Elevated lactate dehydrogenase activity and increased cardiovascular mortality in the arsenic-endemic areas of southwestern Taiwan

Liao, Yu-Sheng; Chen, Chien-Jen; Li, Wan-Fen; Hsu, Ling‐I; Tsai, Li-Yu; Huang, Yeou‐Lih; Sun, Chien-Wen; Chen, Wei-Jen; Wang, Shuli

doi:10.1016/j.taap.2012.04.028

Cited by 26 publications

(21 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…31 In the present study, LDH level in STZ-induced diabetic mice was significantly higher as compared to the control animals, as also reported earlier. 32 This elevated LDH level, observed in the experimental diabetic animals may be associated with impaired insulin secretion.…”

Section: Effects Of Pyrroloquinoline Quinone and Vitamin C On Diabetesupporting

confidence: 90%

Effects of Pyrroloquinoline Quinone and Vitamin C on Diabetes Associated Cardiac Oxidative Damages and Hyperlipidemia in Mice: Biochemical and Histopathological Study

Kumar¹,

Kar²

2017

MOJBB

View full text Add to dashboard Cite

Enhanced hyperglycemia is associated with oxidative stress and hyperlipidemia that is also responsible for an increased risk factor for diabetes associated cardiovascular problems. As pyrroloquinoline quinone (PQQ) is a known antioxidative agent, the primary aim of this study was to explore the hitherto unknown potential of PQQ in regulating STZ-induced oxidative damages in heart and associated cardiovascular problems. Healthy male mice were divided into seven groups such as normoglycemic; PQQ treated control; STZ-treated (150mg/kg); STZ+PQQ treated (5, 10 and 20mg/ kg, respectively); and STZ+Vit. C treated (50mg/kg). At the end of the experiment( after 15 days of treatment), animals were sacrificed and markers of oxidative stress, various antioxidants, lipid profiles, alterations in insulin, lactate dehydrogenase (LDH), relative risk value (RR-value), atherogenic index (AI) and cardiac tissue histology were evaluated. STZ -treated animals not only developed oxidative stress as indicated by an increase in lipid peroxidation (LPO), lipid hydroperoxide (LOOH), LDH, RR-value and AI but also by a decrease in the levels of insulin, high density lipoprotein (HDL-C), superoxide dismutase, catalase, glutathione peroxidase and reduced glutathione. Following the administration of PQQ, particularly at 20mg/kg in diabetic animals, all these adverse effects were ameliorated with a decrease in LPO, LOOH, LDH and different lipids; with a parallel increase in cellular antioxidants, HDL-C and insulin level, suggesting cardioprotective effects of the test drug. Better effects were observed, as compared to that of Vit. C. Our study reveals that PQQ may have better ameliorating potential than Vit. C in regulation of the cardiovascular problems in diabetic patients.Keywords: diabetes mellitus, pyrroloquinoline quinine, vitamin-C, heart, lactate dehydrogenase, insulin, antioxidative agents MOJ Bioequivalence & Bioavailability Research ArticleOpen Access Effects of pyrroloquinoline quinone and vitamin C on diabetes associated cardiac oxidative damages and hyperlipidemia in mice: biochemical and histopathological study 202Copyright: ©2017 Kumar et al. studies have shown that PQQ can protect against several types of oxidative damages and irradiation injury. Recently, workers found not only the involvement of ROS in the pathogenesis of CVDs, but also suggested the use of antioxidants which play a major role in reducing the oxidative stress by scavenging the excess free radicals. 8,9 In recent years several compounds with antioxidant properties have been found to be beneficial and may protect or restore physiological function in diabetes associated CVDs, mainly plant based compounds have been investigated in details. 12 However, the recently known PQQ has not been tried with respect to its cardio-protective potential in diabetes, if any. An attempt has now been made to evaluate its role in the diabetes-induced CVDs and associated oxidative damage in heart. Citation Materials and methods AnimalsSwiss albino male mice, 7-8 weeks old...

show abstract

Section: Effects Of Pyrroloquinoline Quinone and Vitamin C On Diabetesupporting

confidence: 90%

Effects of Pyrroloquinoline Quinone and Vitamin C on Diabetes Associated Cardiac Oxidative Damages and Hyperlipidemia in Mice: Biochemical and Histopathological Study

Kumar¹,

Kar²

2017

MOJBB

View full text Add to dashboard Cite

show abstract

“…Twelve studies were conducted in high arsenic exposure areas of Taiwan (5), Bangladesh (3), Chile (1), Inner Mongolia (2) and Pakistan (1), and six studies were conducted in low to moderate arsenic exposure areas in the U.S. (3), Japan (1), Slovakia (1), and Spain (1). Of 12 cohort studies, six used internal comparisons [27, 28••, 29•, 30, 31•, 33] and six used external comparisons [32•, 34, 37, 42–44]. Of the cohort studies with internal comparisons, four were prospective [27, 28••, 29•, 33] and two were retrospective [30, 31•].…”

Section: Resultsmentioning

confidence: 99%

“…Of 12 cohort studies, six used internal comparisons [27, 28••, 29•, 30, 31•, 33] and six used external comparisons [32•, 34, 37, 42–44]. Of the cohort studies with internal comparisons, four were prospective [27, 28••, 29•, 33] and two were retrospective [30, 31•]. The remaining six studies used case control [35, 39, 40] or cross-sectional designs [24, 36, 38, 41].…”

Section: Resultsmentioning

confidence: 99%

“…Most studies assessed arsenic exposure using indirect measures (e.g., living in high arsenic areas) [34, 37, 42, 44] or using environmental measures, such as arsenic in drinking water at the region/county/zip code/municipal/village level [24, 27, 31•, 32•, 36], at the household/individual level [28••, 29•, 30, 33, 38, 41], or in air [43]. Two of the studies measuring arsenic in drinking water calculated an arsenic exposure index accounting for duration of water consumption [24, 27].…”

Section: Resultsmentioning

confidence: 99%

“…Available measures of association (e.g., odds ratios, prevalence ratios, hazard ratios, rate ratios, standardized mortality ratios) and their standard errors or 95 % confidence intervals (CI) were abstracted [8, 27–33] or derived [34–44] using the data reported in the publications [45]. Results presented separately for males and females were combined within each study.…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Arsenic Exposure and Cardiovascular Disease:An Updated Systematic Review

Moon

Güallar

Navas‐Acien

2012

Curr Atheroscler Rep

305

145

View full text Add to dashboard Cite

In epidemiologic studies, high-chronic arsenic exposure has been associated with cardiovascular disease, despite methodological limitations. At low-moderate arsenic levels, the evidence was inconclusive. Here, we update a previous systematic review (Am J Epidemiol 2005;162: 1037–49) examining the association between arsenic exposure and cardiovascular disease. Eighteen studies published since 2005 were combined with 13 studies from the previous review. We calculated pooled relative risks by comparing the highest versus the lowest exposure category across studies. For high exposure (arsenic in drinking water > 50 μg/L), the pooled relative risks (95 % confidence interval) for cardiovascular disease, coronary heart disease, stroke, and peripheral arterial disease were 1.32 (95 % CI: 1.05–1.67), 1.89 (95 % CI: 1.33–2.69), 1.08 (95 % CI: 0.98–1.19), and 2.17 (95 % CI: 1.47–3.20), respectively. At low-moderate arsenic levels, the evidence was inconclusive. Our review strengthens the evidence for a causal association between high-chronic arsenic exposure and clinical cardiovascular endpoints. Additional high quality studies are needed at low-moderate arsenic levels.

show abstract