Maymon et al, 1999;Gunn et al, 1996;Romero et al, 1990aRomero et al, & 1992a. Infection during pregnancy further elevates the levels of these cytokines in amniotic fluid, FM and decidua .…”