Beta-Lactam Antibiotics

Danziger, Larry H.; Horn, K

doi:10.1007/978-3-319-72416-4_1

Cited by 4 publications

(5 citation statements)

References 301 publications

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“…Oral anticoagulants Increased risk of haemorrhages [14,82] Probenecid Blockage of tubular secretion of penicillin G and increased levels of plasma concentrations of the drug; decrease the volume of distribution of penicillin [83] Methotrexate Penicillins may reduce renal secretion and result in increased systemic exposure [84] NSAIDs Increase in penicillin exposure [83] Aspirin, Furosemide, Indomethacin, Sulphonamides…”

Section: Penicillinsmentioning

confidence: 99%

“…The half-time of the penicillin may be increased due to competitive inhibition of tubular secretion [14,83,85,86] Cephalosporins Aminoglycosides and loop-diuretics Cephalosporins potentiate the nephrotoxic effects of aminoglycosides and loop-diuretics [18,87] Carbapenems Valproic acid Decrease in valproic acid serum level, liver injury [22,23,[25][26][27][28] Amikacin Lower serum level of both antibiotics [29] Monobactams Furosemide/Probenecid Moderately increase the systemic exposure of aztreonam [11] Fluoroquinolones NSAIDs Fluoroquinolones-convulsion-inducing effects remain unclear, have been suggested to antagonize the inhibitory effect of gamma-aminobutyric acid or active the excitatory N-methyl-D-aspartate receptors of brain neurons NSAIDs-some in vitro studies have shown that some NSAIDs may enhance the inhibitory effect of fluroquinolones on gamma-aminobutyric acid receptors [88,89]…”

Section: Penicillinsmentioning

confidence: 99%

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Antibiotic–Drug Interactions in the Intensive Care Unit: A Literature Review

Radkowski,

Derkaczew,

Mazuchowski

et al. 2024

Antibiotics

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Interactions between drugs are a common problem in Intensive Care Unit patients, as they mainly have a critical condition that often demands the administration of multiple drugs simultaneously. Antibiotics are among the most frequently used medications, as infectious diseases are often observed in ICU patients. In this review, the most important antibiotic–drug interactions, based on the pharmacokinetic and pharmacodynamic mechanisms, were gathered together and described. In particular, some of the most important interactions with main groups of antibacterial drugs were observed in patients simultaneously prescribed oral anticoagulants, NSAIDs, loop diuretics, and valproic acid. As a result, the activity of drugs can be increased or decreased, as dosage modification might be necessary. It should be noted that these crucial interactions can help predict and avoid negative consequences, leading to better patient recovery. Moreover, since there are other factors, such as fluid therapy or albumins, which may also modify the effectiveness of antibacterial therapy, it is important for anaesthesiologists to be aware of them.

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Section: Penicillinsmentioning

confidence: 99%

Section: Penicillinsmentioning

confidence: 99%

Antibiotic–Drug Interactions in the Intensive Care Unit: A Literature Review

Radkowski,

Derkaczew,

Mazuchowski

et al. 2024

Antibiotics

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show abstract

“…(S)-2-Amino-3-(((S)-1-carboxy-2-(((S)-1-carboxy-2-(1Himidazol-4-yl)ethyl)amino)ethyl)amino)propanoic Acid (10). His-substituted AMA analog 10 was synthesized according to the above general procedure using Trt-D-His-substituted Wang resin.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

“…Although these drug combinations are effective, their spectrum of activity is limited to SBL-producing bacteria. This fact leaves the growing clinical challenge of MBLs unmet, indicating the need for MBL-targeted therapeutics. − …”

Section: Introductionmentioning

confidence: 99%

Three-Dimensional Structure and Optimization of the Metallo-β-Lactamase Inhibitor Aspergillomarasmine A

et al. 2022

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The aminopolycarboxylic acid aspergillomarasmine A (AMA) is a natural Zn 2+ metallophore and inhibitor of metalloβ-lactamases (MBLs) which reverses β-lactam resistance. The first crystal structure of an AMA coordination complex is reported and reveals a pentadentate ligand with distorted octahedral geometry. We report the solid-phase synthesis of 23 novel analogs of AMA involving structural diversification of each subunit (L-Asp, L-APA1, and L-APA2). Inhibitory activity was evaluated in vitro using five strains of Escherichia coli producing globally prevalent MBLs. Further in vitro assessment was performed with purified recombinant enzymes and intracellular accumulation studies. Highly constrained structure−activity relationships were demonstrated, but three analogs revealed favorable characteristics where either Zn 2+ affinity or the binding mode to MBLs were improved. This study identifies compounds that can further be developed to produce more potent and broader-spectrum MBL inhibitors with improved pharmacodynamic/pharmacokinetic properties.

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“…Beta laktamase dapat meningkatkan porositas dari dinding sel bakteri sehingga dapat meningkatkan penetrasi aminoglikosida untuk mencapai ribosom bakteri. Pada penelitian retrospektif didapatkan bahwa kombinasi kedua antibiotik tersebut menghasilkan respon klinis yang lebih baik pada kelompok pasien neutropenia, bakteremia yang disebabkan Pseudomonas aeruginosa, namun berdasarkan penelitian meta analisis pemberian kedua antibiotik tersebut tidak sesuai jika diberikan sebagai terapi definitif infeksi bakteri gram negatif [24].…”

Section: Potensi Interaksi Obat Golongan Antibiotik Pada Pasien Pedia...unclassified

Interaksi Antibiotik Dengan Obat Lainnya Pada Pasien Pediatri : Sebuah Kajian Naratif

Atmaja,

Kurniawaty,

Kristariyanto

2022

jfki

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Peresepan obat antibiotik pada pasien pediatri umumnya disertai dengan obat-obatan yang digunakan untuk mengatasi gejala penyakit. Oleh karenanya tidak jarang didapati adanya interaksi antibitotik dengan obat lainnya yang bersifat minor, moderate maupun mayor. Kajian naratif ini merangkum kejadian interaksi antibiotik dengan obat lainnya dari beberapa penelitian yang bersumber dari Google scholar dengan kata kunci: interaksi AND antibiotik AND anak , antibiotic AND interaction AND pediatric AND Indonesia. Dari hasil penelusuran didapati interaksi antibiotik dengan obat lainnya pada berbagai tingkat interaksi, namun acuan yang seringkali digunakan untuk mengevaluasi potensi interaksi obat tersebut menggunakan acuan interaksi obat pada pasien dewasa. Hal tersebut menyebabkan prediksi interaksi yang berlebihan atau kurang dari yang seharusnya. Oleh karena itu masih ada kesempatan atau pandangan penelitian interaksi obat khusunya antibiotik pada golongan pasien pediatri

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Beta-Lactam Antibiotics

Cited by 4 publications

References 301 publications

Antibiotic–Drug Interactions in the Intensive Care Unit: A Literature Review

Antibiotic–Drug Interactions in the Intensive Care Unit: A Literature Review

Three-Dimensional Structure and Optimization of the Metallo-β-Lactamase Inhibitor Aspergillomarasmine A

Interaksi Antibiotik Dengan Obat Lainnya Pada Pasien Pediatri : Sebuah Kajian Naratif

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