Elevated frequencies of micronuclei in pregnant women with type 1 diabetes mellitus and in their newborns

Sirt3-dependent deacetylation of SOD2 plays a protective role against oxidative stress in oocytes from diabetic mice

“…This observation is consistent with previous findings that hyperglycemia can directly induce ROS generation. 12 ROS produced primarily in the mitochondria as a byproduct of metabolism, and mitochondria are also a vulnerable target of ROS-induced oxidative damage. 28,34 Meanwhile, other reports also showed that ROS mediates oxidative damage that may lead to mitochondrial dysfunction in mammalian oocytes.…”

“…Over-production of ROS induces oxidative damage to the cells, including membrane lipids, proteins, as well as DNA. 11,12 Notably, maternal hyperglycemia is known to increase oxidative stress in diverse tissues. 13 Moreover, such oxidative damage has been shown to influence the ability of oocyte maturation, fertilization, and pregnancy rates in mice as well as in humans.…”

Nuclear abnormalities in buccal mucosa cells of patients with type I and II diabetes treated with folic acid

“…The results of some studies of patients with type II DM have shown a higher frequency of MN in buccal mucosa samples from patients with diabetes in comparison with that of the control group [8,10,12,15,28]. Furthermore, Cinkilic et al [35] found no significant difference in the frequency of MN in peripheral blood lymphocytes in patients with type I DM and those of healthy controls, whereas Witczak et al [64] described differences between MN frequencies in lymphocytes from mothers with type I DM at the time of delivery and those of mothers without DM. The mothers with diabetes and their newborns had higher frequencies of MN, with an increased MN frequency in cord blood lymphocytes in comparison with that of newborns from mothers without diabetes [64].…”

“…Furthermore, Cinkilic et al [35] found no significant difference in the frequency of MN in peripheral blood lymphocytes in patients with type I DM and those of healthy controls, whereas Witczak et al [64] described differences between MN frequencies in lymphocytes from mothers with type I DM at the time of delivery and those of mothers without DM. The mothers with diabetes and their newborns had higher frequencies of MN, with an increased MN frequency in cord blood lymphocytes in comparison with that of newborns from mothers without diabetes [64]. A similar result was described for preterm newborn peripheral blood erythrocytes [65], which demonstrated that the frequency of MN was increased in preterm newborns born to mothers with pathologies that involved overproduction of free radicals.…”

Structure of Relations Between the Frequency of Micronuclei in Peripheral Blood Lymphocytes and Age, Gender, Smoking Habits and Socio-Demographic Factors in South-East Region of Serbia

“…From new-borns, blood was taken from umbilical cord after birth at the Clinic for Gynaecology and Obstetrics, Clinical Centre Nis, Serbia. New-borns from healthy mothers that fulfilled the above-mentioned criteria, without gestational diabetes [34], natural conception, regular pregnancy, without infections during pregnancy or consumption of antibiotics during pregnancy, term labour with regular duration, vaginal delivery, and Apgar score 9 or 10, were included in the study. New-borns whose mothers had prolonged labour or caesarean section were excluded from the study.…”