Elevated monocyte-to-HDL cholesterol ratio predicts post-stroke depression

Abstract

ObjectivesInflammation plays an important role in the development of depression after stroke. Monocyte-to-HDL Cholesterol Ratio (MHR) recently emerged as a novel comprehensive inflammatory indicator in recent years. This study aimed to investigate whether there is a relationship between MHR levels and post-stroke depression (PSD).MethodsFrom February 2019 to September 2021, patients with acute ischemic stroke (AIS) were recruited within 7 days post-stroke from the two centers and blood samples were collected after admission. The 17-item Hamilton Depression Scale (HAMD-17) was used to measure depressive symptoms at 3 months after stroke. Patients were given the DSM-V criteria for diagnosis of PSD.ResultsOf the 411 enrolled patients, 92 (22.38%) patients were diagnosed with PSD at 3-months follow-up. The results also showed significantly higher level of MHR in patients with depression [0.81 (IQR 0.67–0.87) vs. 0.61 (IQR 0.44–0.82), P < 0.001] at admission than patients without depression. Multivariate logistic regression revealed that MHR (OR 6.568, 95% CI: 2.123–14.565, P = 0.015) was an independent risk factor for the depression at 3 months after stroke. After adjustment for potential confounding factors, the odds ratio of PSD was 5.018 (95% CI: 1.694–14.867, P = 0.004) for the highest tertile of MHR compared with the lowest tertile. Based on the ROC curve, the optimal cut-off value of MHR as an indicator for prediction of PSD was projected to be 0.55, which yielded a sensitivity of 87% and a specificity of 68.3%, with the area under the curve at 0.660 (95% CI: 0.683–0.781; P = 0.003).ConclusionElevated level of MHR was associated with PSD at 3 months, suggesting that MHR might be a useful Inflammatory markers to predict depression after stroke.

The Predictive Value of Monocyte/High-Density Lipoprotein Ratio (MHR) and Positive Symptom Scores for Aggression in Patients with Schizophrenia

“…Some scholars found the relevance of this class of inflammatory markers to psychiatric disorders. Such inflammatory markers have also been correlated with depressive disorders [ 35 , 36 ]. In 2021, Sahpolat et al first found significant differences in the MHR between patients with schizophrenia and healthy populations in a small sample study [ 37 ].…”

The blood monocyte to high density lipoprotein cholesterol ratio (MHR) is a possible marker of carotid artery plaque

“…The MHR is an indicator of atherosclerosis that evaluates inflammation and dyslipidemia [ 21 ]. As reported, the MHR can help to predict ischemic stroke and related complications [ 22 , 23 ] and is also related to extracranial and intracranial atherosclerotic stenosis [ 7 ]. In this study, it was found that there were differences in MHR, lipid, glucose, liver and renal function levels in subjects with different degrees of carotid plaque, suggesting that there were abnormalities in metabolism in people with carotid plaque.…”

Methamphetamine Use Disorder and Inflammation: A Case-Control Study

“…HDL performs antithrombotic, anti-inflammatory, and antioxidant activities. It protects the endothelium from the harmful effects of LDL and prevents LDL oxidation [ 32 - 34 ]. The monocyte/HDL ratio may be a novel inflammatory and oxidative stress indicator [ 16 ].…”

“…It protects the endothelium from the harmful effects of LDL and prevents LDL oxidation. [32][33][34] The monocyte/HDL ratio may be a novel inflammatory and oxidative stress indicator. 16 SII is a new inflammatory biomarker that accurately reflects the balance between inflammation and immune response.…”