2017
DOI: 10.1080/15384101.2017.1320004
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Abstract: Maternal diabetes has been demonstrated to adversely affect oocyte quality in mouse oocytes. However, the potential molecular mechanisms are poorly understood. Here, we established a type I diabetic mouse model and detected the increased reactive oxygen species (ROS) levels and decreased Sirt3 expression in oocytes from diabetic mice. Furthermore, we found that forced expression of Sirt3 in diabetic oocytes significantly attenuates such an excessive production of ROS. The acetylation status of lysine 68 of sup… Show more

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Cited by 60 publications
(36 citation statements)
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“…On the other hand, its de‐acetylase activity can also be regulated by post‐translational modifications (Liu et al , ). The mitochondrial targets of SIRT3 include superoxide dismutase 2 (SOD2) and isocitrate dehydrogenase 2 (IDH2), both of which are closely related to ROS generation and leukaemogenesis (Ward et al , ; Yu et al , ; Girerd et al , ; Liu et al , ). Given that sophisticated regulation of ROS production is required for the maintenance of leukaemic blasts and stem cells, we investigated the regulatory mechanism of mitochondrial ROS in chemoresistance of AML, which may not only contribute to a better understanding of SIRT3 in haematopoietic malignancies, but also provide the rationale of targeting SIRT3 to improve chemotherapy outcome.…”
mentioning
confidence: 99%
“…On the other hand, its de‐acetylase activity can also be regulated by post‐translational modifications (Liu et al , ). The mitochondrial targets of SIRT3 include superoxide dismutase 2 (SOD2) and isocitrate dehydrogenase 2 (IDH2), both of which are closely related to ROS generation and leukaemogenesis (Ward et al , ; Yu et al , ; Girerd et al , ; Liu et al , ). Given that sophisticated regulation of ROS production is required for the maintenance of leukaemic blasts and stem cells, we investigated the regulatory mechanism of mitochondrial ROS in chemoresistance of AML, which may not only contribute to a better understanding of SIRT3 in haematopoietic malignancies, but also provide the rationale of targeting SIRT3 to improve chemotherapy outcome.…”
mentioning
confidence: 99%
“…The significant role of SIRT3 activity in ROS detoxification was shown in studies with oxygen and glucose deprivation‐induced neuronal damage (Dai et al, ), oxidative stress in type I diabetic model (Liu et al, ), heart ischemia‐induced damage (Parodi‐Rullan, Chapa‐Dubocq, Rullan, Jang, & Javadov, ), intracerebral hemorrhage in diabetic animals (Zheng et al, ), or protective mechanisms in adaptive responses of neurons to physiological challenges and resistance to degeneration (Cheng et al, ). Our data show that SIRT3KO mice exhibit increased ROS levels when compared to WT animals with no change after NMN administration.…”
Section: Discussionmentioning
confidence: 97%
“…Sirtuin3(SIRT3)is a class III histone deacetylase (HDAC) and a part of sirtuin gene family predominantly located in mitochondria, which expresses in a variety of tissues and is highly expressed in the brain . Recent studies showed that SIRT3 exhibits mighty deacetylase activity and is the key regulator in organ protection under many pathologic states including inflammatory and oxidative stress, acting pivotal roles in development and progression of metabolic diseases including diabetes, neurodegenerative disorders, and other diseases . Honokiol (HNK), [2‐(4‐hydroxy‐3‐prop‐2‐enyl‐phenyl)‐4‐prop‐2‐enyl‐phenol], is a bioactive compound obtained from Magnolia grandiflora which possesses multiple properties including anti‐tumor, anti‐arrhythmic, anti‐thrombocytic, anti‐inflammatory, anti‐angiogenesis, anxiolytic, anti‐oxidative activities in vivo and in vitro .…”
Section: Introductionmentioning
confidence: 99%
“…11 Recent studies showed that SIRT3 exhibits mighty deacetylase activity and is the key regulator in organ protection under many pathologic states including inflammatory and oxidative stress, acting pivotal roles in development and progression of metabolic diseases including diabetes, neurodegenerative disorders, and other diseases. [12][13][14][15] Honokiol (HNK), [2-(4- anti-oxidative activities in vivo and in vitro. [16][17][18][19][20][21] As a potent reactive oxygen species (ROS) scavenger, it is also reported that HNK can enhance the overexpression of SIRT3 to improve antioxidant activity and mitochondrial energy regulation thereby reducing the levels of Aβ and sAPPβ in Chinese Hamster Ovarian (CHO) cells.…”
mentioning
confidence: 99%