2003
DOI: 10.1007/978-1-4615-0323-1_8
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Cytokines and Sleep Regulation

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Cited by 10 publications
(8 citation statements)
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References 86 publications
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“…This variability could not be used to predict basic electrophysiological characteristics nor responses to SCN stimulation. An interesting feature of these VLPO neurons was that some dendrites appear to reach the ventral surface of the brain, suggesting that these neurons might detect substances distributed through the CSF, including those implicated in sleep regulation, such as cytokines, brain lipids and adenosine (Krueger & Fang, 1999). Similar observations have been reported for cortically projecting basal forebrain neurons (Semba et al, 1987), which are implicated in regulation of cortical activation.…”
Section: Characterization and Identi®cation Of Recorded Neuronssupporting
confidence: 67%
“…This variability could not be used to predict basic electrophysiological characteristics nor responses to SCN stimulation. An interesting feature of these VLPO neurons was that some dendrites appear to reach the ventral surface of the brain, suggesting that these neurons might detect substances distributed through the CSF, including those implicated in sleep regulation, such as cytokines, brain lipids and adenosine (Krueger & Fang, 1999). Similar observations have been reported for cortically projecting basal forebrain neurons (Semba et al, 1987), which are implicated in regulation of cortical activation.…”
Section: Characterization and Identi®cation Of Recorded Neuronssupporting
confidence: 67%
“…As already mentioned and reviewed in detail earlier, 8 there is convincing evidence in animals that inflammatory cytokines, in particular IL‐1β and TNF‐α, are the most important mediators of the increased amount and intensity of nonREM sleep during infections. A major role of these immune mediators in human sleep responses to infection is very probable, too, although the mechanisms are likely to be not identical.…”
Section: Mechanisms Underlying the Effects Of Immunomodulation On Slementioning
confidence: 67%
“…For unknown reasons rats and rabbits typically do not show reductions in nonREM sleep amount and increased wakefulness during infections or comparable experimental conditions that induce fever. 7,8 The increase in rectal temperature by itself cannot explain nonREM sleep suppression in humans, because passive body heating has opposite effects. 33,34 In our view, the most probable explanation at present is that HPA system activation, which becomes very prominent only in the febrile host response range, causes disturbed sleep through central CRH release, well known to suppress nonREM sleep.…”
Section: Mechanisms Underlying the Effects Of Immunomodulation On Slementioning
confidence: 99%
See 1 more Smart Citation
“…Both IL1 and TNF seem to be key components of the physiological sleep homeostat Krueger et al, 1995;Krueger and Obal, 1997;Vitkovic et al, 2000;Obal and Krueger, 2003). Consistent with current results, they affect each other's production and inhibition of one attenuates the sleep induced by the other (Takahashi et al, 1999.…”
Section: Discussionmentioning
confidence: 99%