Elevated peripheral blood mononuclear cell count is an independent predictor of left ventricular remodeling in patients with acute myocardial infarction

Aoki, Satoshi; Nakagomi, Akihiro; Asai, Kuniya; Takano, Hitoshi; Yasutake, Masahiro; Seino, Yoshihiko; Mizuno, Kyoichi

doi:10.1016/j.jjcc.2010.10.003

Cited by 28 publications

(23 citation statements)

References 34 publications

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“…Patients were categorized according to whether they demonstrated LV remodeling post AMI, as assessed from the change (ΔLVEDV) in LVEDV between admission and follow-up. LV remodeling was defined as at least 10% increase from the baseline in LVEDV during follow-up [41]. For the assessment of the prognostic value of circulating miRNA levels, the cardiogenic death ( n = 19) or development of heart failure (clinical diagnosis ( n = 25), an ejection fraction <40% ( n = 61)) during follow-up was considered as primary endpoint.…”

Section: Methodsmentioning

confidence: 99%

Circulating miR-208b and miR-34a Are Associated with Left Ventricular Remodeling after Acute Myocardial Infarction

Zhou

et al. 2014

IJMS

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Left ventricular remodeling after acute myocardial infarction (AMI) is associated with adverse prognosis. It is becoming increasingly clear that circulating miRNAs could be promising biomarkers for various pathological processes in the heart, including myocardial infarction, myocardial remodeling and progression to heart failure. In the present study, a total of 359 consecutive patients were recruited. Plasma samples were collected on admission. Echocardiographic studies were performed during the admission and at six months follow-up after AMI. Remodeling was defined as an at least 10% increase from baseline in the left ventricular end-diastolic volume. Plasma miRNA levels were assessed for association with six months mortality or development of heart failure. Results showed that levels of plasma miR-208b and miR-34a were significantly higher in patients with remodeling than those without. Increased miRNA levels were strongly associated with increased risk of mortality or heart failure within six months for miR-208b (OR 17.91, 95% confidence interval = 2.07–98.81, p = 0.003), miR-34a (OR 4.18, 95% confidence interval = 1.36–12.83, p = 0.012) and combination of the two miRNAs (OR 18.73, 95% confidence interval = 1.96–101.23, p = 0.000). The two miRNA panels reclassified a significant proportion of patients with a net reclassification improvement of 11.7% (p = 0.025) and an integrated discrimination improvement of 7.7% (p = 0.002). These results demonstrated that circulating miR-208b and miR-34a could be useful biomarkers for predicting left ventricular remodeling after AMI, and the miRNA levels are associated with increased risk of mortality or heart failure.

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Section: Methodsmentioning

confidence: 99%

Circulating miR-208b and miR-34a Are Associated with Left Ventricular Remodeling after Acute Myocardial Infarction

Zhou

et al. 2014

IJMS

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“…As well as these data, CRP reflected myocardial injury (6,13). LVM and LVMI values were calculated by using the Devereux formula in order to assess the relationship between the myocardial mass and the CRP differences in two groups (14).…”

Section: Discussionmentioning

confidence: 99%

“…After acute coronary syndromes (ACS), as the time progresses, depending on the increase in inflammation, serum CRP levels are elevated. Blood CRP levels rise to peak level within 24-48 hours, and are decreased to normal levels within 3-7 days after ACS (5)(6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

The relationship between C-reactive protein and the lapse of time since the onset of the symptoms after acute myocardial infarction: an prospective-observational study

Gül

Aykan²,

Gökdeniz³

et al. 2014

Anadolu Kardiyol Derg

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Objective: It is important to know the elapsed symptom-to-door (StD) time between the emergence of ST-elevation myocardial infarction (STEMI) symptoms and admission to the hospital in terms of the selection of appropriate treatment and prognosis. In this study, we aimed to assess the relationship between serum C-reactive protein (CRP) and StD time after STEMI. Methods: 436 of the patients admitted to our center with STEMI between August 2012-February 2013 (338 male, mean age, 63.9±12.8) were included in this prospective-observational cohort study. Blood samples were obtained from laboratory results of the first reference period. Patients were divided into four groups according to the duration of StD time [0-1. hour; group 1 (G1), 1-3. hour; group 2 (G2), 3-6. hour; group 3 (G3), 6-12. hour; group 4 (G4)]. Statistical analysis was performed via chi-squre test, ANOVA test, Pearson's correlation analysis and receiver operator charecteristic (ROC) analysis. Results: As the time progressed, an increase in CRP levels was observed. The difference among the means of the G1-G3 (p=0.002), G1-G4 (p<0.001), G2-G4 (p<0.001) and G3-G4 (p<0.001) groups was found to be statistically significant. There was a good correlation between the StD time and CRP levels (r=0.676). ROC analysis of the predictive value of CRP for the third hour was determined as 0.78 mg/dL, respectively (AUC was 0.824; 95% C.I. was 0.785-0.859; 73.9% sensitivity, 78.1% specificity). Conclusion: According to serum CRP levels after STEMI at hospital admission, StD time can be estimated. (Anadolu Kardiyol Derg 2014; 14: 599-605)

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“…Remodelovanje LK je deinisano kao porast EDV indeksa LK ≥10 % na levoj ventrikulograiji nakon 6 meseci. 30 Yoon i saradnici su uključili 758 pacijenata sa AIM (STEMI i NSTE-MI) i praili ih 6 meseci. Porast EDV indeksa LK na ehokardiografskom pregledu nakon 6 meseci smatran je progresivnom dilatacijom LK.…”

Section: Funkcija Leve Komoreunclassified

“…U samo 4 istraživanja 20,27,28,31 korišćena je ehokardiografija, koja je najpogodnija i najdostupnija metoda u realnim uslovima. Ukupno gledano, u 6 studija je nađeno da postoji uicaj SH na posinfarktno remodelovanje LK 20,25,26,27,29,30 , dok u 2 to nije potvrđeno. 28,31 Rezultai većeg broja studija, kao i naši, da kod pacijenata sa SH u AIM dolazi češće do remodelovanja LK, mogu podržai stav da metaboličke abnormalnosi (SH) mogu dovesi do strukturnih promena i kliničkog pogoršanja (srčane insuicijencije i većeg mortaliteta).…”

Section: Funkcija Leve Komoreunclassified

Stress hyperglycemia in ST elevation myocardial infarction

Đorđević-Radojković¹,

Koraćević²,

Damjanović³

et al. 2014

Srce i krvni sudovi

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Klinika za kardiovaskularne bolesi, KC Niš Pregledni radStres hiperglikemija (SH) predstavlja povišen nivo glukoze u krvi, kao rezultat neurohumoralne akivacije u telu izloženom stresu. U akutnom infarktu miokarda (AIM) ona je udružena sa većim rizikom intrahospitalnog mortaliteta, ali još postoje kontroverze da li je marker povećanog dugoročnog rizika. Različiim mehanizmima hiperglikemija može imai direktne štetne efekte na ishemijski miokard, a insulinom posignuta normoglikemija može da umanji neke od njih. Visoka glikemija je značajniji prediktor lošeg ishoda kod pacijenata bez prethodnog DM nego kod dijabeičara. SH nije samo marker lošeg stanja već dovodi do pogoršanja funkcije LK tokom AIM. Pacijenima sa SH treba uradii HbA1c. Ukoliko je ≥ 6,5 %, smatra se da je pacijent dijabeičar. Ako postoji hiperglikemija na prijemu bez prethodnog DM, a HbA1c je <6,5 %, preporučuje se OGTT, 7 do 28 dana nakon AKS. Tokom hospitalizacije u jedinici intenzivne nege, insulin treba dai svim pacijenima sa glikemijom na prijemu ≥10,0 mmol/L, do ciljnih vrednosi 7,7-10 mmol/L. hiperglikemija, STEMI Sažetak Ključne rečiAutor za korespondenciju: Danijela Đorđević Radojković, Klinika za KVB, KC Niš, Abstract Stress hyperglycemia in ST elevaion myocardial infarcion Clinic for cardiovascular diseases, Clinical center of NisStress hyperglycemia (SH) is elevated plasma glucose level as result of acivaion of neurohormonal processes in the body exposed to stress. SH in AMI is associated with high risk of in-hospital mortality. It is sill controversial if SH is the marker of high post-hospital risk. Hyperglycemia can have direct detrimental efects on ischemic myocardium through diferent mechanisms. Normoglycemia achieved with insulin can reduce some of them. Hyperglycemia is more important predictor of bed outcome in paients without diabetes. SH is not only a marker of bed condiion, but causal factor of worsening LV funcion in AMI. In paients with SH, it is necessary to perform HbA1c. If it is ≥ 6.5%, paient is diabeic. If it is <6.5%, it is necessary to perform OGTT 7-28 days ater ACS. During hospitalizaion in ICU, paients with glycemia on admission ≥10.0 mmol/L should be treated with insulin to the targrt values 7.7-10 mmol/L.

show abstract

Elevated peripheral blood mononuclear cell count is an independent predictor of left ventricular remodeling in patients with acute myocardial infarction

Cited by 28 publications

References 34 publications

Circulating miR-208b and miR-34a Are Associated with Left Ventricular Remodeling after Acute Myocardial Infarction

Circulating miR-208b and miR-34a Are Associated with Left Ventricular Remodeling after Acute Myocardial Infarction

The relationship between C-reactive protein and the lapse of time since the onset of the symptoms after acute myocardial infarction: an prospective-observational study

Stress hyperglycemia in ST elevation myocardial infarction

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