Elevated Factor VIII Levels and Shortened APTT in Recurrent Abortions

Ali, Aysha; Mohan, Pushpavalli; Kareem, Hana H.; Muhammed, Mahsheena Kalpaka

doi:10.7860/jcdr/2016/17841.7080

Cited by 11 publications

(9 citation statements)

References 9 publications

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“…On the other hand, we evaluated both coagulation and fibrinolysis markers, such as fibrinogen, FVIII and PAI-1, demonstrating higher concentrations of these parameters in women with history of RPL, in keeping with data from global assays. Of interest, our results provided evidence for a significant correlation between FVIII levels and CAT parameters in patients, but not in controls, thus underling the role of this factor in maintaining a thrombophilic condition in RPL women outside of pregnancy, as previously reported [8,22].…”

Section: Discussionsupporting

confidence: 73%

“…An adequate balance between coagulation and fibrinolysis is mandatory to avoid an excessive fibrin accumulation in placental vessel and intervillous space, as well as a greater propensity to undergo partial or total occlusion of placental vessels by thrombus formation [7]. Data from clinical studies provided evidence for an association between increased factor VIII (FVIII) concentrations and recurrent abortion [8], as well as hypofibrinolysis, mainly related to high PAI-1 levels, is involved in unexplained early recurrent miscarriage [9]. Therefore, these parameters might be used in exploring a potential prothrombotic status in women suffered from RPL.…”

Section: Introductionmentioning

confidence: 99%

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Thrombin potential and traditional coagulation assay

Romagnuolo

Attanasio

Cozzolino

et al. 2018

Blood Coagulation &Amp; Fibrinolysis

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: An adequate hemostatic balance is mandatory to get successful pregnancy. Obstetric complications, such as recurrent pregnancy loss (RPL), might be due to an impairment of placental perfusion possibly related to an underlying prothrombotic status. In this study, we used the global coagulation assay, calibrated automated thrombography and traditional coagulation assay to search for a possible underlying hypercoagulable status in women with history of RPL compared with uneventful pregnancy women. Thrombin generation, Fibrinogen, factor VIII (FVIII), Plasminogen Activator Inhibitor-1 (PAI-1) and von Willebrand factor levels were analyzed in 92 not pregnant unexplained RPL and 64 uneventful pregnancy women. In RPL women, significantly higher fibrinogen, FVIII and PAI-1 levels, and thrombin generation with respect to those observed in uneventful pregnancy women were found. By dividing the study population into quartiles of endogenous thrombin potential (ETP), a lower percentage of RPL women than uneventful pregnancy women in the second quartile was observed, whereas a higher percentage of RPL in comparison with uneventful pregnancy women in the third and fourth quartile was found (P = 0.009). Accordingly, the cut-off ETP of 1222.1 nmol/l was chosen; ETP above cut-off concentration was associated with more than two-fold increased risk of RPL (P = 0.008), also after adjustment for traditional risk factors (P = 0.009). We provided evidence of an underlying alteration of vascular network related to increased coagulation components, and fibrinolysis inhibitor levels in healthy women with history RPL; therefore, calibrated automated thrombography global assay and testing for FVIII and PAI-1 would be advisable in clinical practice to evaluate the hypercoagulable status in RPL women planning future pregnancy.

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Section: Discussionsupporting

confidence: 73%

Section: Introductionmentioning

confidence: 99%

Thrombin potential and traditional coagulation assay

Romagnuolo

Attanasio

Cozzolino

et al. 2018

Blood Coagulation &Amp; Fibrinolysis

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“…APTT, a global coagulation test of clotting factor levels of the intrinsic system, has been widely used to search for lupus anticoagulants, and as a test of choice for dose-adjustment [ 26 ]. Additionally, APTT reflects both the common intrinsic pathways involved in the coagulation cascade; this makes it a particularly useful marker for thrombotic activity [ 27 ]. During the development of DVT venous stasis, blood coagulation and release of thromboplastin are interrupted [ 28 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Inhalation Anesthesia vs. Total Intravenous Anesthesia (TIVA) vs. Spinal-Epidural Anesthesia on Deep Vein Thrombosis After Total Knee Arthroplasty

Zhou

Liu

et al. 2018

Med Sci Monit

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BackgroundThe objective of the present study was to evaluate the varying efficacy of general anesthesia (GA), combined spinal-epidural anesthesia (CSEA), and total intravenous anesthesia (TIVA) on the occurrence of deep vein thrombosis (DVT) following total knee arthroplasty (TKA).Material/MethodsFrom July 2013 to May 2015, a total of 197 cases of patients who had undergone TKA treatment at either the Drum Tower Hospital or Nanjing General Hospital of Nanjing Military Command were recruited to participate in the study. The patients in the study were separated into 3 groups depending on the anesthesia approach received: the GA group, the CSEA group, and the TIVA group. The baseline characteristics and relative parameters of patients were monitored before and after surgery for analytic purposes. A 3-month follow-up after surgery was conducted to observe the rate of DVT occurrence and any DVT-related complications.ResultsThe TIVA group exhibited significant decreases in relation to the swallowing time reflex, extubation, and consciousness recovery in comparison to other groups in the study. Additionally, platelet count was significantly decreased and there was drastic extension of the activated partial thromboplastin time (APTT) in the CSEA group and the TIVA group. There were clear differences in the incidence of DVT and its complications among the 3 groups. The TIVA group displayed the lowest incidences of DVT and DVT-related complication during the study. Based on logistic regression analysis, the type of anesthesia was utilized as an independent correlative factor for the occurrence of DVT after surgery.ConclusionsThe results obtained during the study established a clinical basis for comparative analysis of various anesthesia methods. We found that, compared with GA and CSEA, patients undergoing TIVA had a reduced rate of risk in relation to the occurrence of DVT following TKA.

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“…reference plasma with known content of all the factors and factor VIII deficient plasma with factor level less than 1% activity must be available for the assay. 30 One part of test plasma and one part of factor VIII deficient plasma (Stago) and one part of APTT reagent (CK PREST, STAGO) are mixed then incubated at 37⁰C, in addition, one part of calcium chloride is added, then we note the time taken to clot. Abnormal system control plasma with a factor VIII level of 32-46% and normal system controls with factor VIII level of 87-121% are subjected to the test simultaneously with patient's sample.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of factor VIII value in normal women and whom encountered recurrent pregnancy loss: is there any significant difference?

Rez

Eldine

Alhalabi

2020

Int J Reprod Contracept Obstet Gynecol

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Background: Recurrent pregnancy loss (RPL) is a serious problem on the women, it defined as two or more consecutive pregnancy losses before the fetus has reached birth. The aim of this study is to evaluate the association between the elevation in the factor VIII and RPL. Because women who have thrombophilia have increased risk of fetal loss in most studies.Methods: A total 72 women were recruited in this case control study. They divided into two groups: the RPL group included 41 women with a history of recurrent pregnancy loss and the control group included 31 healthy women, who had at least one successful pregnancy and none of them had a history of fetal loss or complicated pregnancy.Results: A majority of the patients of this study didn't have a high level of factor VIII, 9 of 41 (22%) patients of RPL group in comparison with 21 of 32 (65,6%) of control group, that suffer from the increase rate of FVIII, this means that factor VIII doesn't effect on RPL.Conclusions: The present study showed that the serum elevation in the factor VIII is not significantly associated with RPL.

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Elevated Factor VIII Levels and Shortened APTT in Recurrent Abortions

Cited by 11 publications

References 9 publications

Thrombin potential and traditional coagulation assay

Thrombin potential and traditional coagulation assay

Effects of Inhalation Anesthesia vs. Total Intravenous Anesthesia (TIVA) vs. Spinal-Epidural Anesthesia on Deep Vein Thrombosis After Total Knee Arthroplasty

Evaluation of factor VIII value in normal women and whom encountered recurrent pregnancy loss: is there any significant difference?

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