2000
DOI: 10.1080/10715760000300171
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Elevated plasma homocysteine elicits an increase in antioxidant enzyme activity

Abstract: Elevated plasma homocysteine is considered to be a risk factor for cardiovascular disease. The mechanisms for this effect are not fully understood but there is some evidence for a role for reactive oxygen species (ROS). This study was conducted to explore the effects of elevated plasma total homocysteine (tHcy) concentration on activity of antioxidant enzymes in the circulation. The study group consisted of 10 patients with inherited defects of homocysteine metabolism, from whom 41 blood samples were collected… Show more

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Cited by 36 publications
(18 citation statements)
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“…Folic acid has been reported to act as a free radical scavenger [69], [70], and it is interesting to hypothesise a link between the discovery that (HUMAN)NAT1 and (MOUSE)NAT2 can act as AcCoA hydrolases in the presence of an appropriate amount of folic acid and a potential role for (HUMAN)NAT1/(MOUSE)NAT2 and folate in the regulation of AcCoA/CoA homeostasis in cells, especially under conditions of oxidative stress. The availability of naphthoquinone 1 as a selective inhibitor of folate-dependent AcCoA hydrolysis by (HUMAN)NAT1/(MOUSE)NAT2 adds to the available tool kit for the further investigation of such possibilities.…”
Section: Resultsmentioning
confidence: 99%
“…Folic acid has been reported to act as a free radical scavenger [69], [70], and it is interesting to hypothesise a link between the discovery that (HUMAN)NAT1 and (MOUSE)NAT2 can act as AcCoA hydrolases in the presence of an appropriate amount of folic acid and a potential role for (HUMAN)NAT1/(MOUSE)NAT2 and folate in the regulation of AcCoA/CoA homeostasis in cells, especially under conditions of oxidative stress. The availability of naphthoquinone 1 as a selective inhibitor of folate-dependent AcCoA hydrolysis by (HUMAN)NAT1/(MOUSE)NAT2 adds to the available tool kit for the further investigation of such possibilities.…”
Section: Resultsmentioning
confidence: 99%
“…With diminished GSH, Cys must provide much of the thiol-mediated antioxidant response of the cell, resulting in an increase in carbon flow from methionine through the methionine trans-sulfuration pathway, raising the levels of metabolic intermediates such as Hcy in Gclm(−/−) mice. Homocysteinemia has been shown to be associated with oxidative stress and an increase in antioxidant enzymes (Moat et al, 2000). A possible mechanism for this relationship may involve insulin.…”
Section: Discussionmentioning
confidence: 99%
“…In addition, betaine homocysteine methyltransferase (BHMT) is an enzyme responsible for remethylation of homocysteines to form methionine. Suppression of this enzyme can result in increased generation of homocysteine and an increased activity of antioxidant enzymes (Kharbanda et al, 2005;Moat et al, 2000). In a previous study, De Wit et al (2008) found that BHMT was down-regulated in the liver of zebrafish after TBBPA exposure, and concluded that this was a result of oxidative stress.…”
Section: Discussionmentioning
confidence: 99%