Elevated levels of Th17 cells and Th17-related cytokines are associated with disease activity in patients with inflammatory bowel disease

Jiang, Wenyu; Su, Jiewen; Zhang, Xiaofei; Cheng, Xianzhong; Zhou, Jun; Shi, Ruihua; Zhang, Hongjie

doi:10.1007/s00011-014-0768-7

Cited by 140 publications

(110 citation statements)

References 27 publications

(26 reference statements)

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“…Exposure of PBMC-derived Th17 cells to UCB resulted in an increase in the frequency of IL-10-producing cells ( Figure 2A); this increase was mirrored by increases in the IL-10 mean fluorescence intensity (MFI) ( Figure 2B) and mRNA levels ( Figure 2C). UCB, however, did not alter other aspects of the Th17 cell phenotype, as reflected by levels of IL-17, RAR-related orphan receptor C (RORC), IL-23 receptor (IL-23R), and CCR6 expression ( Figure 2D), but rather diminished the expression of IL-22 and IL-1β, cytokines typically expressed by pathogenic Th17 cells ( Figure 2E) (33,34). UCB markedly abrogated Th17 cell proliferation ( Figure 2F) without, however, increasing the cell apoptotic rate, as determined by the frequency of annexin V + cells ( Figure 2G).…”

Section: Resultsmentioning

confidence: 99%

Bilirubin suppresses Th17 immunity in colitis by upregulating CD39

et al. 2017

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Section: Resultsmentioning

confidence: 99%

Bilirubin suppresses Th17 immunity in colitis by upregulating CD39

et al. 2017

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“…The presence of deregulated cytokines and chemokines has been previously reported in cases of IBD, primarily in studies performed at the level of the inflamed mucosa, while studies on the circulating levels of cytokines and chemokines in IBD are less frequent (14)(15)(16)(17). Among the panel of cytokines and chemokines investigated in the present study, 10 proteins, including IL-1β, IL-5, IL-7, IFN-α2, IFN-γ, IP-10, CTACK, IL-16, MIG and LIF, were shown to be significantly upregulated in the group of pediatric IBD patients, as compared with the age-matched controls.…”

Section: Discussionmentioning

confidence: 99%

Pediatric patients with inflammatory bowel disease exhibit increased serum levels of proinflammatory cytokines and chemokines, but decreased circulating levels of macrophage inhibitory protein-1β, interleukin-2 and interleukin-17

Kleiner¹,

Zanin²,

Monasta³

et al. 2015

Experimental and Therapeutic Medicine

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Abstract. Inflammatory bowel disease (IBD) is a chronic and progressive inflammatory condition of the gastrointestinal tract. Although the causative events that lead to the onset of IBD are yet to be fully elucidated, deregulation of immune and inflammatory mechanisms are hypothesized to significantly contribute to this disorder. Since the onset of IBD is often during infancy, in the present study, the serum values of a large panel of cytokines and chemokines in pediatric patients (<18 years; n=26) were compared with age-matched controls (n=37). While elevations in the serum level of several proinflammatory and immune regulating cytokines were confirmed, such as interleukin (IL)-1β, IL-5, IL-7, interferon (IFN)-γ-inducible protein-10, IL-16, cutaneous T-cell-attracting chemokine, leukemia inhibitory factor, monokine induced by γ-IFN, IFN-α2 and IFN-γ, notably decreased levels of IL-2, IL-17 and macrophage inhibitory protein-1β were also observed. Therefore, while a number of proinflammatory cytokines exhibit increased levels in IBD patients, pediatric IBD patients may also exhibit certain aspects of a reduced immunological response.

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“…IL-17 as well as Th17 cells have been identified as having an increased serum and intestinal tissue level in IBD patients [50]. IL-17 has not been identified in the tissues of inactive patients or other types of colitis [51].…”

Section: Pro-inflammatory Cytokinesmentioning

confidence: 99%

“…IL-21 is expressed by T cells, B cells and non-immune cells, like fibroblasts. IL-21 contributes to the differentiation of Th17 cells [65], with an over expression in both CD and UC [50]. The highest levels were identified in CD [66].…”

Section: Other Cytokines With Roles In Ibdsmentioning

confidence: 99%

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Cytokines in inflammatory bowel disease

Moldoveanu

Diculescu

Braticevici

2015

Romanian Journal of Internal Medicine

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Inflammatory bowel diseases are chronic afflictions, characterized by active and remission periods. Inflammation is the most common type of response that the human body uses as a defense mechanism against aggressors from the environment. The frequency and degree of inflammation depends on the size of the affected tissues. The gastrointestinal tract is, by far, the most susceptible tissue to inflammatory responses, because of its constant exposure to various antigenic, mutagenic and toxic factors. In inflammatory bowel diseases there is a loss of immune tolerance to intestinal flora that is mediated by various substances, including cytokines. Cytokines represent a key signal in the intestinal immune response. Activated dendritic cells and macrophages secrete cytokines that actively intervene in inflammation regulation, in both Crohn’s disease and ulcerative colitis. After their secretion by antigen presented cells, cytokines activate and differentiate T cells, stirring up the adaptive immune response. Cytokines have an important role in the pathogenesis of inflammatory bowel diseases. The identification of new cytokines, as well as the changing of the pathogenesis paradigms in inflammatory bowel diseases has been done on animal tests and clinical studies. Thus, there is promising evidence basis for future therapy research based on cytokines, and anti-cytokine antibodies.

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Elevated levels of Th17 cells and Th17-related cytokines are associated with disease activity in patients with inflammatory bowel disease

Abstract: Th17 cells and Th17-related cytokines (IL-17, IL-21 and IL-22) were increased in the intestinal mucosa in active IBD patients and may play an important role in disease activity and mucosal damage.

Cited by 140 publications

References 27 publications

Bilirubin suppresses Th17 immunity in colitis by upregulating CD39

Bilirubin suppresses Th17 immunity in colitis by upregulating CD39

Pediatric patients with inflammatory bowel disease exhibit increased serum levels of proinflammatory cytokines and chemokines, but decreased circulating levels of macrophage inhibitory protein-1β, interleukin-2 and interleukin-17

Cytokines in inflammatory bowel disease

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