Arsenic Exposure and Lifestyle-Related Diseases

Xu, Yuanyuan; Fu, Jingqi; Hou, Yongyong; Pi, Jingbo

doi:10.1007/978-981-13-2565-6_6

Cited by 5 publications

(2 citation statements)

References 223 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Exposure to Cd can cause renal dysfunction, osteoporosis, and cancer [3]. Long-term exposure to As in the human body can lead to toxic effects such as skin lesions, keratosis, diabetes, and various types of cancer [4,5]. Unfortunately, human activities, such as the application of agricultural inputs, including fertilizers, herbicides, and insecticides, as well as metal mining and smelting, industrial activities, and irrigation with contaminated groundwater, exacerbate the accumulation of Cd and As in the soil [2,6].…”

Section: Introductionmentioning

confidence: 99%

Evaluating Water Management Efficiency in Regulating Cadmium and Arsenic Accumulation in Rice in Typical Japonica Paddy Soils at Varied pH Levels

Wu,

Lin,

et al. 2024

Agriculture

View full text Add to dashboard Cite

There is growing concern regarding cadmium (Cd) exposure through rice consumption. Compared with alternate wetting and drying (AWD), continuous flooding (CF) is usually considered as an effective approach for reducing Cd enrichment in rice but increases the risk of pollution from arsenic (As). In this study, the field trial was conducted to investigate remediation effects of two water management (CF and AWD) techniques on Cd pollution in rice in typical japonica rice cultivation areas with varied soil pH levels. The results indicate that soil pH was a crucial factor in regulating CF-mediated Cd/As accumulation and migration in rice plants, and grains at all stages of rice growth. In acidic fields, compared with AWD, the use of CF reduced the accumulation of Cd in plants during the tillering stage; CF during the milk stage promotes the risk of contamination of Cd in rice grains and any form of As in plants and inhibits the content of any forms of As in grains. During the mature stage, CF reduced the levels of Cd in the plants and grains while promoting the accumulation of As(V) and total As(T-As) in plants and As(III) in grains. In alkaline fields, compared with AWD, CF during the tillering stage promoted the accumulation of various forms of As in plants. During the milk stage, CF increased and decreased the Cd content in plants and grains, respectively, and reduced the accumulation of T-As in plants and As(III) in grains; during the mature stage, CF promoted the accumulation of Cd in plants and grains, induced the accumulation of T-As plants, and inhibited the accumulation of any form of As in grains. From the perspective of food safety, the impact of CF conditions on the accumulation of Cd and As in rice from acidic fields exhibited a pattern of reduction in Cd and increase in As during the maturity period, as compared to that on the AWD. Conversely, CF increased the Cd risk while simultaneously reducing the As accumulation in rice grains to a safe level in alkaline fields. CF is not recommended as a remediation strategy for Cd pollution in rice in low Cd pollution areas, but it can be considered as a potential strategy for As pollution remediation in rice in alkaline fields with low Cd pollution.

show abstract

Section: Introductionmentioning

confidence: 99%

Evaluating Water Management Efficiency in Regulating Cadmium and Arsenic Accumulation in Rice in Typical Japonica Paddy Soils at Varied pH Levels

Wu,

Lin,

et al. 2024

Agriculture

View full text Add to dashboard Cite

show abstract

“…There are two forms of iAs, trivalent and pentavalent arsenic, with trivalent arsenic being the most toxic form 4 . iAs has been linked to the etiology of many chronic diseases, including cancer, chronic respiratory disease, and cardiovascular disease (CVD) [5][6][7][8][9][10][11][12][13] . iAs has been linked to many forms of CVD that include hypertension, atherosclerosis, coronary heart disease, and stroke 14 .…”

Section: Introductionmentioning

confidence: 99%

Prenatal Arsenite Exposure Alters Maternal Cardiac Remodeling During Late Pregnancy

Taube,

Kabir,

Ebenebe

et al. 2023

Preprint

View full text Add to dashboard Cite

Exposure to inorganic arsenic through drinking water is widespread and has been linked to many chronic diseases, including cardiovascular disease. Arsenic exposure has been shown to alter hypertrophic signaling in the adult heart, as well as in-utero offspring development. However, the effect of arsenic on maternal cardiac remodeling during pregnancy has not been studied. As such, there is a need to understand how environmental exposure contributes to adverse pregnancy-related cardiovascular events. This study seeks to understand the impact of trivalent inorganic arsenic exposure during gestation on maternal cardiac remodeling in late pregnancy, as well as offspring outcomes. C57BL/6J mice were exposed to 0 (control), 100 or 1000 µg/L sodium arsenite (NaAsO2) beginning at embryonic day (E) 2.5 and continuing through E17.5. Maternal heart function and size were assessed via transthoracic echocardiography, gravimetric measurement, and histology. Transcript levels of hypertrophic markers were probed via qRT-PCR and confirmed by western blot. Offspring outcomes were assessed through echocardiography and gravimetric measurement. We found that exposure to 1000 µg/L iAs abrogated normal physiologic growth of the maternal heart during late pregnancy and reduced transcript levels of estrogen receptor alpha (ERα), progesterone receptor membrane component 1 (Pgrmc1) and progesterone receptor membrane component 2 (Pgrmc2). Both 100 and 1000 µg/L iAs also reduced transcription of protein kinase B (Akt) and atrial natriuretic peptide (ANP). Akt protein expression was also significantly reduced after 1000 µg/L iAs exposure in the maternal heart with no change in activating phosphorylation. This significant abrogation of maternal cardiac hypertrophy suggests that arsenic exposure during pregnancy can potentially contribute to cardiovascular disease. Taken together, our findings further underscore the importance of reducing arsenic exposure during pregnancy and indicate that more research is needed to assess the impact of arsenic and other environmental exposures on the maternal heart and adverse pregnancy events.

show abstract