Elevated F-EDN correlates with mucosal eosinophil degranulation in patients with IBS—A possible association with microbiota?

Abstract

We show, for the first time, a correlation between F-EDN levels and degranulation of eosinophils in the colon of IBS patients which might play a role in IBS pathophysiology.

Genetic analyses of treatment response in primary care IBS, a pilot study

“…Based on publicly available gene expression data, the SNP in SLC6A4 is associated with increased expression in the muscularis of the oesophagus; this is in line with the antispasmodic properties of OB although not in the anatomical region expected. Likewise, the association of a SNP in CCR3 with response to dietary treatment reinforces our hypothesis that (altered) eosinophil function plays a role in symptom generation in IBS and is in line with recent evidence suggesting a role for eosinophils in IBS and atypical allergy-like reactions to food in at least a subset of patients 6 7…”

“…Eosinophil and mast cell related genes ( CCR3, SIGLEC8 , MRGPRX2 , IL5RA , CCL11 and IL33 ) were explored in the diet arm based on the hypothesis that activation of these cell types contributed to food-induced symptom generation in IBS (table 1). 6–8…”

Advances in the treatment of inflammatory bowel disease: Focus on polysaccharide nanoparticulate drug delivery systems

“…181 In particular, inflamed colon contains high concentrations of transferrin and eosinophil cationic protein. [182][183][184][185] This property was exploited in designing negatively charged DDS that preferentially adhered inflamed tissue in vivo through electrostatic interactions with positively charged proteins. 159,186,187 However, conflicting results were obtained in the literature on the impact of nanoparticle charge on their accumulation in the inflamed colon since the net charge of mucus remains negative due to the presence of mucins.…”

Immune Activation in Functional Dyspepsia: Bystander Becoming the Suspect

“…Moreover, the inflammatory infiltrate in IBS predominantly consists of mast cells, initially reported in the terminal ileum ( Weston et al, 1993 ) and cecum ( O’Sullivan et al, 2000 ), but later also in other parts of the colon and even more proximally in the small intestine ( Bashashati et al, 2018 ; Robles et al, 2019 ). However, the increased infiltration and degranulation of eosinophils in the colonic mucosa also suggested a role for eosinophils in IBS ( Katinios et al, 2020 ; Salvo-Romero et al, 2020 ; Casado-Bedmar et al, 2021 ). To which extent this contributes to the frequent overlap between the two disorders is not yet understood.…”