Risk Factors for Cardiovascular Disease in Women with a History of Pregnancy Complicated by Preeclampsia or Intrauterine Growth Restriction

Manten, G. T. R.; Sikkema, Marko; Voorbij, H. A. M.; Visser, Gerard H.A.; Bruinse, Hein W.; Franx, Arie

doi:10.1080/10641950601146574

Cited by 138 publications

(118 citation statements)

References 35 publications

(48 reference statements)

Supporting

Mentioning

102

Contrasting

Unclassified

Order By: Relevance

“…26,49 Furthermore, previous studies have showed a decreased nocturnal serum melatonin in coronary heart disease and during acute myocardial infarction. 50,51 This approach raises new questions regarding the mechanism of endothelial dysfunction in preeclampsia and suggests that melatonin might be somehow involved.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Melatonin secretion is impaired in women with preeclampsia and an abnormal circadian blood pressure rhythm

et al. 2014

View full text Add to dashboard Cite

Non-dipping circadian blood pressure (BP) is a common finding in preeclampsia, accompanied by adverse outcomes. Melatonin plays pivotal role in biological circadian rhythms. This study investigated the relationship between melatonin secretion and circadian BP rhythm in preeclampsia. Cases were women with preeclampsia treated between January 2006 and June 2007 in the University Hospital of Larissa. Volunteers with normal pregnancy, matched for chronological and gestational age, served as controls. Twenty-four hour ambulatory BP monitoring was applied. Serum melatonin and urine 6-sulfatoxymelatonin levels were determined in day and night time samples by enzyme-linked immunoassays. Measurements were repeated 2 months after delivery. Thirty-one women with preeclampsia and 20 controls were included. Twenty-one of the 31 women with preeclampsia were non-dippers. Compared to normal pregnancy, in preeclampsia there were significantly lower night time melatonin (48.4 ± 24.7 vs. 85.4 ± 26.9 pg/mL, p50.001) levels. Adjustment for circadian BP rhythm status ascribed this finding exclusively to non-dippers (p50.01). Two months after delivery, in 11 of the 21 non-dippers both circadian BP and melatonin secretion rhythm reappeared. In contrast, in cases with retained non-dipping status (n ¼ 10) melatonin secretion rhythm remained impaired: daytime versus night time melatonin (33.5 ± 13.0 vs. 28.0 ± 13.8 pg/mL, p ¼ 0.386). Urinary 6-sulfatoxymelatonin levels were, overall, similar to serum melatonin. Circadian BP and melatonin secretion rhythm follow parallel course in preeclampsia, both during pregnancy and, at least 2 months after delivery. Our findings may be not sufficient to implicate a putative therapeutic effect of melatonin, however, they clearly emphasize that its involvement in the pathogenesis of a non-dipping BP in preeclampsia needs intensive further investigation.

show abstract

Section: Discussionmentioning

confidence: 99%

“…51 In addition, the non-dipping pattern of circadian BP has been associated with a large increase in cardiovascular morbidity, reflecting an increased risk of target organ damage. 54 Our results showed a decreased melatonin secretion in women with a recent history of preeclampsia and nocturnal hypertension.…”

Section: Daytimementioning

confidence: 99%

Melatonin secretion is impaired in women with preeclampsia and an abnormal circadian blood pressure rhythm

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Among women with preeclampsia, common cardiometabolic risk factors, such as elevated BP, cholesterol, and HOMA‐IR (Homeostatic Model Assessment of Insulin Resistance) scores, become evident as early as within the first year postpartum 71. This suggests that early screening and intervention for these modifiable risk factors may be an effective prevention strategy, although this has never been directly tested.…”

Section: Current Guidelines and Recommendationsmentioning

confidence: 99%

Hypertensive Disorders of Pregnancy and Future Maternal Cardiovascular Risk

Ying

Catov

Ouyang

2018

JAHA

179

119

View full text Add to dashboard Cite

“…2,3,13,14,22 Even the 10-year CVD risk in women with a history preeclampsia is significantly higher with an odds ratio of 1.31 according to the Framingham risk score. 23 Therefore, in our study, the presence Data are presented as number and percentage.…”

Section: Discussionmentioning

confidence: 99%

“…12 For preeclampsia and fetal growth restriction, previous studies on postpartum CVD risk factors revealed a higher prevalence of multiple modifiable risk factors for CVD within the first year after delivery. 5,13,14 However, to date this has not been separately studied for women with previous placental abruption. In this study, we assessed common CVD risk factors in women with a history of placental abruption at 6 to 12 months after delivery, in comparison with a control group of women with a history of only uneventful pregnancies.…”

mentioning

confidence: 99%

Maternal Cardiovascular Risk Profile After Placental Abruption

Veerbeek

Smit²,

Koster³

et al. 2013

Hypertension

Self Cite

View full text Add to dashboard Cite

All women with a pregnancy complicated by placental abruption who delivered at the University Medical Center Utrecht, The Netherlands, between November 1994 and December 2009 were considered to Abstract-The prevalence of premature cardiovascular diseases (CVD) is increased in women with a history of maternal placental syndromes, including pregnancy-associated hypertensive disorders (eg, preeclampsia), fetal growth restriction, and placental abruption. Whereas previous studies have shown a high prevalence of CVD risk factors after pregnancies complicated by preeclampsia, this has not been studied for women with a history of placental abruption. To explore the association of placental abruption with CVD risk factors after delivery, we compared 75 women with a history of placental abruption with a control group of 79 women with uneventful pregnancies at 6 to 9 months postpartum for the presence of common CVD risk factors. In a subanalysis, data were stratified according to the presence or absence of concomitant hypertensive disease and further adjusted for potential confounders. Women with previous placental abruption had significantly higher mean systolic blood pressure, body-mass index, fasting blood glucose, C-reactive protein, total cholesterol, high-density lipoprotein-cholesterol, and low-density lipoprotein-cholesterol as compared with controls with only uneventful pregnancies. In the subanalysis, all differences remained significant for women with a history of placental abruption only (ie, without concomitant gestational hypertension), except for the associations with low-density lipoprotein-cholesterol and diastolic and systolic blood pressure. Most likely, the identified CVD risk factors predispose to placental abruption and development of premature CVD later in life. (Hypertension. 2013;61:1297-1301.)

show abstract

Risk Factors for Cardiovascular Disease in Women with a History of Pregnancy Complicated by Preeclampsia or Intrauterine Growth Restriction

Abstract: Preeclampsia or IUGR may represent an early marker for increased risk for early cardiovascular disease.

Cited by 138 publications

References 35 publications

Melatonin secretion is impaired in women with preeclampsia and an abnormal circadian blood pressure rhythm

Melatonin secretion is impaired in women with preeclampsia and an abnormal circadian blood pressure rhythm

Hypertensive Disorders of Pregnancy and Future Maternal Cardiovascular Risk

Maternal Cardiovascular Risk Profile After Placental Abruption

Contact Info

Product

Resources

About