1998
DOI: 10.1177/039139889802100204
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Elevated levels of tumor necrosis factor alpha in postdialysis fatigue

A.W. Dreisbach,
T. Hendrickson,
D. Beezhold
et al.

Abstract: Postdialysis fatigue (PDF) has been ascribed to excessive ultrafiltration and decline in osmolality during hemodialysis. We evaluated the potential role for the sommogenic cytokines, interleukin-1 beta (IL-1β) and tumor necrosis factor alpha (TNFα), in the genesis of PDF. Patients dialyzing with cuprophane membrane were assigned to PDF (N=25) and non-PDF (N=25) groups based on a fatigue index questionnaire. Pre- and postdialysis samples were obtained from 3 consecutive treatments and later assayed for serum le… Show more

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Cited by 33 publications
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“…The causes and the pathogenesis of PDF are essentially unknown [ 1 , 2 , 3 , 4 ]. However, some mechanisms have been proposed, such as the rapid decline in osmolarity occurring during dialysis as result of the combined effect of a reduction in serum urea and sodium concentration (this leads to brain swelling and headache, restlessness, nausea, muscle cramps and fatigue [ 5 , 6 ]; the release of cytokines such as interleukin-1, interleukin-6 and tumor necrosis factor-alpha [ 7 , 8 , 9 ]; the accumulation of metabolites and toxins in the muscle [ 10 ]).…”
Section: Introductionmentioning
confidence: 99%
“…The causes and the pathogenesis of PDF are essentially unknown [ 1 , 2 , 3 , 4 ]. However, some mechanisms have been proposed, such as the rapid decline in osmolarity occurring during dialysis as result of the combined effect of a reduction in serum urea and sodium concentration (this leads to brain swelling and headache, restlessness, nausea, muscle cramps and fatigue [ 5 , 6 ]; the release of cytokines such as interleukin-1, interleukin-6 and tumor necrosis factor-alpha [ 7 , 8 , 9 ]; the accumulation of metabolites and toxins in the muscle [ 10 ]).…”
Section: Introductionmentioning
confidence: 99%