Elevated HOTAIR expression associated with cisplatin resistance in non-small cell lung cancer patients

Liu, Mingyue; Li, Xiqing; Gao, Tianhui; Cui, Yao; Ma, Ning; Zhou, Yun; Zhang, Guojun

doi:10.21037/jtd.2016.11.75

Cited by 79 publications

(70 citation statements)

References 35 publications

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“…Another study showed that HOTAIR expression was higher in tissues of drugresistant patients with NSCLC than those of non-drug-resistant patients. HOTAIR expression was elevated in cisplatin-resistant cell strains (A549/CDDP), and reduction of HOTAIR increased the sensitivity of A549/ CDDP cells to cisplatin [32]. Functions and mechanisms of HOTAIR-mediated gene silencing, regulation of chromatin dynamics, and association between HOTAIR and miRNAs in human cancers.…”

Section: Waf1/cip1mentioning

confidence: 99%

HOTAIR: An Oncogenic Long Non-Coding RNA in Human Cancer

Tang

Hann

2018

Cell Physiol Biochem

213

135

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Long non-coding RNAs (LncRNAs) represent a novel class of noncoding RNAs that are longer than 200 nucleotides without protein-coding potential and function as novel master regulators in various human diseases, including cancer. Accumulating evidence shows that lncRNAs are dysregulated and implicated in various aspects of cellular homeostasis, such as proliferation, apoptosis, mobility, invasion, metastasis, chromatin remodeling, gene transcription, and post-transcriptional processing. However, the mechanisms by which lncRNAs regulate various biological functions in human diseases have yet to be determined. HOX antisense intergenic RNA (HOTAIR) is a recently discovered lncRNA and plays a critical role in various areas of cancer, such as proliferation, survival, migration, drug resistance, and genomic stability. In this review, we briefly introduce the concept, identification, and biological functions of HOTAIR. We then describe the involvement of HOTAIR that has been associated with tumorigenesis, growth, invasion, cancer stem cell differentiation, metastasis, and drug resistance in cancer. We also discuss emerging insights into the role of HOTAIR as potential biomarkers and therapeutic targets for novel treatment paradigms in cancer.

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Section: Waf1/cip1mentioning

confidence: 99%

HOTAIR: An Oncogenic Long Non-Coding RNA in Human Cancer

Tang

Hann

2018

Cell Physiol Biochem

213

135

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“…Tumor cell stemness is another important phenotype related to drug resistance, which indicates a difficult cell death induced by DDP and a significant contribution to tumor development and metastasis. HOTAIR could promote DDP resistance in NSCLC cells by upregulating Klf4 which plays an important role in maintaining cell stemness (Liu et al, 2016).…”

Section: Upregulated Lncrnas In Nsclc Ddp Resistancementioning

confidence: 99%

Long Non-Coding RNA in Drug Resistance of Non-Small Cell Lung Cancer: A Mini Review

et al. 2019

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Lung cancer is one of main causes of cancer mortality and 83% of lung cancer cases are classified as non-small cell lung cancer (NSCLC). Patients with NSCLC usually have a poor prognosis and one of the leading causes is drug resistance. With the progress of drug therapy, the emergence and development of drug resistance affected the prognosis of patients severely. Accumulating evidence reveals that long non-coding RNAs (lncRNAs), as "dark matters" of the human genome, is of great significance to drug resistance in NSCLC. Herein, we review the role of lncRNAs in drug resistance in NSCLC.

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“…19 The expression of LncRNA HOTAIR was dramatically elevated in NSCLC drug-resistant tissues and cells, and HOTAIR contributed to the drug-resistance via upregulating Kif4. 20 In present study, we focused on the function and mechanism of lncRNA TATDN1 in NSCLC cisplatin resistance. As results showed that TATDN1 was obviously upregulated in DDP-tolerant NSCLC tissues and cell lines, and patients with low TATDN1 expression displayed a better long-term prognosis following DDP-treatment.…”

Section: Discussionmentioning

confidence: 99%

LncRNA TATDN1 contributes to the cisplatin resistance of non-small cell lung cancer through TATDN1/miR-451/TRIM66 axis

Wang

Shang

Feng

2018

Cancer Biology & Therapy

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Background: Chemoresistance has been considered to be a major obstacle for cancer therapy clinically. Long non-coding RNAs (LncRNAs) are asscociated with the development, prognosis and drug-resistance of non-small cell lung cancer (NSCLC). Whereas, the regulatory mechanism of lncRNA TATDN1 in the cisplatin resistance of NSCLC is still not clear. Methods: The expression of TATDN1, miR-451 and TRIM66 in NSCLC tissues and cell lines were detected by qRT-PCR or western blot. Immunohistochemistry (IHC) assay was performed for the detection of TATDN1 expression profile. 88 patients who underwent cisplatin treatment were followed up to 60-months for the analysis of survival rate. MTT and Flow cytometry analysis were performed for the assessment of cell survival rate, proliferation and apoptosis. Bioinformatics, Dual-Luciferase reporter were employed to analyze the interaction among TATDN1, miR-451 and TRIM66. Xenograft tumor model was constructed to verify the role of TATDN1 in NSCLC treated with cisplatin (DDP) in vivo. Results: TATDN1 and TRIM66 was significantly upregulated while miR-451 was downregulated in NSCLC tissues and cell lines, especially in DDP-resistant tumor tissues and cells. Survival rates of NSCLC patients with low TATDN1 expression were improved following DDP chemotherapy. TATDN1 upregulated TRIM66 expression via sponge for miR-451. Moreover, TATDN1 knockdown improved DDP-sensitivity in NSCLC patients by regulation of miR-451/TRIM66 axis. Finally, knockdown of TATDN1 improved the sensitivity of NSCLC to DDP in vivo. Conclusions: TATDN1 enhanced the DDP-tolerance of NSCLC cells by upregulating TRIM66 expression via sponging miR-451, hinting a novel regulatory pathway of chemoresistance in DDP-tolerant NSCLC cells and providing a potential therapeutic target for NSCLC patients with DDP-reistance. ARTICLE HISTORY

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Elevated HOTAIR expression associated with cisplatin resistance in non-small cell lung cancer patients

Cited by 79 publications

References 35 publications

HOTAIR: An Oncogenic Long Non-Coding RNA in Human Cancer

HOTAIR: An Oncogenic Long Non-Coding RNA in Human Cancer

Long Non-Coding RNA in Drug Resistance of Non-Small Cell Lung Cancer: A Mini Review

LncRNA TATDN1 contributes to the cisplatin resistance of non-small cell lung cancer through TATDN1/miR-451/TRIM66 axis

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