Elevated International Normalized Ratio values in a patient receiving warfarin and ceftaroline

Farhat, Nada M; Hutchinson, Lisa S.; Peters, Michael A.

doi:10.2146/ajhp140897

Cited by 7 publications

(1 citation statement)

References 16 publications

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“…Additionally, transient blood dyscrasias have been described in recent case reports including agranulocytosis in both an adolescent and an adult [42, 43], and a probable interaction between ceftaroline and warfarin yielding a significantly supratherapeutic INR in an adult patient [44]. A 10–20% incidence of neutropenia with prolonged use has also been reported in retrospective reviews of adult patients [45, 46].…”

Section: Introductionmentioning

confidence: 99%

Use of Ceftaroline Fosamil in Children: Review of Current Knowledge and its Application

2016

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Ceftaroline is a novel cephalosporin recently approved in children for treatment of acute bacterial skin and soft tissue infections and community-acquired bacterial pneumonia (CABP) caused by methicillin-resistant Staphylococcus aureus, Streptococcus pneumoniae and other susceptible bacteria. With a favorable tolerability profile and efficacy proven in pediatric patients and excellent in vitro activity against resistant Gram-positive and Gram-negative bacteria, ceftaroline may serve as a therapeutic option for polymicrobial infections, CABP caused by penicillin- and ceftriaxone-resistant S. pneumoniae and resistant Gram-positive infections that fail first-line antimicrobial agents. However, limited data are available on tolerability in neonates and infants younger than 2 months of age, and on pharmacokinetic characteristics in children with chronic medical conditions and those with invasive, complicated infections. In this review, the microbiological profile of ceftaroline, its mechanism of action, and pharmacokinetic profile will be presented. Additionally, clinical evidence for use in pediatric patients and proposed place in therapy is discussed.

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