Elevated Intraocular Pressure in Patients Undergoing Penetrating Keratoplasty and Descemet Stripping Endothelial Keratoplasty

Sandhu, Sartaj; Petsoglou, Constantinos; Grigg, John; Veillard, Anne-Sophie

doi:10.1097/ijg.0000000000000251

Cited by 20 publications

(15 citation statements)

References 32 publications

(40 reference statements)

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“…Glaucoma is one of the most common complications after corneal transplantation and the degree of damage is generally linked to the surgical method, particularly PKP, DSEK and Boston artificial corneal transplantation ( 19 ). The postoperative incidence was 33.33%, which was consistent with that of previous studies ( 13 , 19 , 20 ). The incidence of postoperative glaucoma in the DSEK group of the present study was 34.21%, which was higher than that in previous studies, which reported incidences of 0-15% ( 21 , 22 ), but was similar to that in other studies that indicated that the incidence of glaucoma after DSEK may be as high as 35-39% ( 23 , 24 ).…”

Section: Discussionsupporting

confidence: 92%

“…Secondary glaucoma was defined as follows: IOP or estimated IOP ≥24 mmHg and requires intervention with IOP-lowering medication, postoperative IOP is 10 mmHg higher than the preoperative IOP, or the IOP cannot be controlled by drugs and surgical treatment is required (11)(12)(13)(14). Primary transplant failure refers to transparent persistent irreversible corneal edema after surgery (15).…”

Section: Pkpmentioning

confidence: 99%

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Comparative observation of the efficacy of simplified Descemet stripping endothelial keratoplasty and penetrating keratoplasty in treating bullous keratopathy

et al. 2020

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The aim of the present study was to compare the clinical efficacy between simplified Descemet stripping endothelial keratoplasty (DSEK) and penetrating keratoplasty (PKP) in the treatment of patients with bullous keratopathy (BK). A cohort of 65 patients (65 eyes) with BK recruited between December 2002 and June 2018 was divided into two groups according to the treatment they received: The simplified DSEK group (n=38) and the PKP group (n=27). The best-corrected visual acuity (BCVA) during the follow-up at 1, 3, 6 and 12 months and postoperative complications were all recorded. Furthermore, the graft survival rate after 1 year was recorded. The mean BCVA in the simplified DSEK group was significantly better than that in the PKP group after 1, 3, 6 and 12 months (P<0.05). Furthermore, the 1-year graft survival rate in the simplified DSEK group (91.2%) was significantly higher than that in the PKP group (70.4%; P= 0.039). A total of 13 eyes (34.21%) in the simplified DSEK group and 11 eyes (40.74%) in the PKP group were diagnosed with glaucoma; there was no significant difference between the rate of glaucoma diagnosis between the two groups (P=0.591). Graft rejection was observed in 5 eyes (13.16%) of the simplified DSEK group and 8 eyes (29.63%) of the PKP group and the rate of graft rejection did not differ significantly between the groups (P= 0.279). Graft infection occurred in 1 eye (2.63%) in the simplified DSEK group and 6 eyes (22.22%) in the PKP group. Simplified DSEK achieved better visual acuity and longer graft survival rates than PKP. The incidence of postoperative secondary glaucoma, graft rejection and graft infection after simplified DSEK was lower than that in the PKP group, but only the incidence of graft infection was significantly different.

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Section: Discussionsupporting

confidence: 92%

Section: Pkpmentioning

confidence: 99%

Comparative observation of the efficacy of simplified Descemet stripping endothelial keratoplasty and penetrating keratoplasty in treating bullous keratopathy

et al. 2020

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“…However, many studies calculate the frequency of elevated IOP after keratoplasty by dividing the number of observed cases by the number of grafts performed during the study period. 1,9,13,14 Because many patients may not be followed long enough to note the onset of hypertony, such calculation methodology leads to an underestimation of true incidence. We used a survival analysis to provide more accurate assessments.…”

Section: Discussionmentioning

confidence: 99%

Incidence of Intraocular Pressure Elevation and Glaucoma after Lamellar versus Full-Thickness Penetrating Keratoplasty

2016

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“…Reduktion der Steroidtherapie unter Kontrolle gebracht werden [67]. Generell wird das Risiko nach DMEK für Augendruckanstiege, Glaukominduktionen oder -exazerbationen deutlich niedriger beziffert als nach DS(A)EK oder PKP [67,68]. Darüber hinaus ist aufgrund der weitaus selteneren immunologischen Abstoßung bei DMEK von einer kumulativ geringeren "Steroidlast" auszugehen als bei den beiden anderen kornealen Transplantationsverfahren.…”

Section: Seltenere Komplikationenunclassified

Descemet-Membran-Endothelkeratoplastik (DMEK)

Luft

Dirisamer

Priglinger

2016

Klin Monatsbl Augenheilkd

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Descemet membrane endothelial keratoplasty (DMEK) is the gold standard for the treatment of corneal endothelial disease, first and foremost Fuchs' endothelial dystrophy. Superior visual rehabilitation as well as lower and decreasing complication rates can be obtained with DMEK than with Descemet stripping automated endothelial keratoplasty (DSAEK) - still the most commonly performed type of posterior lamellar keratoplasty. Recent advancements in the DMEK method include the establishment of a standardised and reproducible surgical "no touch" technique and the emerging role of eye banks, which are able to prepare convenient pre-cut DMEK grafts. These developments pave the way for increasing numbers of corneal surgeons to add DMEK to their armamentarium, despite the more challenging nature of this procedure. However, a review of the current literature shows that this fascinating technique still offers certain challenges, which need to be further addressed. For example, graft detachment remains the most commonly encountered complication after DMEK. A plethora of prospective-randomised studies is required to further endorse the evident superiority of DMEK over alternative types of lamellar keratoplasty and to help propagate the practice of this fascinating technique.

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Elevated Intraocular Pressure in Patients Undergoing Penetrating Keratoplasty and Descemet Stripping Endothelial Keratoplasty

Cited by 20 publications

References 32 publications

Comparative observation of the efficacy of simplified Descemet stripping endothelial keratoplasty and penetrating keratoplasty in treating bullous keratopathy

Comparative observation of the efficacy of simplified Descemet stripping endothelial keratoplasty and penetrating keratoplasty in treating bullous keratopathy

Incidence of Intraocular Pressure Elevation and Glaucoma after Lamellar versus Full-Thickness Penetrating Keratoplasty

Descemet-Membran-Endothelkeratoplastik (DMEK)

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