Elevated levels of serum lipoprotein(a) and apolipoprotein(a) phenotype are not related to pre‐eclampsia

Abstract

Lipoprotein(a) and apolipoprotein(a) phenotype do not contribute significantly to the pathogenesis of pre-eclampsia.

Risk Factors for Cardiovascular Disease in Women with a History of Pregnancy Complicated by Preeclampsia or Intrauterine Growth Restriction

“…Two studies in the literature report on Lp(a) in women with a history of preeclampsia, the study of Leerink et al (30) and that of van Pampus et al (31) The results of our study are in agreement with those of Leerink et al (30), who found unaltered levels of Lp(a) in women with a history of preeclampsia on the Dutch Antilles. The results of our study are, however, in disagreement with the results of the study by van Pampus et al (31), who found higher Lp(a) concentrations in Dutch women with a history of severe preeclampsia.…”

Potential atherogenic roles of lipids, lipoprotein(a) and lipid peroxidation in preeclampsia

“…However, controversy still exists in the obstetric literature regarding this hypothesis. Some studies [15,16] favor higher Lp(a), like ours, while other studies report no difference [6,18,19]. Wang and colleagues [8] reported a marked (5-10-fold) elevation in median Lp(a) concentrations in moderate and severe preeclampsia compared with normal controls.…”

Lipoprotein(a) levels in women with pre‐eclampsia and in normotensive pregnant women

“…Lipoprotein(a) levels were also investigated in women with a history of pre‐eclampsia. Both Lp(a) levels and apo(a) phenotype distribution were equal in patients with, and without, a history of pre‐eclampsia 25 . Kim et al .…”