Elevated level of antisperm antibodies as a risk factor for unfavorable pregnancy outcome after use of assisted reproductive technology

Почерников, Д. Г.; Герасимов, А.М.; Гусейнова, С. Г.; Наумов, Н. П.

doi:10.17650/2070-9781-2019-20-1-69-74

Cited by 3 publications

(2 citation statements)

References 13 publications

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“…У літературі наведені дані про негативний вплив АСАТ на ембріогенез, імплантацію ембріона, перебіг вагітності та на можливість запліднення яйцеклітини як in vivo, так і in vitro [6]. Автори припускають, що реакція на антигени сперматозоїдів націлює імунну систему жінки на антигени чоловіка, які містяться в ембріоні [7].…”

Section: мар-тест и показатели спермиологического исследования ка вла...unclassified

MАR-test and Spermiological Research Indices

Vladychenko

Fedoruk

Yuzko

et al. 2021

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Antisperm antibodies are detected in 3% to 25% of cases in men and women diagnosed with infertility. They can also be diagnosed in 1–10% of healthy fertile men. The presence of a high titer of AST is one of the factors of male infertility, which can be «hidden», i. e. not cause symptoms and deterioration of the overall spermogram. The objective: to analyze the results of sperm testing in men with antisperm antibodies, which were detected by MAR-test. Material and methods. A retrospective analysis of the examination results of 555 men was conducted on the basis of the Medical Center for Infertility Treatment in Chernivtsi. Spermograms were examined according to WHO recommendations in 2000, using an inverted microscope Olympus CKX41 in a Broker chamber. Determination of the percentage of sperm coated with antisperm antibodies was performed using the MAR-test (MAR-test, MAR-mixed antiglobulin reaction). Results. If we calculate the percentage of patients in whom we assume the connection between the presence of antisperm antibodies and undertaken surgery, genital infections and allergy history, we get only 48.3% of cases. It has been found that most changes in sperm counts correlate with the percentage of sperm that are coated with IgG. These data indicate that increased IgG levels play an important role in the development of pathospermia. A negative medium-strength correlation was found between the percentage of Category A sperm and the percentage of IgG-coated sperm. Persistence of IgG in semen is accompanied by a probable decrease in the morphological quality of sperm. Conclusion. In 52% of patients it was not possible to establish the etiological factor for the presence of Ig in the ejaculate. It has been found that most changes in sperm counts correlate with the percentage of sperm that are coated with IgG. It has been determined that an increase in the level of IgA and IgG leads to a probable increase in the percentage of pathological sperm forms and decrease in sperm motility. In the presence of 30% of sperm that are coated with IgG, with a probability of 95%, the ejaculate of patients will have 100% of pathologicoalr mf s of sperm.

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Section: мар-тест и показатели спермиологического исследования ка вла...unclassified

MАR-test and Spermiological Research Indices

Vladychenko

Fedoruk

Yuzko

et al. 2021

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“…[3,6]. Несмотря на то что ряд исследований продемонстрировал эффективность данной группы препаратов, только 50 % мужчин, обратившихся за медицинской помощью в связи с идиопатическим бесплодием, можно помочь медикаментозно, тогда как остальные в большинстве случаев нуждаются в дорогостоящих процедурах вспомогательных репродуктивных технологий [7]. В настоящее время все более широкое применение в андрологической практике находит низкоинтенсивная лазерная терапия (НИЛТ) -физиотерапевтический метод лечения, основанный на медицинском применении света, не вызывающий нагревания тканей от лазерных источников оптического излучения.…”

Section: Introductionunclassified

Our experience of application of low-level laser therapy in red spectrum in male idiopathic secretory infertility

Potapova

Кирилловна²,

Borovets

et al. 2020

Urology reports (St. - Petersburg)

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Introduction. Due to insufficient efficacy of medical therapy of idiopathic secretory male infertility there is a need to develop and apply more resultative methods of treatment. The aim of our study was to assess the efficacy of low-level laser therapy (LLLT) in red spectrum on sperm parameters, sperm DNA fragmentation (SDNAF) and MAR-test rate in men with idiopathic infertility. Patients and methods. 85 men with idiopathic infertility were examined, 50 of them (first group) were treated with LLLT and 35 (second group) didnt have course of LLLT. Average age of patients of the first and second groups was 31.4 1.3 and 32.3 1.4 years. LLLT was performed in red spectrum on a Rubin-C device (Russia). 10 laser therapy procedures were carried out every two days with active luminescence for 10 minutes of both testicles. Male hormone panel, semen analysis, MAR-test, SDNAF were assessed before and after the treatment. Results. LLLT in patients of the first group resulted in significant increase in ejaculate volume, sperm viability, number of morphologically normal sperm forms (by an average of 11, 9 and 23% respectively), and active mobile sperm forms by an average of 14 and 19% one and two months after the therapy respectively. In 12 patients of the first group with initially increased SDNAF its level became normal after the treatment. Significant decrease of MAR-test we searched out in patients of the first group with its initial level less than 30%. As a result of the treatment, pregnancies developed in 10 (20%) out of 50 couples in the first group. Conclusions. LLLT in red spectrum leads to significant improvement of sperm quality in patients with idiopathic infertility, normalizes sperm DNA-fragmentation level and decreases MAR-test level.

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Male autoimmune infertility: analysis of results and prediction of efficacy of low-level laser therapy in infrared spectrum

Potapova

Borovets

Аль-Шукри

2021

Urology reports (St. - Petersburg)

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INTRODUCTION: Autoimmune infertility is diagnosed in 515% of men. Currently applied methods of medical therapy of autoimmune male infertility are not very effective, which requires the development of new ones and creation of predictive algorithms for their efficacy. The aim of our study was to evaluate the influence of low-level laser therapy (LLLT) in infrared spectrum on MAR-test rate and sperm fertile properties in men with autoimmune infertility, develop ways to predict the efficacy of this therapy. PATIENTS AND METHODS: 47 men with autoimmune infertility were examined. 31 of them (1st group) underwent course of LLLT in infrared spectrum (10 procedures), and 16 patients (2nd group, comparison) had placebo-laser therapy sessions (10 procedures). MAR-test value, main semen parameters and sperm DNA fragmentation were assessed before and after the treatment. For creation of LLLT efficacy algorithm we used discriminate analysis. RESULTS: In patients of the 1st group we indicated statistically significant decrease of MAR-test by an average of 19% immediately after the course of procedures, and by 33% within two months after the end of the treatment, at its initial level 60% or lower. LLLT contributed to improvement of the semen fertile properties, pregnancy developed in the natural reproductive cycle in 19% of couples. We developed math model for prediction the efficacy of LLLT in infrared spectrum of autoimmune male infertility. CONCLUSION: LLLT in infrared spectrum of male autoimmune infertility leads to MAR-test value decrease at its initial level less than 60%; improves sperm fertile properties. It is appropriate to use before LLLT predictive algorithm of its efficacy developed by us.

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Elevated level of antisperm antibodies as a risk factor for unfavorable pregnancy outcome after use of assisted reproductive technology

Cited by 3 publications

References 13 publications

MАR-test and Spermiological Research Indices

MАR-test and Spermiological Research Indices

Our experience of application of low-level laser therapy in red spectrum in male idiopathic secretory infertility

Male autoimmune infertility: analysis of results and prediction of efficacy of low-level laser therapy in infrared spectrum

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