Elevated mean platelet volume is associated with impaired coronary microvascular function in patients with idiopathic dilated cardiomyopathy

Abstract

Attenuated coronary flow reserve (CFR) has been reported in patients with idiopathic dilated cardiomyopathy (IDC). On the other hand increased platelet activity has been demonstrated in patients with congestive heart failure and left ventricular dysfunction. Accordingly, we aimed to investigate whether mean platelet volume (MPV) is increased in patients with IDC and increased MPV correlates with the degree of coronary microvascular dysfunction. MPV was measured in 37 patients with IDC. Each patient with IDC also underwent echocardiographic examination including CFR measurement. Patients with IDC were divided into two groups based on median CFR value (lower CFR group and normal CFR group). MPV was significantly higher in the lower CFR group than in the normal CFR group (9.00 ± 0.56 vs. 8.25 ± 0.76 fl; respectively, p = 0.001). CFR correlated significantly and inversely to MPV (r = -0.475, p = 0.003). Logistic regression analysis revealed that MPV level was the independent predictor of lower CFR (β = -0.750, p = 0.002). Furthermore, MPV was an accurate predictor of low CFR (p = 0.001); Area under the curve was 82% (95% CI 0.67-0.96). The best cut-off value of MPV to predict low CFR was 8.3 fl with 95% sensitivity and 69% specificity. In conclusion, the present study showed a negative correlation between MPV and CFR in patients with IDC.

The New Diagnostic Marker For Acute Pulmonary Embolism In Emergency Department; Mean Platelet Volume

“…Previous studies have shown that MPV is a marker of platelet function and is positively associated with indicators of platelet activity [5][6][7]9 . Recently, clearly known that increased MPV is shown more reactive platelets.…”

“…MPV is an indicator of platelet activation and there is strong evidence indicating that MPV is an important variable and that larger platelets have a higher thrombotic potential 5,6 . Elevated MPV has been recognized as an independent risk factor for different clinical conditions [7][8][9] .…”

Relationship between the elevated mean platelet volume and coronary microvascular function in patients with idiopathic dilated cardiomyopathy

“…Larger platelets may play a role in the pathogenesis of microvascular dysfunction through the secretion of prothrombotic, vasoconstrictor, and inflammatory mediators. So, in the light of this study [1], in patients with dilated idiopathic cardiomyopathy, high MPV could be considered as a biomarker of impairment of coronary flow. Therefore, in this group of patients, it can be suggested that new studies should be carried out in order to assess if tailoring therapy can impact on microcirculatory function.…”

“…We have read with great interest the recently published report of Erdogan et al [1], related to the relationship of mean platelet volume (MPV) and coronary microvascular function in patients with idiopathic dilated cardiomyopathy. In this recent study, patients with idiopathic dilated cardiomyopathy have underwent echocardiographic examination including coronary flow reserve (CFR) measurement, and patients with lower CFR were found to have higher MPV values.…”

Mean platelet volume as a surrogate marker of low-grade inflammation in osteoarthritis

“…MPV is a widely used laboratory marker associated with platelet function based on inflammatory conditions [5,6]. The MPV also represents platelet function, which is central to processes that are involved in coronary heart disease pathophysiology and endothelial dysfunction [7][8][9]. Platelet parameters might be influenced by coronary risk factors including age, obesity, smoking, diabetes mellitus, hypertension, hyperlipidemia, metabolic syndrome and deep vein thrombosis [6,10].…”